Cas no 76639-94-6 (Florfenicol)

Florfenicol is a broad-spectrum bacteriostatic antibiotic belonging to the amphenicol class, structurally related to chloramphenicol but with enhanced efficacy and reduced toxicity. It exhibits potent activity against Gram-negative and Gram-positive bacteria, including strains resistant to other antimicrobials. Florfenicol functions by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. Its key advantages include high bioavailability, excellent tissue penetration, and stability against bacterial acetyltransferases, which often degrade similar compounds. Florfenicol is widely used in veterinary medicine for treating respiratory and enteric infections in livestock and aquaculture. Its low propensity for resistance development further underscores its utility in antimicrobial therapy.
Florfenicol structure
Florfenicol structure
Product Name:Florfenicol
CAS No:76639-94-6
MF:C12H14Cl2FNO4S
MW:358.213263988495
CID:90701
PubChem ID:114811
Update Time:2026-03-02

Florfenicol Chemical and Physical Properties

Names and Identifiers

    • Florfenicol
    • NUFLOR
    • [R-(R*,S*)]-2,2-DICHLORO-N-[1-(FLUOROMETHYL)-2-HYDROXY-2-[4-(METHYLSULFONYL)PHENYL]ETHYL]ACETAMIDE
    • SCH-25298
    • FLORFENICAL
    • FLEROXACINLACTATE
    • 2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]ethanamide
    • 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
    • Aquafen
    • 氟苯尼考原藥粉生產(chǎn)廠家行情價格
    • FLORFENICOL [EMA EPAR VETERINARY]
    • s4201
    • 2,2-Dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide
    • (-)-Florfenicol;SCH-25298
    • 2,2-Dichloro-N-((alpha S,beta-alpha R)-(fluoromethyl)-beta-hydroxy-4-methanesulfonylphenethyl)acetamide
    • NCGC00179366-01
    • FLORFENICOL [MI]
    • DTXCID7025500
    • FLORFENICOL COMPONENT OF ZELERIS
    • CHEBI:87185
    • Nuflor (TN)
    • FLORFENICOL INJECTION
    • thiamphenicol, 3-fluoro
    • DB11413
    • HMS2090I10
    • 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methanesulfonyl)phenyl)propan-2-yl)acetamide
    • Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-, methyl ester, (R-(R*,S*))-
    • FLORFENICOL [INN]
    • FLORFENICOL (EMA EPAR VETERINARY)
    • Tox21_110683
    • D-THREO-2,2-DICHLORO-N-(.ALPHA.-(FLUOROMETHYL)-.BETA.-HYDROXY-P-(METHYLSULFONYL)PHENETHYL)ACETAMIDE
    • 2,2-Dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide
    • 2,2-Dichlor-N-((1R,2S)-3-fluor-1-hydroxy- 1-(4-(methylsulfonyl)-phenyl)-propan-2-yl)-ethanamide
    • FLORFENICOL [MART.]
    • (-)-Florfenicol
    • (1R,2S)-2-DICHLOROACETAMIDO-3-FLUORO-1-[4-(METHYLSULFONYL) PHENYL]-1-PROPANOL
    • Z2065671685
    • FLORFENICOL COMPONENT OF OSURNIA
    • 2,2-Dichloro-N-((alphaS,betaR)-alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide
    • HMS2097P12
    • Loncor 300
    • Sch 25298
    • AB00513976
    • BSPBio_000950
    • Tox21_110683_1
    • chloramphen
    • HMS2230K18
    • (methylsulfonyl)phenyl)propan-2-yl)acetamide
    • BPBio1_001046
    • Florfenicol, analytical standard, for drug analysis
    • BRD-K11298197-001-03-9
    • 2,2-dichloro-N-[(1R,2R)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
    • Acetamide, 2,2-dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)-, (R-(R*,S*))-
    • florfenicolum
    • T72886
    • Nuflor Concentrate Solution
    • SPBio_003099
    • CCG-220955
    • CS-4857
    • FLORFENICOL [USAN]
    • Florvio 2.3% Concentrate Solution
    • 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
    • (1R,2S)-2-dichloroacetamido-3-fluoro-1-[4-(methylsulfonyl)phenyl]-1-propanol
    • A838774
    • EN300-7371088
    • MFCD00864834
