Cas no 73231-34-2 (Florfenicol)
Florfenicol Chemical and Physical Properties
Names and Identifiers
-
- Florfeniol
- Flofenicol
- 2,2-dichloro-N-{(1R,2S)-3-fluoro-1-hydroxy-1-[4-(methylsulfonyl)phenyl]propan-2-yl}acetamide
- FLORFENICOL
- 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
- FLUPROFEN
- (-)-Florfenicol
- 2,2-DIBROMODECAFLUOROPENTANE
- 2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methanesulfonyl)phenyl]ethyl]acetamide
- AQUAFEN
- Aquaflor
- Fluorothiamphenicol
- NUFLOR
- SCH-25298
- D-(-)-threo-2-Dichloroacetamido-3-fluoro-1-(4-methylsulfonylphenyl)-1-propanol
- 2,2-Dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)-2-propyl]acetamide
- [R-(R*, R*)]-N-[1-(Fluoromethyl)-2-hydroxy-2-(4-(methylsulforyl)phenyl)-ethyl]-2,2-dichloroacetamide
- Nuflor gold
- Sch 25298
- florphenicol
- C12H14Cl2FNO4S
- Florfenicol [USAN:INN:BAN]
- 9J97307Y1H
- D-threo-2,2-Dichloro-N-(alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide
- 2,2-Dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)acetamide
- DSSTox_RID_80918
- DSSTo
- FLORFENICOL [EMA EPAR VETERINARY]
- s4201
- 2,2-Dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methylsulfonyl)phenyl)propan-2-yl)acetamide
- (-)-Florfenicol;SCH-25298
- 2,2-Dichloro-N-((alpha S,beta-alpha R)-(fluoromethyl)-beta-hydroxy-4-methanesulfonylphenethyl)acetamide
- [R-(R*,S*)]-2,2-Dichloro-N-[1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
- NCGC00179366-01
- FLORFENICOL [MI]
- DTXCID7025500
- FLORFENICOL COMPONENT OF ZELERIS
- CHEBI:87185
- Nuflor (TN)
- FLORFENICOL INJECTION
- thiamphenicol, 3-fluoro
- DB11413
- HMS2090I10
- 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-(methanesulfonyl)phenyl)propan-2-yl)acetamide
- Benzenesulfonic acid, 4-(2-((dichloroacetyl)amino)-3-fluoro-1-hydroxypropyl)-, methyl ester, (R-(R*,S*))-
- FLORFENICOL [INN]
- FLORFENICOL (EMA EPAR VETERINARY)
- Tox21_110683
- D-THREO-2,2-DICHLORO-N-(.ALPHA.-(FLUOROMETHYL)-.BETA.-HYDROXY-P-(METHYLSULFONYL)PHENETHYL)ACETAMIDE
- 2,2-Dichlor-N-((1R,2S)-3-fluor-1-hydroxy- 1-(4-(methylsulfonyl)-phenyl)-propan-2-yl)-ethanamide
- FLORFENICOL [MART.]
