Cas no 15318-45-3 (Thiamphenicol)

Thiamphenicol is a synthetic broad-spectrum antibiotic belonging to the amphenicol class. It exhibits bacteriostatic activity by inhibiting bacterial protein synthesis through binding to the 50S ribosomal subunit. Thiamphenicol is structurally similar to chloramphenicol but features a methylsulfonyl group in place of the nitro group, reducing the risk of aplastic anemia while retaining efficacy. It is effective against Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics. The compound demonstrates favorable pharmacokinetic properties, such as high oral bioavailability and tissue penetration, making it suitable for treating respiratory, urinary, and gastrointestinal infections. Its stability and reduced toxicity profile enhance its utility in veterinary and clinical applications.
Thiamphenicol structure
Thiamphenicol structure
Product Name:Thiamphenicol
CAS No:15318-45-3
MF:C12H15Cl2NO5S
MW:356.2222
MDL:MFCD00467983
CID:50083
PubChem ID:135726881
Update Time:2025-10-19

Thiamphenicol Chemical and Physical Properties

Names and Identifiers

    • thiamphenicol
    • methylsulfonyl chloramphenicol
    • D-THREO-2,2-DICHLORO-N-(BETA-HYDROXY-ALPHA-[HYDROXYMETHYL]-4-[METHYLSULFONYL]PHENETHYL)ACETAMIDE
    • D-THREO-2,2-DICHLORO-N-[BETA-HYDROXY-ALPHA-(HYDROXYMETHYL)-P-(METHYL-SULFONYL)PHENETHYL]ACETAMIDE
    • 8065c.b.
    • acetamide,2,2-dichloro-n-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl
    • dextrosulphenidol
    • thiocymetin
    • 2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-[4-(methylsulfonyl)phenyl]-2-propyl]acetamide
    • D-Thiocymetin
    • D-Thiophenicol
    • Neomyson
    • THIAMPHENICHOL
    • thiophenicol
    • win-5063-2
    • NSC 522822
    • Thiamcol
    • (+)-Thiamphenicol
    • Raceophenidol
    • Thiamphenicolum
    • Thiocymetin (TN)
    • Armai (TN)
    • Tiamfenicolo [DCIT]
    • Tiamfenicol [INN-Spanish]
    • Thiamphenicol (Thiophenicol)
    • Macphenicol
    • Masatirin
    • Efnicol
    • Rincrol
    • Urfamicina
    • Thiamphenicolum [INN-Latin]
    • Descocin
    • Urfamycine
    • Igralin
    • Hyrazin
    • Dexawin
    • SW 5063
    • Unaseran-D
    • Thiamphenicol [USAN:INN:BAN:JAN]
    • RACEPHENICOL
    • NCGC00178319-03
    • cid_27200
    • THIAMPHENICOL [MART.]
    • s2583
    • Thiamphenicol (JAN/USAN/INN)
    • SMR000857096
    • THIAMPHENICOL [WHO-DD]
    • Racephenicol [USAN]
    • Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, (R-(R*,R*))-
    • (+/-)-Thiamphenicol
    • CCRIS 8588
    • HY-B0479
    • THIAMPHENICOL [EP MONOGRAPH]
    • SW197006-3
    • BRD-K79711234-001-06-8
    • WIN 5063-2
    • Spectrum4_000733
    • D01407
    • D-threo-(1R,2R)-1-(p-Methylsulfonylphenyl)-2-dichloroacetamido-1,3-propanediol
    • EINECS 239-355-3
    • NS00098623
    • CHEMBL1236282
    • KBio2_004476
    • NCGC00178319-01
    • NSC-758396
    • Acetamide, 2,2-dichloro-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, rel-
    • SR-05000001829-1
    • GTPL12400
    • Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)-, D-threo-(+)
    • Acetamide, 2,2-dichloro-N-((1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-
    • HMS1568E11
    • Prestwick2_000025
    • Armai
    • Q425015
    • NSC-522822
    • HMS2095E11
    • dl-threo-2-Dichloroacetamido-1-(4-methylsulfonyl-phenyl)-1,3-propanediol
    • NCGC00178319-07
    • THIAMPHENICOL DL-FORM [MI]
    • Pharmakon1600-01503136
    • SPBio_002010
    • HMS2092L18
    • HMS2232E21
    • Acetamide, 2,2-dichloro-N-(2-hydroxy-1-(hydroxymethyl)-2-(4-(methylsulfonyl)phenyl)ethyl)-, (R*,R*)-(+-)-
