Production Method 1

767-12-4

932-01-4

1193-46-0

Reaction Conditions

1.1 Reagents: Peracetic acid Catalysts: stereoisomer of Bis(1,1,1-trifluoromethanesulfonato-κO)[rel-(3R,9R)-3,6,9-trimet… Solvents: Acetonitrile ;  -35 °C
1.2 -35 °C

Reference

Trapping a Highly Reactive Nonheme Iron Intermediate That Oxygenates Strong C-H Bonds with Stereoretention

Serrano-Plana, Joan; Oloo, Williamson N.; Acosta-Rueda, Laura; Meier, Katlyn K.; Verdejo, Begona; et al, Journal of the American Chemical Society, 2015, 137(50), 15833-15842

Production Method 2

767-12-4

932-01-4

4255-62-3

1193-47-1

2979-19-3

1193-46-0

Reaction Conditions

1.1 Reagents: Ceric ammonium nitrate Catalysts: (OC-6-43)-[Octahydro-1,4-dimethyl-7-[(2-pyridinyl-κN)methyl]-1H-1,4,7-triazonine… Solvents: Acetonitrile ,  Water ;  30 min, 0 °C; 30 min, 0 °C
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  0 °C

Reference

Iron-Catalyzed C-H Hydroxylation and Olefin cis-Dihydroxylation Using a Single-Electron Oxidant and Water as the Oxygen-Atom Source

Garcia-Bosch, Isaac; Codola, Zoel; Prat, Irene; Ribas, Xavi; Lloret-Fillol, Julio; et al, Chemistry - A European Journal, 2012, 18(42), 13269-13273

Cyclohexanol,3,3-dimethyl- Preparation Products

• 4,4-dimethylcyclohexan-1-ol (932-01-4)
• 4,4-dimethylcyclohexan-1-one (4255-62-3)
• 2,2-dimethylcyclohexan-1-one (1193-47-1)
• 3,3-dimethylcyclohexan-1-one (2979-19-3)
• Cyclohexanol,3,3-dimethyl- (767-12-4)
• 2,2-Dimethylcyclohexan-1-ol (1193-46-0)

• 1. Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
  Benjamin Gabriel Poulson,Kacper Szczepski,Joanna Izabela Lachowicz,Lukasz Jaremko,Abdul-Hamid Emwas,Mariusz Jaremko RSC Adv., 2020,10, 215-227
• 2. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 3. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
  M. Sheykhan,S. Khani,S. Shaabanzadeh,M. Joafshan Green Chem., 2017,19, 5940-5948
• 4. An amphoteric reactivity of a mixed-valent bis(μ-oxo)dimanganese(iii,iv) complex acting as an electrophile and a nucleophile?
  Muniyandi Sankaralingam,So Hyun Jeon,Yong-Min Lee,Mi Sook Seo,Wonwoo Nam Dalton Trans., 2016,45, 376-383
• 5. An approach to 7-aza-1-phosphanorbornane complexes: strain promoted rearrangement of 1-iminylphosphirane complexes and cycloaddition with olefins?
  Yang Xu,Min Wang,Donghui Wei,Rongqiang Tian,Zheng Duan,Fran?ois Mathey Dalton Trans., 2019,48, 5523-5526

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Secondary alcohols
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alcohols and polyols Secondary alcohols

Comprehensive Overview of Cyclohexanol,3,3-dimethyl- (CAS No. 767-12-4): Properties, Applications, and Industry Insights

Cyclohexanol,3,3-dimethyl- (CAS No. 767-12-4), also known as 3,3-dimethylcyclohexanol, is a versatile organic compound widely used in industrial and research applications. This saturated cyclic alcohol features a cyclohexane backbone substituted with a hydroxyl group and two methyl groups at the 3-position, imparting unique physicochemical properties. Its molecular formula C8H16O and moderate polarity make it valuable as an intermediate in flavor and fragrance synthesis, pharmaceutical excipients, and specialty solvent formulations.

Recent interest in sustainable chemicals has spotlighted 3,3-dimethylcyclohexanol due to its potential in green chemistry applications. Studies highlight its role as a precursor for bio-based polymers and low-VOC solvents, aligning with global trends toward eco-friendly manufacturing. Analytical techniques like GC-MS and HPLC confirm its high purity (>98%), while its boiling point (195-200°C) and water solubility (1.2 g/L at 25°C) facilitate diverse industrial processes.

In the flavor industry, this compound contributes to woody, camphoraceous notes in perfumes and food additives. Its structural similarity to menthol derivatives enables applications in cooling agents, with patents demonstrating enhanced stability compared to linear analogs. Researchers also explore its utility in non-phthalate plasticizers, addressing concerns about endocrine disruptors in PVC materials.

The synthesis of Cyclohexanol,3,3-dimethyl- typically involves hydrogenation of corresponding ketones or Grignard reactions. Process optimization studies focus on catalytic efficiency and waste reduction, with newer methods employing enzymatic catalysis for improved selectivity. Regulatory filings under REACH and TSCA confirm its compliant status for commercial use in major markets.

Emerging applications include electronic chemicals for semiconductor cleaning and lubricant additives where its thermal stability outperforms conventional options. Market analysts project 4.7% CAGR growth (2023-2030) for such high-performance intermediates, driven by demand in Asia-Pacific specialty chemical sectors. Proper storage in nitrogen-purged containers prevents oxidation, maintaining shelf life exceeding 24 months.

Frequently asked questions about CAS 767-12-4 include its isomeric purity (typically >90% trans-isomer), compatibility with epoxy resins, and biodegradability metrics (OECD 301B: 68% in 28 days). Comparative studies with cyclohexanol derivatives show superior hydrolytic stability, making it preferable for aqueous formulations. Recent patent activity (2021-2023) highlights innovations in continuous flow production and chiral resolution techniques.

Environmental profiling indicates low bioaccumulation potential (logPow 2.1) and moderate aquatic toxicity (EC50 Daphnia magna: 42 mg/L). These characteristics support its inclusion in GHS-compliant safety data sheets with standard PPE recommendations. Industry best practices emphasize closed-system handling to minimize workplace exposure, though its vapor pressure (0.12 mmHg at 25°C) presents negligible inhalation risk under normal conditions.

Cutting-edge research explores nanocatalyzed oxidation pathways to convert 3,3-dimethylcyclohexanol into value-added dicarboxylic acids for polyamide production. Synergistic effects with ionic liquids demonstrate enhanced reaction kinetics in peer-reviewed studies. These advancements position CAS 767-12-4 as a focal point for circular economy initiatives in chemical manufacturing.

• 932-01-4(4,4-dimethylcyclohexan-1-ol)
• 80-04-6(4,4'-(Propane-2,2-diyl)dicyclohexanol)
• 10534-31-3(Cyclohexanepropanol, a,g,g-trimethyl-4-(1-methylethyl)-)
• 70788-30-6(1-(2,2,6-TRIMETHYLCYCLOHEXYL)-3-HEXANOL)
• 21862-63-5(4-Tert-Butylcyclohexanol)
• 98-52-2(4-tert-butylcyclohexan-1-ol)
• 116-02-9(3,3,5-Trimethylcyclohexanol)
• 101896-23-5(Cyclohexanepropanol, a,g,g-trimethyl-4-(1-methylethyl)-, trans-)
• 10534-30-2(Cyclohexanepropanol,4-ethyl-a,g,g-trimethyl-)
• 20698-30-0(trans-4-tert-Pentylcyclohexanol)