Production Method 1

14996-02-2

742049-41-8

Reaction Conditions

1.1 Solvents: Methanol ,  Water ;  60 - 80 min, 0 - 5 °C

Reference

A process for the preparation of isavuconazonium sulfate

, World Intellectual Property Organization, , ,

Production Method 2

742049-41-8

14996-02-2

742049-41-8

Reaction Conditions

1.1 Reagents: Sodium bisulfate Solvents: Dichloromethane ,  Water ;  0.5 - 1 h, 0 - 10 °C

Reference

Preparation of isavuconazonium sulfate

, World Intellectual Property Organization, , ,

Production Method 3

338990-64-0

14996-02-2

742049-41-8

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethanol ,  Water ;  2 h, rt

Reference

Preparation of isavuconazole sulfate

, China, , ,

Production Method 4

741241-71-4

14996-02-2

14996-02-2

742049-41-8

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethyl acetate ,  Water ;  0 - 10 °C; 10 °C → 30 °C; 2 h, 30 °C

Reference

Preparation of isavuconazonium monosulfate by bisulfate/sulfate anion exchange technology

, China, , ,

Production Method 5

14808-79-8

741241-71-4

14996-02-2

742049-41-8

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Ethyl acetate ,  Water ;  0 - 10 °C; 0 °C → 60 °C; 2 h, 60 °C

Reference

Method for preparing isavuconazonium sulfate by oxidation-reduction reaction

, China, , ,

Production Method 6

338990-31-1

241479-67-4

14996-02-2

742049-41-8

Reaction Conditions

1.1 Reagents: Sodium iodide Solvents: Acetonitrile ;  rt → 70 °C; 3 h, 70 °C
1.2 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  rt; 2 h, rt
1.3 Reagents: Sodium bicarbonate Solvents: Dichloromethane ,  Water ;  0 °C; pH 6.5, < 5 °C
1.4 Solvents: Dichloromethane ,  Water ;  1 h, 15 °C

Reference

Method for preparing antifungal drug isavuconazonium sulfate

, China, , ,

Production Method 7

742049-41-8

15181-48-3

14996-02-2

742049-41-8

Reaction Conditions

1.1 Reagents: Sodium hydroxide ,  Hydrogen Catalysts: Palladium Solvents: Water ;  rt; cooled
1.2 Reagents: Sulfuric acid Solvents: Water

Reference

Preparation of isavuconazonium sulfate

, China, , ,

Production Method 8

14996-02-2

742049-41-8

Reaction Conditions

Reference

Preparation of isavuconazonium sulfate

, China, , ,

Production Method 9

14996-02-2

742049-41-8

Reaction Conditions

Reference

Isavuconazonium salts and process for preparing thereof

, World Intellectual Property Organization, , ,

Production Method 10

6596-81-2

14996-02-2

45470-32-4

21228-90-0

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Methanol

Reference

Thiono compounds. 5. Preparation and oxidation of some thiono derivatives of imidazoles

Karkhanis, Dattatraya W.; Field, Lamar, Phosphorus and Sulfur and the Related Elements, 1985, 22(1), 49-57

Production Method 11

1633-83-6

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 Solvents: Toluene ;  10 h, reflux; reflux → rt
1.2 Reagents: Sulfuric acid ;  0 - 2 °C; 40 °C

Reference

Ionic Liquids as Catalyst for Synthesis of Some Aromatic Peracetylated N-(β-D-Glucopyranosyl) Thiosemicarbazones

Thanh, Nguyen Dinh; et al, Current Organic Synthesis, 2016, 13(5), 767-774

Production Method 12

1633-83-6

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 12 h, 80 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  6 h, 60 °C

Reference

Kinetics Study of the Ketalization Reaction of Cyclohexanone with Glycol Using Bronsted Acidic Ionic Liquids as Catalysts

Tao, Duan-Jian; et al, Industrial & Engineering Chemistry Research, 2012, 51(50), 16263-16269

Production Method 13

657414-79-4

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  overnight, 60 °C

Reference

Pd-catalyzed ethylene methoxycarbonylation with Bronsted acid ionic liquids as promoter and phase-separable reaction media

Garcia-Suarez, Eduardo J.; et al, Green Chemistry, 2014, 16(1), 161-166

Production Method 14

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 12 h, 40 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  rt; 6 h, 80 °C

Reference

Broensted acidic ionic liquids as novel catalysts for the hydrolyzation of soybean isoflavone glycosides

