• 1. Synthesis and in vitro evaluation of donepezil-based reactivators and analogues for nerve agent-inhibited human acetylcholinesterase
  Julien Renou,José Dias,Guillaume Mercey,Tristan Verdelet,Catherine Rousseau,Anne-Julie Gastellier,Mélanie Arboléas,Mélanie Touvrey-Loiodice,Rachid Baati,Ludovic Jean,Florian Nachon,Pierre-Yves Renard RSC Adv. 2016 6 17929

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Comprehensive Overview of 3-hydroxy-6-methylpyridine-2-carbaldehyde (CAS No. 66497-42-5): Properties, Applications, and Innovations

3-hydroxy-6-methylpyridine-2-carbaldehyde (CAS No. 66497-42-5) is a versatile organic compound with a pyridine backbone, widely recognized for its unique chemical properties and broad applicability in pharmaceuticals, agrochemicals, and material science. This heterocyclic aldehyde features a hydroxyl group at the 3-position and a methyl group at the 6-position, making it a valuable intermediate in synthetic chemistry. Its molecular formula, C₇H₇NO₂, and structural specificity have garnered significant attention from researchers exploring bioactive molecules and catalysis.

In recent years, the demand for 3-hydroxy-6-methylpyridine-2-carbaldehyde has surged due to its role in developing antioxidant agents and metal-chelating ligands. A growing trend in green chemistry has further highlighted its potential as a sustainable building block for biodegradable materials. Users frequently search for its synthesis methods, solubility data, and safety profiles, reflecting its relevance in both academic and industrial settings. Notably, its CAS No. 66497-42-5 serves as a critical identifier in regulatory and procurement databases.

The compound’s pharmaceutical applications are particularly noteworthy. Studies suggest its derivatives exhibit neuroprotective effects, aligning with the rising interest in neurodegenerative disease research. Additionally, its chelating properties are exploited in designing fluorescence probes for environmental monitoring, a hot topic in pollution detection. Researchers also explore its use in coordination polymers, addressing queries about advanced material design.

From a commercial perspective, 3-hydroxy-6-methylpyridine-2-carbaldehyde is often discussed alongside cost-effective synthesis routes and scalability challenges. Manufacturers emphasize its high purity grades (>98%) to meet the stringent requirements of drug formulation and catalysis. Analytical techniques like HPLC and NMR spectroscopy are routinely employed to verify its quality, a detail frequently sought by quality control professionals.

Innovations in catalytic oxidation have further expanded its utility. For instance, its incorporation into asymmetric synthesis protocols addresses the demand for chiral intermediates in API production. Environmental scientists also investigate its degradation pathways, responding to public concerns about chemical persistence in ecosystems. These interdisciplinary applications underscore its adaptability to emerging technologies.

In summary, 3-hydroxy-6-methylpyridine-2-carbaldehyde (CAS No. 66497-42-5) stands at the intersection of synthetic chemistry, pharmaceutical innovation, and environmental science. Its multifaceted roles and evolving applications make it a compound of enduring significance, poised to address future challenges in healthcare and sustainable industry.

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• 518306-10-0(3-Hydroxy-2-methyl-4-pyridinecarboxaldehyde)
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