Cas no 71989-33-8 (Fmoc-Ser(tBu)-OH)

Fmoc-Ser(tBu)-OH is a protected serine derivative widely used in solid-phase peptide synthesis (SPPS). The Fmoc (9-fluorenylmethoxycarbonyl) group serves as an N-terminal protecting group, removable under basic conditions, while the tBu (tert-butyl) group protects the hydroxyl side chain of serine, stable to bases but cleavable under acidic conditions. This orthogonal protection strategy enables selective deprotection during peptide assembly, ensuring high coupling efficiency and minimizing side reactions. The compound is particularly valuable in synthesizing complex peptides requiring precise side-chain protection. Its stability, compatibility with standard SPPS protocols, and reliable deprotection make it a preferred choice for researchers in peptide chemistry and pharmaceutical development.

Fmoc-Ser(tBu)-OH structure

Product Name:Fmoc-Ser(tBu)-OH

CAS No:71989-33-8

MF:C₂₂H₂₅NO₅

MW:383.437606573105

MDL:MFCD00037127

CID:59296

PubChem ID:2724633

Update Time:2025-12-23

Fmoc-Ser(tBu)-OH Chemical and Physical Properties

Names and Identifiers

- Fmoc-O-tert-butyl-L-serine
- N-(9-Fluorenylmethoxycarbonyl)-O-tert-butyl-L-serine
- O-tert-Butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine
- (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-[(2-methylpropan-2-yl)oxy]propanoic acid
- (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(tert-butoxy)propanoic acid
- 9-FLUORENYLMETHOXYCARBONYL-O-T-BUTYL-L-SERINE
- Fmoc-L-Ser(tBu)-OH
- FMOC-SER(BUT)-OH
- Fmoc--Ser(tBu)-OH
- Fmoc-Ser(tBu)-OH
- FMoc-Ser(tBu)-OHFMoc-O-tert·butyl-L-serine
- O-tert-Butyl-N-Fmoc-L-serine
- Fmoc-Ser(t-Bu)-OH
- Fmoc-Ser(But)
- Fmoc-O-tert.butyl-L-serine
- Fmoc-Ser(tBu)
- PubChem10035
- Fmoc-L-Ser(OtBu)OH
- N-(((9H-fluoren-9-yl)methoxy)carbonyl)-O-(tert-butyl)-L-serine
- Fmoc-O-(tert-butyl)-L-serine
- Fmoc-L-Ser(OtBu)-OH
- n-fmoc-o-tert-butylserine
- n-fmoc-o-t-butyl-l-serine
- KSC377O3N
- Fmoc-Ser(tBu)-OH,98%
- MDL： MFCD00037127
- Inchi： 1S/C22H25NO5/c1-22(2,3)28-13-19(20(24)25)23-21(26)27-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,18-19H,12-13H2,1-3H3,(H,23,26)(H,24,25)/t19-/m0/s1
- InChI Key： REITVGIIZHFVGU-IBGZPJMESA-N
- SMILES： O(C(N[C@H](C(=O)O)COC(C)(C)C)=O)CC1C2C=CC=CC=2C2C=CC=CC1=2
- BRN： 3632013

Computed Properties

Exact Mass: 383.17300
Monoisotopic Mass: 383.173
Isotope Atom Count: 0
Hydrogen Bond Donor Count: 2
Hydrogen Bond Acceptor Count: 5
Heavy Atom Count: 28
Rotatable Bond Count: 8
Complexity: 536
Covalently-Bonded Unit Count: 1
Defined Atom Stereocenter Count: 0
Undefined Atom Stereocenter Count : 0
Defined Bond Stereocenter Count: 0
Undefined Bond Stereocenter Count: 0
Topological Polar Surface Area: 84.9
Surface Charge: -1
XLogP3: 4.2

Experimental Properties

Color/Form: White powder
Density: 1.217
Melting Point: 127-131 oC
Boiling Point: 510.36°C (rough estimate)
Flash Point: 303.7 °C
Refractive Index: 1.575
PSA: 84.86000
LogP: 4.18430
Specific Rotation: 25 o (c=1,EtOAc 24 oC)
Optical Activity: [α]20/D +25.5±1°, c =?1% in ethyl acetate
Solubility: Not determined