Yang, Qiwei; et al, Catalysis Communications, 2008, 9(6), 1307-1311

Production Method 15

1072-63-5

1633-83-6

14996-02-2

657414-79-4

Reaction Conditions

1.1 0 °C; 12 h, rt
2.1 Reagents: Sulfuric acid Solvents: Water ;  0 °C; 24 h, 50 °C

Reference

Polypyrrole nanocomposites doped with functional ionic liquids for high performance supercapacitors

Cao, Peng; et al, New Journal of Chemistry, 2018, 42(5), 3909-3916

Production Method 16

179863-07-1

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sulfuric acid ;  2 h
2.1 Reagents: Tetraethoxysilane Solvents: Ethanol ;  10 min, rt; 1 w, rt; 3 w, rt
2.2 Solvents: Ethanol ;  2 h, reflux

Reference

Efficient synthesis of 4-phenacylideneflavenes using recyclable gelified Bronsted acidic ionic liquid under solvent-free and column chromatography-free conditions: a green method and mechanistic insight

Nguyen, Xuan-Trang T.; et al, Journal of Chemical Technology and Biotechnology, 2022, 97(3), 653-661

Production Method 17

14996-02-2

657414-79-4

Reaction Conditions

1.1 Solvents: Ethanol ;  2 d
2.1 0 °C; 2 - 3 d, 50 °C
3.1 Reagents: Sulfuric acid ;  0 °C; 1 - 2 d, 50 °C

Reference

Synthesis of polyoxymethylene dimethyl ethers from methylal and trioxane catalyzed by Bronsted acid ionic liquids with different alkyl groups

Wu, Qin; et al, RSC Advances, 2015, 5(71), 57968-57974

Production Method 18

1633-83-6

616-47-7

14996-02-2

657414-79-4

14066-20-7

Reaction Conditions

1.1 Solvents: Acetone ;  72 h, 25 °C; 72 h, 50 °C
1.2 Reagents: Phosphoric acid ;  rt

Reference

A green way to synthesize lubricating ester oils: The esterification of pentaerythrotol with fatty acids at stoichiometric ratio over [BHSO3MMIm]+[HSO4]-/SiO2

Wang, Yanan; et al, Catalysis Communications, 2018, 111, 21-25

Production Method 19

338990-63-9

14996-02-2

742049-41-8

Reaction Conditions

1.1 Reagents: Hydrochloric acid Solvents: Ethyl acetate ;  25 - 30 °C

Reference

Process for the preparation of isavuconazonium sulfate

, India, , ,

Production Method 20

14996-02-2

742049-41-8

Reaction Conditions

Reference

Crystalline form of isavuconazonium sulfate and a process for its preparation

, India, , ,

Production Method 21

14996-02-2

742049-41-8

Reaction Conditions

Reference

Preparation of (2-(methylamino)pyridin-3-yl)methanol as intermediate for preparing isavuconazonium sulfate as antifungal agents

, China, , ,

Production Method 22

14996-02-2

742049-41-8

Reaction Conditions

Reference

Preparation of isavuconazonium sulfate and intermediates thereof

, China, , ,

Production Method 23

1633-83-6

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 12 h, 80 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  12 h, 80 °C

Reference

Anionic SO3H-functionalized ionic liquid: An efficient and recyclable catalyst for the Pechmann reaction of phenols with ethyl acetoacetate

Song, Dayong; et al, Synthetic Communications, 2018, 48(6), 692-698

Production Method 24

179863-07-1

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Toluene ;  rt; 24 h, 80 °C

Reference

Bronsted Acidic Ionic Liquid Catalyzed Three-Component Friedel-Crafts Reaction for the Synthesis of Unsymmetrical Triarylmethanes

Rinkam, Suttida; et al, Synlett, 2022, 33(14), 1383-1390

Production Method 25

179863-07-1

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  12 h, 60 °C

Reference

Groebke-Blackburn-Bienayme Multicomponent Reaction Catalysed by Reusable Bronsted acidic ionic Liquids

Anjos, Nicolas S.; et al, European Journal of Organic Chemistry, 2022, 2022(40),

Production Method 26

657414-79-4

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  rt; 6 h, 80 °C

Reference

Reusable Task-Specific Ionic Liquids for a Clean ε-Caprolactam Synthesis under Mild Conditions

Turgis, Raphael; et al, ChemSusChem, 2010, 3(12), 1403-1408

Production Method 27

65180-31-6

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Water ;  0 °C; 24 h, 50 °C

Reference

Polypyrrole nanocomposites doped with functional ionic liquids for high performance supercapacitors

