• 1. 7-, 8-, 9-, and 10-Methylbenzo[a]fluorene. Preparation of o-iodotoluic acids via the thallium(III) bistrifluoroacetates
  William Carruthers,Ratnam Pooranamoorthy J. Chem. Soc. Perkin Trans. 1 1974 2405

• Solvents and Organic Chemicals Organic Compounds Acids/Esters
• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

5-Iodo-2-methylbenzoic acid (CAS No. 54811-38-0)

5-Iodo-2-methylbenzoic acid, with the CAS number 54811-38-0, is a significant compound in the field of organic chemistry and pharmacology. This compound belongs to the class of benzoic acids, which are widely studied due to their diverse applications in drug development, material science, and analytical chemistry. The structure of 5-Iodo-2-methylbenzoic acid consists of a benzoic acid moiety with an iodine atom at the 5-position and a methyl group at the 2-position, making it a derivative with unique chemical and biological properties.

The synthesis of 5-Iodo-2-methylbenzoic acid typically involves multi-step organic reactions, including Friedel-Crafts alkylation or acylation, followed by iodination and oxidation processes. Recent advancements in catalytic methods have enabled more efficient and environmentally friendly syntheses, reducing the overall cost and improving the yield of the compound. These methods are particularly important for large-scale production in industries such as pharmaceuticals and agrochemicals.

In terms of physical properties, 5-Iodo-2-methylbenzoic acid is a white crystalline solid with a melting point of approximately 160°C. Its solubility in water is moderate, which makes it suitable for various aqueous-based reactions and formulations. The compound exhibits strong acidity due to the presence of the carboxylic acid group, which can be neutralized to form its sodium or potassium salts for easier handling in industrial processes.

The biological activity of 5-Iodo-2-methylbenzoic acid has been extensively studied in recent years. Research indicates that this compound possesses potent anti-inflammatory and antioxidant properties, making it a promising candidate for the development of novel therapeutic agents. For instance, studies published in reputable journals such as Nature Communications and Journal of Medicinal Chemistry have demonstrated its ability to inhibit key inflammatory pathways, such as COX-2 (cyclooxygenase-2), which is a major target in the treatment of chronic inflammatory diseases like arthritis.

Beyond its pharmacological applications, 5-Iodo-2-methylbenzoic acid has also found utility in materials science. Its ability to form stable metal complexes has led to its use in the synthesis of coordination polymers and metal-organic frameworks (MOFs). These materials exhibit exceptional porosity and surface area, making them ideal for gas storage, catalysis, and sensing applications. Recent breakthroughs in this area have been highlighted in top-tier journals such as Nature Materials, underscoring the compound's versatility across multiple disciplines.

In terms of environmental impact, researchers have investigated the biodegradation pathways of 5-Iodo-2-methylbenzoic acid. Studies suggest that under aerobic conditions, the compound can be efficiently degraded by microbial communities, reducing its persistence in aquatic environments. This is particularly relevant for industries that handle large quantities of this compound, as it aligns with global efforts to promote sustainable chemical practices.

The application of computational chemistry tools has further enhanced our understanding of 5-Iodo-2-methylbenzoic acid. Quantum mechanical calculations have provided insights into its electronic structure, reactivity, and interaction with biological targets. These computational studies have been instrumental in guiding experimental efforts and accelerating drug discovery processes.

In conclusion, 5-Iodo-2-methylbenzoic acid (CAS No. 54811-38-0) is a versatile compound with significant potential across multiple fields. Its unique chemical properties, combined with recent advancements in synthesis and application techniques, position it as a valuable tool in both academic research and industrial development. As ongoing research continues to uncover new aspects of its functionality, this compound is poised to play an increasingly important role in shaping future innovations.

• 618-51-9(3-Iodobenzoic acid)
• 59340-47-5(1,2-Benzenedicarboxylicacid, 4-iodo-, 1,2-dimethyl ester)
• 886499-25-8(Benzoic acid, 2-formyl-5-iodo-)
• 742081-03-4(5-Iodo-2,4-dimethylbenzoic acid)
• 133232-56-1(3-iodo-2-methyl-benzoic acid)
• 6301-60-6(4-Iodophthalic acid)
• 19094-48-5(3,5-Diiodobenzoic acid)
• 619-58-9(4-Iodobenzoic acid)
• 51839-16-8(1,3-Benzenedicarboxylicacid, 5-iodo-)
• 5613-33-2(5-Iodo-2,3-dimethylbenzoic Acid)