    • BRD-K79711234-001-18-3
    • AB00052321_10
    • Racefenicol [INN]
    • MFCD00467983
    • D-d-threo-2-Dichloroacetamido-1-(4-methylsulfonylphenyl)-1,3-propanediol
    • UNII-283383NO13
    • BCP32746
    • BDBM58925
    • Thiamphenicol, analytical standard
    • NINDS_000842
    • Spectrum2_000856
    • MLS002154177
    • SPBio_000871
    • Racefenicolo [DCIT]
    • Spectrum3_001562
    • KBioGR_001026
    • BPBio1_000099
    • Racefenicolum [INN-Latin]
    • DivK1c_000842
    • ACETAMIDE, 2,2-DICHLORO-N-(.BETA.-HYDROXY-.ALPHA.-(HYDROXYMETHYL)-P-(METHYLSULFONYL)PHENETHYL)-, THREO-(+/-)-
    • 8065 C.B.
    • 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
    • D-(+)-threo-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)acetamide
    • DB08621
    • Acetamide,2,2-dichloro-N-[(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl]-
    • 2,2-bis(chloranyl)-N-[(1R,2R)-1-(4-methylsulfonylphenyl)-1,3-bis(oxidanyl)propan-2-yl]ethanamide
    • 1ST7002
    • CHEBI:32215
    • SR-05000001829
    • Spectrum_001428
    • Prestwick3_000025
    • Tox21_110577
    • Thiamphenicol dl-form
    • Racefenicolum
    • Prestwick1_000025
    • 2,2-DICHLORO-N-((1R,2R)-2-HYDROXY-1-(HYDROXYMETHYL)-2-(4-(METHYLSULFONYL)PHENYL)ETHYL)ACETAMIDE
    • THIAMPHENICOL [JAN]
    • AS-12501
    • NCGC00016714-01
    • WIN-5063
    • SCHEMBL34635
    • 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
    • Thiamphenicol 1000 microg/mL in Acetonitrile
    • Tox21_110577_1
    • Acetamide, 2,2-dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)-, threo-(+-)-
    • HMS1922G19
    • Thiophenicol;Dextrosulphenidol
    • IDI1_000842
    • AKOS015951269
    • MLS001332639
    • BSPBio_000089
    • KBio3_002564
    • SR-05000001829-3
    • NCGC00178319-06
    • Thiophenicol; Dextrosulphenidol; Descocin; Hyrazin; Masatirin; Urfamycine
    • DTXSID5021338
    • THIAMPHENICOL [INN]
    • AB00052321_11
    • SPECTRUM1503136
    • FLQ7571NPM
    • CAS-15318-45-3
    • Tox21_200816
    • KBio2_007044
    • NSC758396
    • TH8
    • 847-25-6
    • Prestwick_885
    • Prestwick0_000025
    • BRD-K79711234-001-17-5
    • ACETAMIDE, 2,2-DICHLORO-N-(2-HYDROXY-1-(HYDROXYMETHYL)-2-(4-(METHYLSULFONYL)PHENYL)ETHYL)-, (R*,R*)-(+/-)-
    • KBioSS_001908
    • KBio1_000842
    • BSPBio_003064
    • Spectrum5_001617
    • NCGC00258370-01
    • MLS001332640
    • SMP2_000125
    • T2802
    • CCG-40309
    • (+-)-threo-2,2-Dichloro-N-(beta-hydroxy-alpha-(hydroxymethyl)-p-(methylsulfonyl)phenethyl)acetamide
    • Thiamphenicol DL-
    • 2,2-dichloro-N-[(1R,2R)-2-hydroxy-2-(4-mesylphenyl)-1-methylol-ethyl]acetamide
    • 2,2-dichloro-N-{(1R,2R)-2-hydroxy-1-(hydroxymethyl)-2-[4-(methylsulfonyl)phenyl]ethyl}acetamide
    • HMS3712E11
    • NCGC00178319-02
    • Thiamphenicol, European Pharmacopoeia (EP) Reference Standard
    • BRD-K79711234-001-11-8
    • 283383NO13
    • SBI-0051779.P002
    • HMS502K04
    • THIAMPHENICOL [MI]
    • 2,2-dichloro-N-((1R,2R)-1,3-dihydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide
    • DTXCID801338
    • KBio2_001908
    • UNII-FLQ7571NPM
    • Tiamfenicolo
    • 15318-45-3
    • Racefenicolo
    • Tiamfenicol
    • THIAMPHENICOL [USAN]
    • Thiamphenicol
    • MDL： MFCD00467983
    • Inchi： 1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
    • InChI Key： OTVAEFIXJLOWRX-NXEZZACHSA-N
    • SMILES： ClC([H])(C(N([H])[C@]([H])(C([H])([H])O[H])[C@@]([H])(C1C([H])=C([H])C(=C([H])C=1[H])S(C([H])([H])[H])(=O)=O)O[H])=O)Cl