Cao, Peng; et al, New Journal of Chemistry, 2018, 42(5), 3909-3916

Production Method 28

1633-83-6

14996-02-2

657414-79-4

Reaction Conditions

1.1 8 h, heated
1.2 Reagents: Sulfuric acid Solvents: Water ;  8 h, heated

Reference

Catalytic performance of acidic ionic liquids for esterification of α-methacrylic acid and stearyl alcohol

Peng, Jiani; et al, Shiyou Xuebao, 2016, 32(1), 193-200

Production Method 29

1633-83-6

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 Solvents: Toluene ;  24 h, reflux
1.2 Reagents: Sulfuric acid Solvents: Water ;  24 h, 70 °C

Reference

Nanosilica-supported dual acidic ionic liquid as a heterogeneous and reusable catalyst for the synthesis of flavanones under solvent-free conditions

Rostamizadeh, Shahnaz; et al, Chemistry of Heterocyclic Compounds (New York, 2015, 51(6), 526-530

Production Method 30

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 Solvents: Toluene ;  3 h, 80 °C
1.2 Reagents: Sulfuric acid Solvents: Water ;  2 h, rt

Reference

Synthesis of tributyl citrate using acid ionic liquid as catalyst

Xu, Junming; et al, Process Safety and Environmental Protection, 2010, 88(1), 28-30

Production Method 31

657414-79-4

14996-02-2

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Tetraethoxysilane Solvents: Ethanol ;  10 min, rt; 1 w, rt; 3 w, rt
1.2 Solvents: Ethanol ;  2 h, reflux

Reference

Efficient synthesis of 4-phenacylideneflavenes using recyclable gelified Bronsted acidic ionic liquid under solvent-free and column chromatography-free conditions: a green method and mechanistic insight

Nguyen, Xuan-Trang T.; et al, Journal of Chemical Technology and Biotechnology, 2022, 97(3), 653-661

Production Method 32

14996-02-2

657414-79-4

Reaction Conditions

1.1 Solvents: Ethanol ;  2 d, heated
2.1 0 °C; 2 - 3 d, 50 °C
2.2 Reagents: Sulfuric acid ;  0 °C; 1 - 2 d, 50 °C

Reference

Synthesis of methylal from methanol and formaldehyde catalyzed by Bronsted acid ionic liquids with different alkyl groups

Sun, Jiahan; et al, RSC Advances, 2015, 5(106), 87200-87205

Production Method 33

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sulfuric acid Solvents: Toluene ;  80 °C
2.1 Reagents: Sulfuric acid

Reference

A non-metal route to realize the bio-based polyester of poly(hexylene succinate): preparation conditions, side-reactions and mechanism in sulfonic acid-functionalized Bronsted acidic ionic liquids

Wei, Chenyang; et al, RSC Advances, 2020, 10(58), 35381-35388

Production Method 34

1633-83-6

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 1 h, 80 °C
2.1 Reagents: Sulfuric acid ;  2 h
3.1 Reagents: Tetraethoxysilane Solvents: Ethanol ;  10 min, rt; 1 w, rt; 3 w, rt
3.2 Solvents: Ethanol ;  2 h, reflux

Reference

Efficient synthesis of 4-phenacylideneflavenes using recyclable gelified Bronsted acidic ionic liquid under solvent-free and column chromatography-free conditions: a green method and mechanistic insight

Nguyen, Xuan-Trang T.; et al, Journal of Chemical Technology and Biotechnology, 2022, 97(3), 653-661

Production Method 35

288-32-4

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sodium ethoxide ;  8 h, heated
2.1 Solvents: Ethanol ;  2 d, heated
3.1 0 °C; 2 - 3 d, 50 °C
3.2 Reagents: Sulfuric acid ;  0 °C; 1 - 2 d, 50 °C

Reference

Synthesis of methylal from methanol and formaldehyde catalyzed by Bronsted acid ionic liquids with different alkyl groups

Sun, Jiahan; et al, RSC Advances, 2015, 5(106), 87200-87205

Production Method 36

288-32-4

14996-02-2

657414-79-4

Reaction Conditions

1.1 Reagents: Sodium ethoxide ;  8 h
2.1 Solvents: Ethanol ;  2 d
3.1 0 °C; 2 - 3 d, 50 °C
4.1 Reagents: Sulfuric acid ;  0 °C; 1 - 2 d, 50 °C

Reference

Synthesis of polyoxymethylene dimethyl ethers from methylal and trioxane catalyzed by Bronsted acid ionic liquids with different alkyl groups