- (1R,2S)-2-DICHLOROACETAMIDO-3-FLUORO-1-[4-(METHYLSULFONYL) PHENYL]-1-PROPANOL
- Z2065671685
- FLORFENICOL COMPONENT OF OSURNIA
- 2,2-Dichloro-N-((alphaS,betaR)-alpha-(fluoromethyl)-beta-hydroxy-p-(methylsulfonyl)phenethyl)acetamide
- HMS2097P12
- Loncor 300
- AB00513976
- BSPBio_000950
- Tox21_110683_1
- chloramphen
- HMS2230K18
- (methylsulfonyl)phenyl)propan-2-yl)acetamide
- BPBio1_001046
- Florfenicol, analytical standard, for drug analysis
- BRD-K11298197-001-03-9
- 2,2-dichloro-N-[(1R,2R)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
- Acetamide, 2,2-dichloro-N-(1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)-, (R-(R*,S*))-
- florfenicolum
- T72886
- Nuflor Concentrate Solution
- SPBio_003099
- CCG-220955
- CS-4857
- FLORFENICOL [USAN]
- Florvio 2.3% Concentrate Solution
- 2,2-Dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl]ethyl]acetamide
- (1R,2S)-2-dichloroacetamido-3-fluoro-1-[4-(methylsulfonyl)phenyl]-1-propanol
- A838774
- EN300-7371088
- MFCD00864834
- 2,2-dichloro-N-[(1S,2R)-1-(fluoromethyl)-2-hydroxy-2-(4-methylsulfonylphenyl)ethyl]acetamide
- 2,2-dichloro-N-{(1R,2S)-3-fluoro-1-hydroxy-1-[4-(methanesulfonyl)phenyl]propan-2-yl}acetamide
- SCHEMBL21835523
- Nuflor, Nuflor-S
- AC-4340
- FLORCON
- SW197224-3
- AB00513976_09
- SCHEMBL49425
- FLORFENICOL [JAN]
- BF166386
- HY-B1374
- NCGC00016922-01
- MLS002154071
- NSC 759287
- Acetamide, 2,2-dichloro-N-((1S,2R)-1-(fluoromethyl)-2-hydroxy-2-(4-(methylsulfonyl)phenyl)ethyl)-
- Prestwick2_000955
- HMS3714P12
- HMS1570P12
- ZELERIS COMPONENT FLORFENICOL
- 2,2-dichloro-N-((1R,2S)-3-fluoro-1-hydroxy-1-(4-
- Florfenicol (USAN/INN)
- Prestwick3_000955
- Prestwick1_000955
- FLORFENICOL (MART.)
- DTXSID9045500
- AquaflorType A Medicated Article
- KS-5028
- 2,2-dichloro-N-[(1R,2S)-3-fluoro-1-hydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
- GTPL12923
- UNII-9J97307Y1H
- 2,2-dichloro-n-((1r,2s)-3-fluoro-1-hydroxy-1-(4-methylsulfonylphenyl)-2-propyl)acetamide
- NSC-759287
- AKOS015889457
- D04194
- 73231-34-2
- 3-fluorothiamphenicol
- NuflorGOLD
- Aquaflor Type A Medicated Article
- CHEMBL1241590
- F0811
- Q408400
- Norfenicol
- OSURNIA COMPONENT FLORFENICOL
- NCGC00179366-03
- CAS-73231-34-2
- SMR001233384
- 76639-94-6
- Prestwick0_000955
- FLORFENICOL [GREEN BOOK]
- AYIRNRDRBQJXIF-NXEZZACHSA-N
- Nuflor-S
- NCGC00179366-04
- NS00009622
- 2,2-DICHLORO-N-((.ALPHA.S,.BETA.R)-.ALPHA.-(FLUOROMETHYL)-.BETA.-HYDROXY-P-(METHYLSULFONYL)PHENETHYL)ACETAMIDE
- BRD-K11298197-001-12-0
- 1ST7005
- Florfenicol
-
- MDL： MFCD00864834
- Inchi： 1S/C12H14Cl2FNO4S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-15)16-12(18)11(13)14/h2-5,9-11,17H,6H2,1H3,(H,16,18)/t9-,10-/m1/s1
- InChI Key： AYIRNRDRBQJXIF-NXEZZACHSA-N
- SMILES： ClC(C(N[C@H](CF)[C@@H](C1C=CC(=CC=1)S(C)(=O)=O)O)=O)Cl
- BRN： 4202553
Computed Properties
- Exact Mass: 357.00000
- Monoisotopic Mass: 357
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 2
- Hydrogen Bond Acceptor Count: 5
- Heavy Atom Count: 21
- Rotatable Bond Count: 6
- Complexity: 447
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 2
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Functional 3D Acceptor Count: 4
- isomeric RMSD: 0.8
- CID conformational isomer Count: 46
- Surface Charge: 0
- Functional 3D Donor Count: 2
- Functional 3D ring Count: 1
- Rotatable Bond Count: 7
- Tautomer Count: 2
- XLogP3: 0.8
- Topological Polar Surface Area: 91.8
Experimental Properties
- Color/Form: White or off white solid
- Density: 1.5±0.1 g/cm3
- Melting Point: 153.0 to 157.0 deg-C
- Boiling Point: 618℃
- Flash Point: >110°(230°F)
- Refractive Index: 1.548
- Solubility: Soluble in ethanol to 25mM and in DMSO to 100mM
- PSA: 91.85000
