Cas no 672324-80-0 (5-(Aminomethyl)pyrimidin-2-amine)

5-(Aminomethyl)pyrimidin-2-amine is a versatile heterocyclic compound featuring both aminomethyl and amino functional groups on a pyrimidine scaffold. Its bifunctional structure makes it a valuable intermediate in pharmaceutical and agrochemical synthesis, particularly for the development of nucleoside analogs and enzyme inhibitors. The compound exhibits high reactivity due to the presence of primary amine groups, enabling efficient derivatization for tailored applications. Its pyrimidine core contributes to strong binding affinity in biological systems, enhancing its utility in medicinal chemistry. The compound is typically supplied with high purity, ensuring consistent performance in research and industrial processes. Proper handling under inert conditions is recommended due to its sensitivity to moisture and oxidation.
5-(Aminomethyl)pyrimidin-2-amine structure
672324-80-0 structure
Product Name:5-(Aminomethyl)pyrimidin-2-amine
CAS No:672324-80-0
MF:C5H8N4
MW:124.14381980896
MDL:MFCD10696908
CID:855704
PubChem ID:23569319
Update Time:2025-06-14

5-(Aminomethyl)pyrimidin-2-amine Chemical and Physical Properties

Names and Identifiers

    • 5-(Aminomethyl)pyrimidin-2-amine
    • 5-Pyrimidinemethanamine, 2-amino- (9CI)
    • 2-AMINO-5-AMINOMETHYLPYRIMIDINE
    • 2-AMINO-5-PYRIMIDINEMETHANAMINE
    • 5-pyrimidinemethanamine,2-amino
    • AB58502
    • CS-0045884
    • J-516279
    • XBB32480
    • MFCD10696908
    • SCHEMBL8193956
    • DTXSID50635008
    • AS-41812
    • 672324-80-0
    • 5-pyrimidinemethanamine,2-amino-
    • AKOS006227687
    • MDL： MFCD10696908
    • Inchi： 1S/C5H8N4/c6-1-4-2-8-5(7)9-3-4/h2-3H,1,6H2,(H2,7,8,9)
    • InChI Key： HMWDLVRYRPUQOL-UHFFFAOYSA-N
    • SMILES： N1C(N)=NC=C(C=1)CN

Computed Properties

  • Exact Mass: 124.07500
  • Monoisotopic Mass: 124.074896272g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 4
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 1
  • Complexity: 77
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -1.3
  • Topological Polar Surface Area: 77.8?2

Experimental Properties

  • PSA: 77.82000
  • LogP: 0.79900

5-(Aminomethyl)pyrimidin-2-amine Customs Data

  • HS CODE：2933599090
  • Customs Data：

    China Customs Code:

    2933599090

    Overview:

    2933599090. Other compounds with pyrimidine ring in structure(Including other compounds with piperazine ring on the structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

    Declaration elements:

    Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

    Summary:

    2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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5-(Aminomethyl)pyrimidin-2-amine Suppliers

Amadis Chemical Company Limited
Gold Member
Audited Supplier Audited Supplier
(CAS:672324-80-0)5-(Aminomethyl)pyrimidin-2-amine
Order Number:A1171316
Stock Status:in Stock
Quantity:100mg/250mg/1g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 01:19
Price ($):173.0/314.0/735.0

5-(Aminomethyl)pyrimidin-2-amine Related Literature

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Additional information on 5-(Aminomethyl)pyrimidin-2-amine

Comprehensive Overview of 5-(Aminomethyl)pyrimidin-2-amine (CAS No. 672324-80-0): Properties, Applications, and Industry Insights

The compound 5-(Aminomethyl)pyrimidin-2-amine (CAS No. 672324-80-0) is a specialized pyrimidine derivative with significant potential in pharmaceutical and agrochemical research. Its unique molecular structure, featuring an aminomethyl group at the 5-position and an amine group at the 2-position, makes it a versatile intermediate for synthesizing bioactive molecules. This article explores its properties, synthesis routes, and emerging applications while addressing trending topics like green chemistry and AI-driven drug discovery.

In recent years, the demand for heterocyclic compounds like 5-(Aminomethyl)pyrimidin-2-amine has surged due to their role in developing kinase inhibitors and antiviral agents. Researchers are particularly interested in its potential to modulate protein-protein interactions, a hot topic in cancer therapeutics. The compound’s water solubility and stability under physiological conditions further enhance its appeal for medicinal chemistry applications.

Synthetic routes to CAS No. 672324-80-0 often involve catalytic amination or reductive alkylation of pyrimidine precursors. A 2023 study highlighted an eco-friendly approach using enzyme-mediated catalysis, aligning with the industry’s shift toward sustainable synthesis. Analytical characterization typically employs HPLC-MS and NMR spectroscopy, with purity thresholds exceeding 98% for pharmaceutical-grade material.

Beyond pharmaceuticals, this compound shows promise in crop protection formulations. Its ability to act as a chelating agent for micronutrients addresses the growing need for high-efficiency fertilizers in precision agriculture. Regulatory agencies classify it as non-hazardous under standard handling conditions, though proper PPE is recommended during lab-scale operations.

The market for pyrimidine-based intermediates is projected to grow at 6.2% CAGR through 2030, driven by demand for small-molecule drugs and bioconjugates. Patent analysis reveals increasing filings involving 672324-80-0 for neurological disorder treatments, particularly in NMDA receptor modulation. This aligns with Google Trends data showing rising searches for "neuroprotective compounds" and "blood-brain barrier penetrants".

Quality control protocols for 5-(Aminomethyl)pyrimidin-2-amine emphasize residual solvent monitoring and genotoxic impurity screening, reflecting stricter ICH guidelines. Leading suppliers now provide GMP-certified batches with comprehensive COA documentation, responding to the pharmaceutical industry’s emphasis on supply chain transparency.

Future research directions include exploring its utility in PROTAC technology and RNA-targeting therapeutics – two areas dominating recent scientific literature. The compound’s dual functionalization sites offer unique opportunities for structure-activity relationship studies using machine learning algorithms, a convergence point between chemistry and computational biology.

672324-80-0 (5-(Aminomethyl)pyrimidin-2-amine) Related Products

Recommended suppliers
Amadis Chemical Company Limited
(CAS:672324-80-0)5-(Aminomethyl)pyrimidin-2-amine
A1171316
Purity:99%/99%/99%
Quantity:100mg/250mg/1g
Price ($):173.0/314.0/735.0
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