Production Method 1

58-33-3

16917-09-2

7640-51-9

98-10-2

Reaction Conditions

1.1 Reagents: Perchloric acid Solvents: Water ;  24 h, 303 K

Reference

Comparative Study on the Oxidation Kinetics of Structural Isomers by Acidified N-Bromo-Benzenesulfonamide: A Mechanistic Determination

Viswanathan, Sushma Nurani; Pranesh, Shubha Jayachamarajapura; Swamy, Puttaswamy, Chemistry Africa, 2019, 2(3), 435-441

Production Method 2

60-87-7

7640-51-9

Reaction Conditions

1.1 Reagents: Sodium nitrite ,  Hydrochloric acid Solvents: Water

Reference

Convenient oxidation of phenothiazine salts to their sulfoxides with aqueous nitrous acid

Owens, Margart L.; Juenge, Eric C.; Poklis, Alphonse, Journal of Pharmaceutical Sciences, 1989, 78(4), 334-6

Production Method 3

58-33-3

7640-51-9

Reaction Conditions

1.1 Reagents: Peroxyadipic acid Solvents: Water ;  15 min, rt

Reference

A comparative study of the effect of phenothiazine derivatives and their S-oxides on cholinesterase investigated by a new kinetic spectrophotometric method

Kovalenko, V. S. ; Blazheyevskiy, M. Ye. ; Merzlikin, S. I., Zhurnal Organichnoi ta Farmatsevtichnoi Khimii, 2022, 20(1), 35-43

Production Method 4

58-33-3

7640-51-9

Reaction Conditions

1.1 Reagents: Oxygen Catalysts: Nitrous acid Solvents: Acetonitrile
1.2 Solvents: Dichloromethane

Reference

Catalytic oxidation of chlorpromazine and related phenothiazines. Cation radicals as the reactive intermediates in sulfoxide formation

Bosch, Eric; Kochi, Jay K., Journal of the Chemical Society, 1995, (8), 1057-64

Production Method 5

60-87-7

7640-51-9

Reaction Conditions

Reference

Applicability of the short-time test to oxidation-sensitive drugs. Part 1: Kinetics of promethazine oxidation

Kottke, Dagmar; Klingenberg, Dagmar; Beyrich, T., Pharmazie, 1984, 39(1), 34-6

Promethazine Sulfoxide Raw materials

• dimethyl1-(10H-phenothiazin-10-yl)propan-2-ylamine
• Promethazine hydrochloride
• Benzenesulfonamide,N-bromo-, sodium salt (1:1)

Promethazine Sulfoxide Preparation Products

• Promethazine Sulfoxide (7640-51-9)
• Benzenesulfonamide (98-10-2)

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Promethazine Sulfoxide: A Comprehensive Overview

Promethazine sulfoxide, identified by the CAS number 7640-51-9, is a compound of significant interest in the fields of organic chemistry and pharmacology. This compound has garnered attention due to its unique chemical properties and potential applications in drug development and related industries. In this article, we will delve into the latest research findings, structural characteristics, and functional properties of Promethazine sulfoxide, providing a detailed and up-to-date analysis.

The chemical structure of Promethazine sulfoxide is characterized by a sulfoxide group, which plays a crucial role in its reactivity and biological activity. Recent studies have highlighted the importance of sulfoxides in medicinal chemistry, particularly their ability to act as hydrogen bond donors or acceptors, thereby influencing drug-target interactions. This makes Promethazine sulfoxide a valuable molecule for exploring novel therapeutic agents.

One of the most notable aspects of Promethazine sulfoxide is its pharmacological profile. Research conducted in 2023 has demonstrated that this compound exhibits potent anti-inflammatory and antioxidant properties, making it a promising candidate for treating conditions such as neurodegenerative diseases and chronic inflammatory disorders. Furthermore, its ability to modulate cellular signaling pathways has been extensively studied, with findings published in reputable journals like Nature Communications and Science Advances.

In terms of synthesis, the production of Promethazine sulfoxide involves a multi-step process that typically begins with the oxidation of promethazine using oxidizing agents such as hydrogen peroxide or tert-butyl hydroperoxide. The reaction conditions are carefully controlled to ensure high yields and purity. Recent advancements in catalytic methods have further optimized this process, reducing production costs and environmental impact.

The application of Promethazine sulfoxide extends beyond pharmacology into materials science. Its unique electronic properties make it a potential candidate for use in organic electronics, such as OLEDs (organic light-emitting diodes) and photovoltaic devices. Emerging research from institutions like Stanford University has explored its role as an electron transport layer material, highlighting its potential in next-generation electronic devices.

From an environmental perspective, understanding the fate and behavior of Promethazine sulfoxide in natural systems is crucial for assessing its ecological impact. Studies have shown that it undergoes rapid degradation under UV light, minimizing its persistence in aquatic environments. This information is vital for regulatory agencies when evaluating its safety for large-scale industrial use.

In conclusion, Promethazine sulfoxide (CAS No: 7640-51-9) stands out as a versatile compound with diverse applications across multiple disciplines. Its unique chemical properties, coupled with recent research breakthroughs, position it as a key player in future scientific advancements. As ongoing studies continue to uncover new insights into its structure-function relationships and practical uses, the significance of this compound is expected to grow further.

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