Wu, Qin; et al, RSC Advances, 2015, 5(71), 57968-57974

Production Method 37

1633-83-6

616-47-7

14996-02-2

657414-79-4

Reaction Conditions

1.1 Solvents: Acetone ;  72 h, 25 °C; 72 h, 50 °C
1.2 rt

Reference

A green way to synthesize lubricating ester oils: The esterification of pentaerythrotol with fatty acids at stoichiometric ratio over [BHSO3MMIm]+[HSO4]-/SiO2

Wang, Yanan; et al, Catalysis Communications, 2018, 111, 21-25

Sulfate, hydrogen(8CI,9CI) Raw materials

• Imidazole
• Sulfate (7CI,8CI,9CI)
• 4-(1-(3-(N-(t-Butoxycarbonyl)-N-methylglycyloxy)methyl)pyridin-2-yl(methyl)carbamoyl)oxy)ethyl)-1-(2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)2-hydroxybutyl1-(1,2,4-triazol) Iodide
• 4-(1-(((3-((2-((tert-butoxycarbonyl)(methyl)amino)acetoxy)methyl)pyridin-2-yl)(methyl)carbamoyl)oxy)ethyl)-1-((2R,3R)-3-(4-(4-cyanophenyl)thiazol-2-yl)-2-(2,5-difluorophenyl)-2-hydroxybutyl)-1H-1,2,4-triazol-4-ium chloride
• NND-2252305
• Isavuconazonium
• (2-(((1-Chloroethoxy)carbonyl)(methyl)amino)pyridin-3-yl)methyl 2-((tert-butoxycarbonyl)(methyl)amino)acetate
• Chlorosulfate
• 1H-Imidazolium, 1-methyl-3-(4-sulfobutyl)-
• Sulfate, hydrogen(8CI,9CI)
• Isavuconazole
• 4-(1-Vinyl-1h-imidazol-3-ium-3-yl)butane-1-sulfonate
• 1-Methylimidazolium sulfobutyrolactone
• 1-Vinylimidazole
• 1,4-Butane sulton
• 1-Methylimidazole
• 1,3-dimethylimidazole-2(3h)-thione

Sulfate, hydrogen(8CI,9CI) Preparation Products

• Isavuconazonium (742049-41-8)
• 1H-Imidazolium, 1-methyl-3-(4-sulfobutyl)- (657414-79-4)
• Sulfate, hydrogen(8CI,9CI) (14996-02-2)
• Phosphate, dihydrogen(8CI,9CI) (14066-20-7)
• 1,3-Dimethylimidazolium (45470-32-4)
• [(Sulfuric acid methyl)ion] (21228-90-0)

• 1. Tb(HSO4)(SO4) – a green emitting hydrogensulfate sulfate with second harmonic generation response
  Philip Netzsch,Harijs Bariss,Lkhamsuren Bayarjargal,Henning A. H?ppe Dalton Trans. 2019 48 16377
• 2. Molecular interactions between ammonium-based ionic liquids and molecular solvents: current progress and challenges
  Varadhi Govinda,Pannuru Venkatesu,Indra Bahadur Phys. Chem. Chem. Phys. 2016 18 8278
• 3. Water and oxoanion encapsulation chemistry in a 1H-pyrazole azacryptand
  Javier Pitarch-Jarque,Kari Rissanen,Santiago García-Granda,Alberto Lopera,M. Paz Clares,Enrique García-Espa?a,Salvador Blasco New J. Chem. 2019 43 18915
• 4. Cobalt(ii)/nickel(ii) separation from sulfate media by solvent extraction with an undiluted quaternary phosphonium ionic liquid
  Bieke Onghena,Stijn Valgaeren,Tom Vander Hoogerstraete,Koen Binnemans RSC Adv. 2017 7 35992
• 5. Design of low-cost ionic liquids for lignocellulosic biomass pretreatment
  Anthe George,Agnieszka Brandt,Kim Tran,Shahrul M. S. Nizan S. Zahari,Daniel Klein-Marcuschamer,Ning Sun,Noppadon Sathitsuksanoh,Jian Shi,Vitalie Stavila,Ramakrishnan Parthasarathi,Seema Singh,Bradley M. Holmes,Tom Welton,Blake A. Simmons,Jason P. Hallett Green Chem. 2015 17 1728

• 13813-19-9(Sulfuric acid-d2)
• 7446-33-5(Yttrium(III) sulfate octahydrate)
• 7783-20-2(Ammonium sulfate)
• 13814-01-2(Ammonium-d8 Sulfate)
• 43086-58-4(Ammonium sulphate,≥99.0%,AR-)
• 13701-70-7(Sulfuric acid,vanadium(3+) salt (3:2))
• 7778-80-5(Potassium Sulphate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)