Fmoc-Ser(tBu)-OH Security Information

Signal Word：Warning
Hazard Statement： H315-H319-H335
Warning Statement： P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501
Hazardous Material transportation number：NONH for all modes of transport
WGK Germany：3
Hazard Category Code： 36/37/38
Safety Instruction： S24/25; S36/37/39; S27; S26
Hazardous Material Identification：
Storage Condition：2-8°C
Risk Phrases：R36/37/38
Safety Term：S24/25

Fmoc-Ser(tBu)-OH Customs Data

HS CODE：2924299090
Customs Data：

China Customs Code:
2924299090

Overview:

2924299090. Other cyclic amides(Including cyclic carbamates)(Including their derivatives as well as their salts). VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:30.0%

Declaration elements:

Product Name, component content, use to, packing

Summary:

2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Fmoc-Ser(tBu)-OH Pricemore >>

Related Categories	No.	Product Name	Cas No.	Purity	Specification	Price	update time
SHANG HAI XIAN DING Biotechnology Co., Ltd.	A-JP794-5g	Fmoc-Ser(tBu)-OH	71989-33-8	98%	5g	78CNY	2021-05-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	A-JP794-100g	Fmoc-Ser(tBu)-OH	71989-33-8	98%	100g	903CNY	2021-05-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	A-JP794-25g	Fmoc-Ser(tBu)-OH	71989-33-8	98%	25g	236CNY	2021-05-10
SHANG HAI XIAN DING Biotechnology Co., Ltd.	A-JP794-1g	Fmoc-Ser(tBu)-OH	71989-33-8	98%	1g	47CNY	2021-05-10
TI XI AI ( SHANG HAI ) HUA CHENG GONG YE FA ZHAN Co., Ltd.	B3168-25G	O-tert-Butyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-L-serine	71989-33-8	>98.0%(T)(HPLC)	25g	￥320.00	2024-04-15
TRC	F861048-1g	Fmoc-Ser(tBu)-OH	71989-33-8		1g	$ 50.00	2022-06-04
TRC	F861048-5g	Fmoc-Ser(tBu)-OH	71989-33-8		5g	$ 60.00	2022-06-04
TRC	F861048-25g	Fmoc-Ser(tBu)-OH	71989-33-8		25g	$ 70.00	2022-06-04
TRC	F861048-100g	Fmoc-Ser(tBu)-OH	71989-33-8		100g	$184.00	2023-05-18
SHANG HAI JI ZHI SHENG HUA Technology Co., Ltd.	F35680-5g	Fmoc-Ser(tBu)-OH	71989-33-8	97%	5g	￥28.0	2023-09-07

Fmoc-Ser(tBu)-OH Production Method

Fmoc-Ser(tBu)-OH Suppliers

Suzhou Senfeida Chemical Co., Ltd

Gold Member

Audited Supplier

(CAS:71989-33-8)FMOC-O-tert-Butyl-L-serine

Order Number:sfd9790

Stock Status:in Stock

Quantity:200kg

Purity:99.9%

Pricing Information Last Updated:Friday, 19 July 2024 14:35

Price ($):discuss personally

Email:[email protected]

Product Official Link

Tiancheng Chemical (Jiangsu) Co., Ltd

Gold Member

Audited Supplier

(CAS:71989-33-8)FMOC-O-叔丁基-L-絲氨酸

Order Number:LE25900890

Stock Status:in Stock

Quantity:25KG,200KG,1000KG

Purity:99%

Pricing Information Last Updated:Friday, 20 June 2025 12:51

Price ($):discuss personally

Email:[email protected]

Fmoc-Ser(tBu)-OH Spectrogram

13C NMR

1H NMR

300 MHz

DMSO

Fmoc-Ser(tBu)-OH Related Literature

1. Selective aliphatic/aromatic organogelation controlled by the side chain of serine amphiphiles

Jessica Ramos,Santiago Arufe,Róisín O'Flaherty,Denise Rooney,Ramon Moreira,Trinidad Velasco-Torrijos RSC Adv. 2016 6 108093
2. Non-Kolbe electrolysis of N-protected-α-amino acids: a standardized method for the synthesis of N-protected (1-methoxyalkyl)amines

