Production Method 1

1872395-39-5

742049-41-8

14996-02-2

Reaction Conditions

1.1 Solvents: Methanol ,  Water ;  60 - 80 min, 0 - 5 °C

Reference

A process for the preparation of isavuconazonium sulfate

, World Intellectual Property Organization, , ,

Production Method 2

741241-71-4

14996-02-2

742049-41-8

14996-02-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethyl acetate ,  Water ;  0 - 10 °C; 10 °C → 30 °C; 2 h, 30 °C

Reference

Preparation of isavuconazonium monosulfate by bisulfate/sulfate anion exchange technology

, China, , ,

Production Method 3

14808-79-8

741241-71-4

742049-41-8

14996-02-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethyl acetate ,  Water ;  0 - 10 °C; 0 °C → 60 °C; 2 h, 60 °C

Reference

Method for preparing isavuconazonium sulfate by oxidation-reduction reaction

, China, , ,

Production Method 4

742049-41-8

15181-48-3

742049-41-8

14996-02-2

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydrogen Catalysts: Palladium Solvents: Water ;  rt; cooled
1.2 Reagents: Sulfuric acid Solvents: Water

Reference

Preparation of isavuconazonium sulfate

, China, , ,

Production Method 5

742049-41-8

14996-02-2

Reaction Conditions

Reference

Preparation of (2-(methylamino)pyridin-3-yl)methanol as intermediate for preparing isavuconazonium sulfate as antifungal agents

, China, , ,

Production Method 6

742049-41-8

14996-02-2

Reaction Conditions

Reference

Isavuconazonium salts and process for preparing thereof

, World Intellectual Property Organization, , ,

Production Method 7

742049-41-8

14477-72-6

742049-41-8

14996-02-2

Reaction Conditions

1.1 Reagents: Sodium bisulfate Solvents: Dichloromethane ,  Water ;  0.5 - 1 h, 0 - 10 °C

Reference

Preparation of isavuconazonium sulfate

, World Intellectual Property Organization, , ,

Production Method 8

338990-64-0

742049-41-8

14996-02-2

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethanol ,  Water ;  2 h, rt

Reference

Preparation of isavuconazole sulfate

, China, , ,

Production Method 9

338990-31-1

241479-67-4

742049-41-8

14996-02-2

Reaction Conditions

1.1 Reagents: Sodium iodide Solvents: Acetonitrile ;  rt → 70 °C; 3 h, 70 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  rt; 2 h, rt
1.3 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water ;  0 °C; pH 6.5, < 5 °C
1.4 Solvents: Dichloromethane ,  Water ;  1 h, 15 °C

Reference

Method for preparing antifungal drug isavuconazonium sulfate

, China, , ,

Production Method 10

338990-63-9

742049-41-8

14996-02-2

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  25 - 30 °C

Reference

Process for the preparation of isavuconazonium sulfate

, India, , ,

Production Method 11

742049-41-8

14996-02-2

Reaction Conditions

Reference

Crystalline form of isavuconazonium sulfate and a process for its preparation

, India, , ,

Production Method 12

742049-41-8

14996-02-2

Reaction Conditions

Reference

Preparation of isavuconazonium sulfate

, China, , ,

Production Method 13

742049-41-8

14996-02-2

Reaction Conditions

Reference

Preparation of isavuconazonium sulfate and intermediates thereof

, China, , ,

Isavuconazonium Raw materials

• Sulfate (7CI,8CI,9CI)
• 4-(1-(3-(N-(t-Butoxycarbonyl)-N-methylglycyloxy)methyl)pyridin-2-yl(methyl)carbamoyl)oxy)ethyl)-1-(2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)2-hydroxybutyl1-(1,2,4-triazol) Iodide
• 4-(1-(((3-((2-((tert-butoxycarbonyl)(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium chloride
• NND-2252305
• Isavuconazonium
• (2-(((1-Chloroethoxy)carbonyl)(methyl)amino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
• Chlorosulfate
• Sulfate, hydrogen(8CI,9CI)
• Isavuconazole
• Acetic acid,2,2,2-trifluoro-, ion(1-)
• Isavuconazonium iodide hydrochloride

Isavuconazonium Preparation Products

• Isavuconazonium (742049-41-8)
• Sulfate, hydrogen(8CI,9CI) (14996-02-2)

• 1. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 2. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 3. Emerging investigators
  Polym. Chem., 2015,6, 5501-5502
• 4. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409
• 5. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608

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