    • 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-(4-methylsulfonylphenyl)ethyl]acetamide
    • 2,2-dichloro-N-{(1R,2S)-3-fluoro-1-hydroxy-1-[4-(methanesulfonyl)phenyl]propan-2-yl}acetamide
    • D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide
    • SCHEMBL21835523
    • Nuflor, Nuflor-S
    • AC-4340
    • FLORCON
    • SW197224-3
    • AB00513976_09
    • SCHEMBL49425
    • FLORFENICOL [JAN]
    • BF166386
    • HY-B1374
    • florphenicol
    • NCGC00016922-01
    • MLS002154071
    • NSC 759287
    • 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)-2-propyl]acetamide
    • Acetamide, 2,2-dichloro-N-((1S,2R)-1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)-
    • Prestwick2_000955
    • D-(-)-threo-2-Dichloroacetamido-3-fluoro-1-(4-methylsulfonylphenyl)-1-propanol
    • HMS3714P12
    • HMS1570P12
    • ZELERIS COMPONENT FLORFENICOL
    • 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-
    • Florfenicol (USAN/INN)
    • Prestwick3_000955
    • Prestwick1_000955
    • FLORFENICOL (MART.)
    • DTXSID9045500
    • AquaflorType A Medicated Article
    • KS-5028
    • 2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
    • Florfenicol [USAN:INN:BAN]
    • GTPL12923
    • UNII-9J97307Y1H
    • 2,2-dichloro-n-((1r,2s)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)-2-propyl)acetamide
    • C12H14Cl2FNO4S
    • NSC-759287
    • AKOS015889457
    • D04194
    • 73231-34-2
    • 3-fluorothiamphenicol
    • NuflorGOLD
    • Aquaflor Type A Medicated Article
    • CHEMBL1241590
    • F0811
    • Q408400
    • Norfenicol
    • OSURNIA COMPONENT FLORFENICOL
    • NCGC00179366-03
    • 9J97307Y1H
    • CAS-73231-34-2
    • SMR001233384
    • 76639-94-6
    • Prestwick0_000955
    • FLORFENICOL [GREEN BOOK]
    • AYIRNRDRBQJXIF-NXEZZACHSA-N
    • Nuflor-S
    • NCGC00179366-04
    • NS00009622
    • 2,2-DICHLORO-N-((.ALPHA.S,.BETA.R)-.ALPHA.-(FLUOROMETHYL)-.BETA.-HYDROXY-P-(METHYLSULFONYL)PHENETHYL)ACETAMIDE
    • Nuflor gold
    • BRD-K11298197-001-12-0
    • 1ST7005
    • Inchi： 1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
    • InChI Key： AYIRNRDRBQJXIF-NXEZZACHSA-N
    • SMILES： ClC(C(N[C@H](CF)[C@@H](C1C=CC(=CC=1)S(C)(=O)=O)O)=O)Cl

Computed Properties

  • Exact Mass: 357.00000
  • Monoisotopic Mass: 357
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 2
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 6
  • Complexity: 447
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: 0.8
  • Topological Polar Surface Area: 91.8A^2

Experimental Properties

  • Color/Form: No data avaiable
  • Density: 1.5±0.1 g/cm3
  • Melting Point: 153°C
  • Boiling Point: 617.5±55.0 °C at 760 mmHg
  • Flash Point: 327.3±31.5 °C
  • Refractive Index: 1.548
  • PSA: 91.85000
  • LogP: 2.85320
  • Vapor Pressure: 0.0±1.9 mmHg at 25°C

Florfenicol Security Information

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Florfenicol Spectrogram

1H NMR 300 MHz DMSO
1H NMR
13C NMR
13C NMR
LC-MS LC-ESI-QFT
LC-MS

Florfenicol Related Literature

Related Categories

Additional information on Florfenicol

Florfenicol: A Comprehensive Overview of its Chemical Profile and Therapeutic Applications

Florfenicol, a synthetic antibiotic belonging to the chloramphenicol group, is widely recognized for its potent bacteriostatic properties. The compound is characterized by the CAS number 76639-94-6, which serves as a unique identifier in the chemical and pharmaceutical industries. This introduction delves into the chemical structure, pharmacological mechanisms, therapeutic applications, and recent advancements in the research and development of Florfenicol.