Computed Properties

  • Exact Mass: 355.00500
  • Monoisotopic Mass: 355.0047991 g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 21
  • Rotatable Bond Count: 6
  • Complexity: 443
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 2
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: 2
  • XLogP3: -0.3
  • Topological Polar Surface Area: 112
  • Molecular Weight: 356.2

Experimental Properties

  • Color/Form: Powder
  • Density: 1.3281 (rough estimate)
  • Melting Point: 164.0 to 168.0 deg-C
  • Boiling Point: 695.9±55.0 °C at 760 mmHg
  • Flash Point: 374.7±31.5 °C
  • Refractive Index: 1.6000 (estimate)
  • Solubility: ethanol: 50?mg/mL, clear, colorless
  • Water Partition Coefficient: Soluble in acetonitrile or DMF. Slightly soluble in water
  • PSA: 112.08000
  • LogP: 1.87600
  • Solubility: Not determined
  • Merck: 9301
  • Specific Rotation: D25 +12.9° (ethanol)

Thiamphenicol Security Information

  • Signal Word：Warning
  • Hazard Statement： H302
  • Warning Statement： P280-P305+P351+P338
  • WGK Germany：2
  • Safety Instruction： S22; S24/25
  • Regulatory Condition Code：Class Q (sugars, alkaloids, antibiotics, hormones)
  • RTECS：AB6680000
  • Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month

Thiamphenicol Customs Data

  • HS CODE：2941400000
  • Customs Data：

    China Customs Code:

    2924299090

    Overview:

    2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to, packing

    Summary:

    2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Thiamphenicol Pricemore >>

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Thiamphenicol Suppliers

Amadis Chemical Company Limited
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(CAS:15318-45-3)Thiamphenicol
Order Number:A809401
Stock Status:in Stock
Quantity:25g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 04:50
Price ($):386.0
Zhengzhou Baoyu Pharmaceutical Co., Ltd.
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(CAS:15318-45-3)Thiamphenicol
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Purity:99% HPLC
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Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:15318-45-3)甲砜霉素
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Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 13:01
Price ($):discuss personally
Suzhou Senfeida Chemical Co., Ltd
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(CAS:15318-45-3)Thiamphenicol
Order Number:sfd022
Stock Status:in Stock
Quantity:200kg
Purity:99.9%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
Price ($):discuss personally

Thiamphenicol Spectrogram

13C NMR
13C NMR
1H NMR 300 MHz DMSO
1H NMR

Thiamphenicol Related Literature

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Amadis Chemical Company Limited
(CAS:15318-45-3)Thiamphenicol
A809401
Purity:99%
Quantity:25g
Price ($):386.0
Email
Zhengzhou Baoyu Pharmaceutical Co., Ltd.
(CAS:15318-45-3)Thiamphenicol
LE073
Purity:99% HPLC
Quantity:5KG/1KG/25KG/100KG
Price ($):Inquiry
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