Cas no 71406-72-9 ((2-Chloropyrimidin-4-yl)isopropylamine)
(2-Chloropyrimidin-4-yl)isopropylamine Chemical and Physical Properties
Names and Identifiers
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- 2-Chloro-N-isopropylpyrimidin-4-amine
- 2-CHLORO-N-(1-METHYLETHYL)PYRIMIDIN-4-AMINE
- 2-chloro-N-propan-2-ylpyrimidin-4-amine
- 2-chloro-N-isopropyl-4-pyrimidinamine(SALTDATA: FREE)
- AM101181
- EN300-1256679
- LTFNDXISRKPGHC-UHFFFAOYSA-N
- 2-chloro-N-(1-methylethyl)pyrimidin-4-amine, AldrichCPR
- 2-CHLORO-N-ISOPROPYL-4-PYRIMIDINAMINE
- 2-Chloro-N-(propan-2-yl)pyrimidin-4-amine
- SB55673
- WCA40672
- SCHEMBL1774897
- (2-Chloropyrimidin-4-yl)isopropylamine
- FT-0688686
- 71406-72-9
- MFCD09756901
- AKOS011628567
- (2-Chloro-pyrimidin-4-yl)-isopropyl-amine
- DTXSID80604641
-
- MDL： MFCD09756901
- Inchi： 1S/C7H10ClN3/c1-5(2)10-6-3-4-9-7(8)11-6/h3-5H,1-2H3,(H,9,10,11)
- InChI Key： LTFNDXISRKPGHC-UHFFFAOYSA-N
- SMILES： ClC1=NC=CC(=N1)NC(C)C
Computed Properties
- Exact Mass: 171.05600
- Monoisotopic Mass: 171.056
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 1
- Hydrogen Bond Acceptor Count: 3
- Heavy Atom Count: 11
- Rotatable Bond Count: 1
- Complexity: 118
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- Topological Polar Surface Area: 37.8A^2
- XLogP3: 2.3
Experimental Properties
- Density: 1.220
- Boiling Point: 322.2±15.0 °C at 760 mmHg
- Flash Point: 148.7±20.4 °C
- Refractive Index: 1.57
- PSA: 37.81000
- LogP: 2.02330
- Vapor Pressure: 0.0±0.7 mmHg at 25°C
(2-Chloropyrimidin-4-yl)isopropylamine Security Information
- Signal Word：warning
- Hazard Statement： H303May be harmful if swallowed+H313Skin contact may be harmful+H333Inhalation may be harmful to the body
- Warning Statement： P264+P280+P305+P351+P338+P337+P313
- Hazard Category Code： 22
- Safety Instruction： H303+H313+H333
-
Hazardous Material Identification：
- Storage Condition：storage at -4℃ (1-2weeks), longer storage period at -20℃ (1-2years)
(2-Chloropyrimidin-4-yl)isopropylamine Customs Data
- HS CODE：2933599090
- Customs Data：
China Customs Code:
2933599090Overview:
2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%
Declaration elements:
Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date
Summary:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
(2-Chloropyrimidin-4-yl)isopropylamine Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| TRC | C597925-50mg |
(2-Chloropyrimidin-4-yl)isopropylamine |
71406-72-9 | 50mg |
$ 50.00 | 2022-06-06 | ||
| TRC | C597925-100mg |
(2-Chloropyrimidin-4-yl)isopropylamine |
71406-72-9 | 100mg |
$ 70.00 | 2022-06-06 | ||
| TRC | C597925-500mg |
(2-Chloropyrimidin-4-yl)isopropylamine |
71406-72-9 | 500mg |
$ 275.00 | 2022-06-06 | ||
| Fluorochem | 088408-250mg |
2-Chloro-pyrimidin-4-yl)-isopropyl-amine |
71406-72-9 | 95% | 250mg |
￡124.00 | 2022-03-01 | |
| Fluorochem | 088408-1g |
2-Chloro-pyrimidin-4-yl)-isopropyl-amine |
71406-72-9 | 95% | 1g |
￡232.00 | 2022-03-01 | |
| Fluorochem | 088408-5g |
2-Chloro-pyrimidin-4-yl)-isopropyl-amine |
71406-72-9 | 95% | 5g |
￡744.00 | 2022-03-01 | |
| Chemenu | CM133566-1g |
2-chloro-N-isopropylpyrimidin-4-amine |
71406-72-9 | 95% | 1g |
$336 | 2021-08-05 | |
| Chemenu | CM133566-1g |
2-chloro-N-isopropylpyrimidin-4-amine |
71406-72-9 | 95% | 1g |
$210 | 2023-02-17 | |
| Crysdot LLC | CD11068365-1g |
2-Chloro-N-isopropylpyrimidin-4-amine |
71406-72-9 | 95+% | 1g |
$356 | 2024-07-18 | |
| SHANG HAI HAO HONG Biomedical Technology Co., Ltd. | 1766170-250mg |
2-Chloro-N-isopropylpyrimidin-4-amine |
71406-72-9 | 98% | 250mg |
￥5411.00 | 2024-05-02 |
(2-Chloropyrimidin-4-yl)isopropylamine Related Literature
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Brindha J.,Balamurali M. M.,Kaushik Chanda RSC Adv., 2019,9, 34720-34734
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Tengfei Yu,Yuehan Wu,Wei Li,Bin Li RSC Adv., 2014,4, 34134-34143
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Gloria Belén Ramírez-Rodríguez,José Manuel Delgado-López,Jaime Gómez-Morales CrystEngComm, 2013,15, 2206-2212
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Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
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Fereshteh Bayat Environ. Sci.: Nano, 2021,8, 367-389
Additional information on (2-Chloropyrimidin-4-yl)isopropylamine