- LogP: 2.85320
- Merck: 4109
- Specific Rotation: -16° to -19° (c=1, DMF)
- Solubility: Dissolve in methanol, slightly dissolve in glacial acetic acid, and slightly dissolve in water or chloroform
Florfenicol Security Information
- Signal Word：Warning
- Hazard Statement： H315; H319; H335
- Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
- WGK Germany：3
- Hazard Category Code： 36/37/38
- Safety Instruction： S26-S36
- RTECS：DB6034000
-
Hazardous Material Identification：
- Storage Condition：Powder -20°C 3 years ? 4°C 2 years In solvent -80°C 6 months ? -20°C 1 month
- Risk Phrases：R36/37/38
Florfenicol Customs Data
- Customs Data：
China Customs Code:
2930909090Overview:
2930909090. Other organic sulfur compounds. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
Florfenicol Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd. | F0811-5G |
Florfenicol |
73231-34-2 | >98.0%(HPLC)(N) | 5g |
￥690.00 | 2024-04-16 | |
| TRC | F405750-50mg |
Florfenicol |
73231-34-2 | 50mg |
$ 55.00 | 2022-01-08 | ||
| TRC | F405750-500mg |
Florfenicol |
73231-34-2 | 500mg |
$ 52.00 | 2023-09-07 | ||
| TRC | F405750-1g |
Florfenicol |
73231-34-2 | 1g |
$ 63.00 | 2023-09-07 | ||
| TRC | F405750-10g |
Florfenicol |
73231-34-2 | 10g |
$ 120.00 | 2022-01-08 | ||
| abcr | AB426360-5 g |
2,2-Dichlor-N-((1R,2S)-3-fluor-1-hydroxy- 1-(4-(methylsulfonyl)-phenyl)-propan-2-yl)-ethanamide, 95%; . |
73231-34-2 | 95% | 5g |
€65.10 | 2023-07-18 | |
| abcr | AB426360-25 g |
2,2-Dichlor-N-((1R,2S)-3-fluor-1-hydroxy- 1-(4-(methylsulfonyl)-phenyl)-propan-2-yl)-ethanamide, 95%; . |
73231-34-2 | 95% | 25 g |
€112.00 | 2023-07-18 | |
| abcr | AB426360-100 g |
2,2-Dichlor-N-((1R,2S)-3-fluor-1-hydroxy- 1-(4-(methylsulfonyl)-phenyl)-propan-2-yl)-ethanamide, 95%; . |
73231-34-2 | 95% | 100 g |
€244.90 | 2023-07-18 | |
| abcr | AB426360-500 g |
2,2-Dichlor-N-((1R,2S)-3-fluor-1-hydroxy- 1-(4-(methylsulfonyl)-phenyl)-propan-2-yl)-ethanamide, 95%; . |
73231-34-2 | 95% | 500g |
€572.00 | 2021-09-16 | |
| WU HAN AN JIE KAI Biomedical Technology Co., Ltd. | ajci11798-50mg |
Florfenicol |
73231-34-2 | 98% | 50mg |
￥604.00 | 2023-09-09 |
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Florfenicol Related Literature
-
Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
-
Dhamodaran Manikandan,S. Amirthapandian,I. S. Zhidkov,A. I. Kukharenko,S. O. Cholakh,Ramaswamy Murugan Phys. Chem. Chem. Phys., 2018,20, 6500-6514
-
Bo Cao,Yin Wei Chem. Commun., 2018,54, 2870-2873
-
Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
-
Kaiyuan Huang,Wangkang Qiu,Meilian Ou,Xiaorui Liu,Zenan Liao,Sheng Chu RSC Adv., 2020,10, 18824-18829
Related Categories
- Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzenesulfonyl compounds
- Pesticide Chemicals Pesticide Active Ingredients Standard Substances
- Pharmaceutical and Biochemical Products Pharmaceutical Active Ingredients Standard Substances
- Other Chemical Reagents
Additional information on Florfenicol
Florfenicol: A Comprehensive Overview of its Chemical Profile, Applications, and Recent Research Developments
Florfenicol, a synthetic antibiotic belonging to the chloramphenicol class, is widely recognized for its significant role in the treatment of bacterial infections. With a CAS number of 73231-34-2, this compound has been extensively studied for its efficacy and mechanism of action. The chemical structure of Florfenicol consists of a chlorinated phenol ring linked to an isopropyl chain, which contributes to its potent antibacterial properties. This introduction aims to provide a detailed exploration of Florfenicol, including its chemical properties, therapeutic applications, and the latest advancements in research.