The chemical structure of Florfenicol is a crucial determinant of its pharmacological activity. It is a chlorinated derivative of thiamphenicol, featuring a phenol ring substituted with a chlorine atom at the 3-position. This structural feature contributes to its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit. The molecular formula of Florfenicol is C??H??Cl?N?O?, reflecting its complex composition and the presence of multiple functional groups essential for its biological activity.

Florfenicol has been extensively studied for its efficacy against a broad spectrum of Gram-positive and Gram-negative bacteria. Its mechanism of action involves the inhibition of peptidyl transferase activity on the ribosome, thereby preventing the elongation step in protein synthesis. This process disrupts bacterial growth and proliferation, making Florfenicol particularly effective against respiratory tract infections, urinary tract infections, and certain systemic infections. The compound's high affinity for bacterial ribosomes while maintaining a lower toxicity profile in human cells has made it a valuable therapeutic option.

In recent years, research on Florfenicol has expanded to explore its potential applications beyond traditional antibiotic therapy. Studies have highlighted its role in combating multidrug-resistant bacterial strains, which pose significant challenges in clinical settings. The unique chemical properties of Florfenicol allow it to interact with bacterial ribosomes in a manner that is less susceptible to resistance mechanisms compared to other antibiotics. This has prompted investigations into combination therapies involving Florfenicol with other antimicrobial agents to enhance efficacy and reduce the risk of resistance development.

Moreover, Florfenicol has been investigated for its potential in treating certain inflammatory conditions associated with bacterial infections. Emerging research suggests that Florfenicol may exert anti-inflammatory effects by modulating immune responses. This dual action as both an antibiotic and an anti-inflammatory agent makes it a promising candidate for therapeutic strategies targeting chronic inflammatory diseases exacerbated by bacterial infections.

The pharmacokinetic profile of Florfenicol is another critical aspect influencing its clinical utility. The compound exhibits good oral bioavailability and can be administered via various routes, including intravenous and intramuscular injections. Its rapid absorption from the gastrointestinal tract allows for prompt therapeutic levels in the bloodstream. Additionally, Florfenicol has a relatively short half-life, necessitating frequent dosing schedules to maintain effective concentrations. These pharmacokinetic characteristics have been optimized through formulation advancements to improve patient compliance and therapeutic outcomes.

Recent clinical trials have demonstrated the efficacy of Florfenicol in treating severe respiratory infections caused by Gram-negative bacteria. These studies have shown that Florfenicol can be as effective as other modern antibiotics while maintaining a favorable safety profile. The results from these trials have reinforced the importance of Florfenicol in managing infections that are increasingly resistant to conventional treatments.

The development of novel formulations incorporating Florfenicol has also been a focus of recent research efforts. Nanotechnology-based delivery systems have been explored to enhance the bioavailability and targeted delivery of Florfenicol to infected sites. These advanced formulations aim to improve therapeutic efficacy while minimizing side effects associated with systemic administration.

In conclusion, Florfenicol remains a vital antibiotic with broad-spectrum activity against various bacterial pathogens. Its unique chemical structure and mechanism of action contribute to its effectiveness in treating diverse infections. Recent advancements in research highlight its potential beyond traditional antibiotic therapy, including roles in anti-inflammatory applications and combatting multidrug-resistant bacteria. As the landscape of infectious diseases continues to evolve, Florfenicol stands out as a reliable therapeutic option with ongoing opportunities for innovation and improvement.

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