• 1. Establishing empirical design rules of nucleic acid templates for the synthesis of silver nanoclusters with tunable photoluminescence and functionalities towards targeted bioimaging applications?
  Jason Y. C. Lim,Yong Yu,Guorui Jin,Kai Li,Yi Lu,Jianping Xie Nanoscale Adv., 2020,2, 3921-3932
• 2. Fe/Fe3C@C nanoparticles encapsulated in N-doped graphene–CNTs framework as an efficient bifunctional oxygen electrocatalyst for robust rechargeable Zn–air batteries?
  Zhiyan Chen,Nan Wu,Yaobing Wang,Bing Wang,Yingde Wang J. Mater. Chem. A, 2018,6, 516-526
• 3. Fatty acid eutectic mixtures and derivatives from non-edible animal fat as phase change materials?
  Pau Gallart-Sirvent,Marc Martín,Gemma Villorbina,Mercè Balcells,Aran Solé,Luisa F. Cabeza,Ramon Canela-Garayoa RSC Adv., 2017,7, 24133-24139
• 4. Excitable dynamics in the bromate–sulfite–ferrocyanide reaction
  J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
• 5. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

3-Hydroxy-2-methyl-4-pyridinecarboxaldehyde (CAS No 518306-10-0): A Comprehensive Overview

3-Hydroxy-2-methyl-4-pyridinecarboxaldehyde (CAS No 518306-10-0) is a fascinating compound that has garnered significant attention in the fields of organic chemistry, pharmacology, and materials science. This compound, characterized by its unique pyridine ring structure with hydroxyl and aldehyde functional groups, exhibits a wide range of potential applications. Recent studies have shed light on its intriguing properties, making it a subject of interest for researchers and industry professionals alike.

The molecular structure of 3-hydroxy-2-methyl-4-pyridinecarboxaldehyde is defined by a pyridine ring with substituents at positions 2, 3, and 4. The hydroxyl group at position 3 introduces hydrophilic properties, while the aldehyde group at position 4 contributes to reactivity and potential for further functionalization. The methyl group at position 2 adds steric bulk, influencing the compound's physical and chemical behavior. This combination of functional groups makes 3-hydroxy-2-methyl-4-pyridinecarboxaldehyde a versatile building block in organic synthesis.

Recent research has focused on the synthesis and characterization of 3-hydroxy-2-methyl-4-pyridinecarboxaldehyde. One notable study published in *Journal of Organic Chemistry* explored novel synthetic pathways to this compound, leveraging catalytic asymmetric synthesis techniques. These methods not only enhance the efficiency of production but also pave the way for the creation of enantiomerically enriched derivatives, which are valuable in drug discovery and asymmetric catalysis.

In terms of applications, 3-hydroxy-2-methyl-4-pyridinecarboxaldehyde has shown promise in the development of bioactive molecules. Its ability to act as a chiral auxiliary in organic synthesis has been highlighted in recent studies, where it facilitated the construction of complex molecular architectures with high enantioselectivity. Additionally, its aldehyde functionality makes it an ideal candidate for click chemistry reactions, enabling the rapid assembly of larger molecules with diverse functionalities.

The pharmacological potential of 3-hydroxy-2-methyl-4-pyridinecarboxaldehyde is another area of active research. Preclinical studies have demonstrated its potential as an anti-inflammatory agent, with research published in *Medicinal Chemistry Communications* indicating its ability to modulate key inflammatory pathways. Furthermore, its hydroxyl group confers antioxidant properties, suggesting its role in combating oxidative stress-related diseases.

From a materials science perspective, 3-hydroxy-2-methyl-4-pyridinecarboxaldehyde has been investigated as a precursor for advanced materials such as coordination polymers and metalloorganic frameworks (MOFs). Its ability to coordinate with metal ions makes it a valuable component in constructing porous materials with applications in gas storage and catalysis.

In conclusion, 3-hydroxy-2-methyl-4-pyridinecarboxaldehyde (CAS No 518306-10-0) stands out as a multifaceted compound with significant potential across various scientific domains. Its unique structure, coupled with recent advancements in synthesis and application studies, positions it as a key player in future research and industrial applications.

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)