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• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Aralkylamines
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Amines Aralkylamines

Comprehensive Analysis of (pyrimidin-5-yl)methanamine dihydrochloride (CAS No. 1956356-28-7): Properties, Applications, and Research Insights

(pyrimidin-5-yl)methanamine dihydrochloride (CAS No. 1956356-28-7) is a specialized organic compound gaining traction in pharmaceutical and biochemical research due to its unique structural features. This pyrimidine derivative is characterized by its dihydrochloride salt form, which enhances solubility and stability for experimental applications. Researchers are increasingly exploring its potential as a building block in drug discovery, particularly for kinase inhibitors and epigenetic modulators.

The compound's molecular framework features a pyrimidin-5-yl core linked to a methanamine group, offering versatile reactivity for medicinal chemistry applications. Recent studies highlight its utility in developing small molecule therapeutics targeting metabolic disorders and inflammatory pathways. The dihydrochloride formulation (CAS 1956356-28-7) ensures improved handling characteristics compared to free base forms, addressing common challenges in compound formulation and bioavailability optimization.

In the context of current drug discovery trends, (pyrimidin-5-yl)methanamine dihydrochloride aligns with growing interest in heterocyclic compounds for targeted therapies. Its structural similarity to nucleobases makes it particularly relevant for RNA-targeting drugs – a hot topic in antisense oligonucleotide research. The scientific community has noted its potential in fragment-based drug design, where its moderate molecular weight (MW: ~220 g/mol) offers optimal properties for lead compound development.

From a synthetic chemistry perspective, this compound (CAS 1956356-28-7) serves as a valuable intermediate for constructing more complex pharmacophores. Its amine functionality allows for diverse coupling reactions, while the pyrimidine ring provides hydrogen bonding sites crucial for molecular recognition. Recent publications demonstrate its use in creating allosteric modulators for G-protein coupled receptors (GPCRs), reflecting broader industry focus on signal transduction therapeutics.

Quality control parameters for (pyrimidin-5-yl)methanamine dihydrochloride typically include HPLC purity >98% and rigorous salt stoichiometry verification. Analytical methods such as 1H-NMR and mass spectrometry confirm structural integrity, while XRPD analysis ensures consistent crystalline form – critical considerations for preclinical development. The compound's stability under various pH conditions makes it suitable for formulation screening studies.

Emerging applications in chemical biology leverage this compound's ability to serve as a molecular probe for studying enzyme mechanisms. Its structural motif appears in several clinical candidates for oncology and immunology indications, driving commercial demand for high-quality material (CAS 1956356-28-7). Suppliers now offer custom isotope-labeled versions (13C, 15N) to support ADME studies and metabolic pathway investigations.

The safety profile of (pyrimidin-5-yl)methanamine dihydrochloride has been documented in standard in vitro assays, showing favorable cytotoxicity thresholds for research applications. Proper handling requires standard laboratory precautions, with particular attention to its hygroscopic nature. Storage recommendations typically specify desiccated conditions at 2-8°C to maintain long-term stability of this research chemical.

Looking ahead, the pharmaceutical industry's growing emphasis on precision medicine suggests expanding roles for pyrimidine-based compounds like this dihydrochloride salt. Ongoing research explores its incorporation into PROTAC molecules and other targeted protein degradation systems. The compound's commercial availability through major chemical suppliers ensures accessibility for academic and industrial researchers pursuing innovative therapeutic strategies.

• 25198-95-2(pyrimidin-5-ylmethanamine)
• 14273-46-2((2-Methylpyrimidin-5-yl)methanamine)
• 179323-61-6(1-pyrimidin-5-ylethanamine)
• 1234616-20-6(5-(Hydrazinylmethyl)pyrimidine Hydrochloride)
• 933685-83-7((2-Chloropyrimidin-5-yl)methanamine)
• 66007-71-4((1S)-1-pyrimidin-5-ylethanamine)
• 497818-07-2(methyl(pyrimidin-5-ylmethyl)amine)
• 2036-41-1(5-Methylpyrimidine)
• 672324-80-0(5-(Aminomethyl)pyrimidin-2-amine)
• 179601-39-9((1R)-1-pyrimidin-5-ylethanamine)