(2-Chloropyrimidin-4-yl)isopropylamine (CAS No. 71406-72-9): A Versatile Building Block in Modern Organic Synthesis
The compound (2-Chloropyrimidin-4-yl)isopropylamine (CAS No. 71406-72-9) is a highly specialized heterocyclic amine derivative that has garnered significant attention in the fields of pharmaceutical intermediates, agrochemical research, and material science. Its unique molecular structure, featuring a chloropyrimidine core and an isopropylamine side chain, makes it a valuable precursor for the synthesis of more complex molecules. Researchers and industry professionals frequently search for this compound under variations such as "2-chloro-4-isopropylaminopyrimidine" or "71406-72-9 supplier", reflecting its niche yet critical role in synthetic chemistry.
In recent years, the demand for custom synthesis and high-purity intermediates like (2-Chloropyrimidin-4-yl)isopropylamine has surged, driven by advancements in drug discovery and precision agriculture. The compound's reactivity profile allows for selective modifications at the chlorine position or the amine group, enabling the creation of diverse derivatives. This adaptability aligns with current trends in fragment-based drug design (FBDD), where small molecular fragments serve as starting points for developing targeted therapies. Searches for "pyrimidine-based scaffolds in drug development" or "CAS 71406-72-9 applications" often highlight its relevance in these cutting-edge areas.
From a synthetic methodology perspective, 71406-72-9 exemplifies the growing importance of atom-efficient reactions and green chemistry principles. Its use in cross-coupling reactions, particularly Buchwald-Hartwig aminations or Suzuki-Miyaura couplings, demonstrates how this intermediate facilitates the construction of C-N and C-C bonds with high selectivity. These transformations are frequently explored in queries like "chloropyrimidine amination protocols" or "isopropylamine-substituted heterocycles", underscoring the compound's utility in modern catalytic processes.
The physicochemical properties of (2-Chloropyrimidin-4-yl)isopropylamine also contribute to its widespread adoption. With a balanced lipophilicity (logP) and hydrogen-bonding capacity, it serves as an ideal candidate for optimizing bioavailability in medicinal chemistry projects. Analytical techniques such as HPLC purity testing, NMR characterization, and mass spectrometry are commonly employed to verify its quality, as evidenced by search terms like "CAS 71406-72-9 analytical data" or "chloropyrimidine stability studies". These quality control measures ensure reproducibility in research and industrial applications.
Beyond pharmaceuticals, 71406-72-9 finds applications in specialty chemicals and functional materials. Its incorporation into liquid crystals or coordination polymers has been investigated for optoelectronic devices, responding to the increasing interest in organic electronics. Recent publications and patents referencing this compound often correlate with searches for "pyrimidine-based materials" or "heterocyclic building blocks for OLEDs", reflecting its cross-disciplinary utility.
As regulatory frameworks evolve, the importance of well-documented synthetic pathways for compounds like (2-Chloropyrimidin-4-yl)isopropylamine becomes paramount. Suppliers and researchers prioritize regulatory compliance and safety data sheets (SDS), as seen in search trends for "71406-72-9 handling guidelines" or "chloropyrimidine storage conditions". Proper documentation ensures seamless integration into global supply chains for research institutions and industrial manufacturers alike.
Looking ahead, the versatility of CAS 71406-72-9 positions it as a key player in emerging fields such as proteolysis-targeting chimeras (PROTACs) and covalent inhibitor design. Its structural motifs align with the demand for three-dimensional molecular complexity in modern drug candidates. Continuous innovation in flow chemistry and automated synthesis platforms further enhances its accessibility, addressing queries like "scalable pyrimidine synthesis" or "continuous processing of heterocycles". This forward-looking perspective ensures its enduring relevance in synthetic chemistry.
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