The chemical name of Florfenicol is (2R,3S,4S)-1-chloro-2-(D-ribofuranosyl)-1,3-dihydroxy-4-(isopropylidene)cyclohexa-2,5-dienone. This intricate structure underscores the complexity and specificity of its interaction with bacterial ribosomes. Florfenicol functions by inhibiting protein synthesis in bacteria, thereby preventing the elongation process at the ribosomal level. This mechanism makes it particularly effective against a broad spectrum of Gram-positive and Gram-negative bacteria.
In recent years, Florfenicol has gained attention for its potential applications in veterinary medicine. Its efficacy against respiratory tract infections in animals has made it a preferred choice for treating conditions such as pneumonia and bronchitis. Furthermore, studies have explored its use in aquaculture to combat bacterial infections in fish and shellfish. The compound's stability under various environmental conditions enhances its suitability for these applications.
One of the most compelling aspects of Florfenicol is its versatility in research settings. Researchers have been investigating its potential as a lead compound for developing novel antibiotics due to its unique chemical scaffold. Recent studies have highlighted the structural modifications that can enhance its antibacterial activity while minimizing side effects. For instance, modifications to the chloramphenicol moiety have shown promising results in reducing toxicity without compromising efficacy.
The pharmacokinetic properties of Florfenicol have also been extensively studied. Its oral bioavailability is relatively high, making it suitable for oral administration in both humans and animals. Additionally, its distribution across various body tissues allows for targeted treatment of infections. However, concerns regarding potential side effects, such as bone marrow suppression, have led to careful monitoring and dosage adjustments in clinical settings.
Advances in computational chemistry have furthered the understanding of Florfenicol's interactions with bacterial ribosomes. Molecular dynamics simulations have provided insights into how changes in the chemical structure can modulate binding affinity and resistance profiles. These findings are crucial for designing next-generation antibiotics that are more effective and less prone to resistance development.
The environmental impact of Florfenicol has also been a subject of interest. Studies have examined its persistence in aquatic ecosystems and potential effects on non-target organisms. Efforts to develop environmentally friendly formulations and disposal methods are ongoing to mitigate any adverse ecological consequences.
Future research directions for Florfenicol include exploring its role in combination therapies. By pairing it with other antibiotics or antiviral agents, researchers aim to develop synergistic treatments that can overcome resistance mechanisms more effectively. Additionally, investigating its potential use in treating multidrug-resistant infections is a priority given the growing global health challenge posed by such pathogens.
In conclusion, Florfenicol remains a vital compound in the field of antibiotics due to its broad-spectrum activity and versatility. The latest research developments continue to uncover new possibilities for its application and improvement. As scientists delve deeper into understanding its mechanisms and interactions, Florfenicol is poised to play an even greater role in addressing bacterial infections worldwide.
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