• 1. Embedding heteroatoms: an effective approach to create porphyrin-based functional materials
  Norihito Fukui,Keisuke Fujimoto,Hideki Yorimitsu,Atsuhiro Osuka Dalton Trans., 2017,46, 13322-13341
• 2. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064
• 3. EWOD-driven droplet microfluidic device integrated with optoelectronic tweezers as an automated platform for cellular isolation and analysis?
  Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
• 4. Enantiomeric helical TiO2 nanofibers modulate different peptide assemblies and subsequent cellular behaviors?
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• 5. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
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• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Halobenzoic acids and derivatives

5-Iodo-2,4-dimethylbenzoic Acid (CAS No. 742081-03-4): Properties, Applications, and Market Insights

5-Iodo-2,4-dimethylbenzoic acid (CAS No. 742081-03-4) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research. This iodinated benzoic acid derivative is characterized by its unique molecular structure, which combines a carboxylic acid functional group with iodine and methyl substituents. The presence of these functional groups makes 5-Iodo-2,4-dimethylbenzoic acid a versatile intermediate in synthetic chemistry, particularly in the development of active pharmaceutical ingredients (APIs) and fine chemicals.

The compound's molecular formula is C₉H₉IO₂, with a molecular weight of 276.07 g/mol. Its iodo-substituted aromatic ring provides distinct reactivity patterns that are valuable in cross-coupling reactions, such as Suzuki-Miyaura and Heck reactions, which are widely used in drug discovery. Researchers often search for "5-Iodo-2,4-dimethylbenzoic acid synthesis" or "CAS 742081-03-4 applications" to explore its potential in their projects. The compound's crystalline form and moderate solubility in organic solvents like ethanol and dimethyl sulfoxide (DMSO) make it suitable for various laboratory applications.

One of the trending topics in chemical research is the development of iodinated compounds for medicinal chemistry. 5-Iodo-2,4-dimethylbenzoic acid is frequently investigated as a building block for drug candidates targeting inflammation and metabolic disorders. Its structural features allow for further functionalization, enabling the creation of novel analogs with potential therapeutic effects. Recent studies have explored its role in designing inhibitors for enzymes like cyclooxygenase (COX), which are relevant in pain management research.

In the pharmaceutical industry, 5-Iodo-2,4-dimethylbenzoic acid is valued for its role in high-value intermediate synthesis. Companies specializing in custom synthesis often list this compound in their catalogs to meet the growing demand from drug development teams. The global market for such intermediates is expanding, driven by increased R&D investments in personalized medicine and targeted therapies. Searches for "buy 5-Iodo-2,4-dimethylbenzoic acid" or "742081-03-4 supplier" reflect this commercial interest.

From a safety perspective, 5-Iodo-2,4-dimethylbenzoic acid requires standard laboratory handling procedures. While not classified as highly hazardous, proper personal protective equipment (PPE) including gloves and safety goggles should be used when working with this compound. Its stability under normal conditions and compatibility with common laboratory practices contribute to its widespread use in academic and industrial settings.

The analytical characterization of 5-Iodo-2,4-dimethylbenzoic acid typically involves techniques such as nuclear magnetic resonance (NMR) spectroscopy, high-performance liquid chromatography (HPLC), and mass spectrometry. These methods confirm the compound's purity and identity, which are critical for research applications. Quality control specifications for CAS 742081-03-4 generally require ≥95% purity, with detailed certificates of analysis provided by reputable suppliers.

Looking ahead, the demand for iodinated aromatic compounds like 5-Iodo-2,4-dimethylbenzoic acid is expected to grow in parallel with advancements in radiopharmaceuticals and diagnostic imaging agents. The iodine atom in its structure offers potential for radioisotope labeling, making it interesting for positron emission tomography (PET) tracer development. This application aligns with current trends in precision medicine and non-invasive diagnostic technologies.

For researchers considering 5-Iodo-2,4-dimethylbenzoic acid for their work, several practical considerations should be noted. The compound is typically supplied as an off-white to light yellow powder, stable at room temperature when stored properly in airtight containers protected from light. Its shelf life can extend to several years under optimal conditions. When planning reactions, the iodine substituent's potential participation in various transformation reactions should be carefully evaluated to achieve desired synthetic outcomes.

In conclusion, 5-Iodo-2,4-dimethylbenzoic acid (CAS No. 742081-03-4) represents an important tool in modern chemical synthesis, particularly for pharmaceutical applications. Its unique combination of substituents offers multiple points for chemical modification, making it valuable for creating diverse molecular architectures. As research continues to explore new applications for iodoaromatic compounds, this chemical entity is likely to maintain its relevance in scientific innovation and drug discovery efforts worldwide.

• 886499-25-8(Benzoic acid, 2-formyl-5-iodo-)
• 1052647-27-4(Methyl 5-iodo-2,4-dimethylbenzoate)
• 6937-34-4(3-Iodophthalic acid)
• 54811-38-0(5-Iodo-2-methylbenzoic acid)
• 82998-57-0(3-Iodo-4-methylbenzoic acid)
• 129833-31-4(3,4-Dimethyl-2-iodobenzoic Acid)
• 133232-56-1(3-iodo-2-methyl-benzoic acid)
• 6301-60-6(4-Iodophthalic acid)
• 90259-33-9(Benzoic acid, 2-iodo-6-methyl-, sodium salt (1:1))
• 5613-33-2(5-Iodo-2,3-dimethylbenzoic Acid)