A. Wal?cka-Kurczyk,J. Adamek,K. Walczak,M. Michalak,A. Pa?dzierniok-Holewa RSC Adv. 2022 12 2107
3. Unveiling and tackling guanidinium peptide coupling reagent side reactions towards the development of peptide-drug conjugates

Eirinaios I. Vrettos,Nisar Sayyad,Eftychia M. Mavrogiannaki,Evgenios Stylos,Androniki D. Kostagianni,Serafim Papas,Thomas Mavromoustakos,Vassiliki Theodorou,Andreas G. Tzakos RSC Adv. 2017 7 50519
4. Sonogashira and “Click” reactions for the N-terminal and side-chain functionalization of peptides with [Mn(CO)3(tpm)]+-based CO releasing molecules (tpm = tris(pyrazolyl)methane)

Hendrik Pfeiffer,Alfonso Rojas,Johanna Niesel,Ulrich Schatzschneider Dalton Trans. 2009 4292
5. Hg2+ and Cd2+ binding of a bioinspired hexapeptide with two cysteine units constructed as a minimalistic metal ion sensing fluorescent probe

Levente I. Szekeres,Sára Bálint,Gábor Galbács,Ildikó Kálomista,Tamás Kiss,Flemming H. Larsen,Lars Hemmingsen,Attila Jancsó Dalton Trans. 2019 48 8327

Related Categories

Additional information on Fmoc-Ser(tBu)-OH

Comprehensive Guide to Fmoc-Ser(tBu)-OH (CAS No. 71989-33-8): Properties, Applications, and Market Insights

Fmoc-Ser(tBu)-OH (CAS No. 71989-33-8) is a highly specialized amino acid derivative widely used in peptide synthesis, particularly in solid-phase peptide synthesis (SPPS). This compound is essential for researchers and pharmaceutical developers due to its unique protective groups—Fmoc (9-fluorenylmethoxycarbonyl) and tBu (tert-butyl)—which enhance stability and reactivity during peptide chain assembly. With the growing demand for therapeutic peptides and bioconjugates, understanding Fmoc-Ser(tBu)-OH is critical for advancements in drug discovery and biotechnology.

The chemical structure of Fmoc-Ser(tBu)-OH includes a serine backbone protected by an Fmoc group at the N-terminus and a tBu group on the hydroxyl side chain. This configuration prevents unwanted side reactions during peptide coupling, making it indispensable in automated peptide synthesizers. Researchers frequently search for "Fmoc-Ser(tBu)-OH solubility," "Fmoc-Ser(tBu)-OH protocol," and "Fmoc-Ser(tBu)-OH price," highlighting its practical importance in laboratories.

In recent years, the rise of personalized medicine and peptide-based therapeutics has increased the relevance of Fmoc-Ser(tBu)-OH. Peptides like semaglutide (used for diabetes and weight loss) and tirzepatide have spurred interest in efficient synthesis methods. This compound is also pivotal in developing antibody-drug conjugates (ADCs) and peptide vaccines, aligning with trends in cancer immunotherapy and infectious disease research.

The market for Fmoc-Ser(tBu)-OH is expanding, driven by pharmaceutical R&D and academic studies. Suppliers often list it under keywords like "Fmoc-Ser(tBu)-OH supplier" or "buy Fmoc-Ser(tBu)-OH," with purity (typically ≥98%) and batch consistency being key purchasing factors. Storage recommendations—such as keeping the compound at 2-8°C in a dry environment—are frequently queried, reflecting its sensitivity to moisture and temperature.

From a technical perspective, Fmoc-Ser(tBu)-OH is compatible with common coupling reagents like HBTU and DIC, and its molecular weight (339.38 g/mol) is critical for stoichiometric calculations. Users often seek "Fmoc-Ser(tBu)-OH MSDS" for safety data, though it is classified as non-hazardous under standard handling conditions. Its role in green chemistry initiatives—such as reducing solvent waste in SPPS—further elevates its profile in sustainable research practices.

In summary, Fmoc-Ser(tBu)-OH (CAS No. 71989-33-8) remains a cornerstone of modern peptide chemistry, bridging fundamental science and cutting-edge therapeutics. Its optimization continues to support breakthroughs in drug development, answering the demand for more efficient and scalable synthesis routes. For researchers, staying updated on its applications and handling protocols is essential to leverage its full potential.

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