Cas no 31191-08-9 (5-hydroxypyridine-2-carbaldehyde)

5-Hydroxypyridine-2-carbaldehyde is a versatile heterocyclic compound featuring both aldehyde and hydroxyl functional groups on a pyridine scaffold. Its unique structure makes it a valuable intermediate in organic synthesis, particularly for constructing pharmacologically active molecules, ligands, and functional materials. The aldehyde group offers reactivity for condensation and nucleophilic addition reactions, while the hydroxyl group enables further derivatization or coordination chemistry. This compound is often employed in the development of metal-chelating agents, catalysts, and bioactive compounds due to its ability to form stable complexes. Its well-defined reactivity profile and compatibility with diverse synthetic conditions enhance its utility in fine chemical and pharmaceutical research applications.

5-hydroxypyridine-2-carbaldehyde structure

31191-08-9 structure

Product Name:5-hydroxypyridine-2-carbaldehyde

CAS No:31191-08-9

MF:C₆H₅NO₂

MW:123.109401464462

MDL:MFCD10697538

CID:94367

Update Time:2025-05-21

5-hydroxypyridine-2-carbaldehyde Chemical and Physical Properties

Names and Identifiers

- 5-Hydroxypicolinaldehyde
- 2-ForMyl-5-hydroxypyridine
- 5-hydroxypyridine-2-carbaldehyde
- 5-Hydroxypyridine-2-carboxaldehyde
- 5-(hydroxy)picoline aldehyde
- 5-Hydroxy-2-pyridincarbaldehyd
- 5-hydroxy-2-pyridinecarboxaldehyde
- 5-hydroxy-pyridine-2-carbaldehyde
- Picolinaldehyde,dimer
- 6-Formyl-3-pyridinol
- NSC 127948
- NSC 129151
- MDL： MFCD10697538
- Inchi： 1S/C6H5NO2/c8-4-5-1-2-6(9)3-7-5/h1-4,9H
- InChI Key： HSODMUBHOXGNNQ-UHFFFAOYSA-N
- SMILES： OC1=CN=C(C=O)C=C1

Computed Properties

Exact Mass: 123.03200
Hydrogen Bond Donor Count: 1
Hydrogen Bond Acceptor Count: 3
Heavy Atom Count: 9
Rotatable Bond Count: 1

Experimental Properties

Density: 1.327±0.06 g/cm3 (20 oC 760 Torr),
Boiling Point: 363.5℃ at 760 mmHg
Solubility: Dissolution (44 g/l) (25 o C),
PSA: 50.19000
LogP: 0.59970

5-hydroxypyridine-2-carbaldehyde Customs Data

HS CODE：2933399090
Customs Data：

China Customs Code:
2933399090

Overview:

2933399090. Other compounds with non fused pyridine rings in structure. VAT:17.0%. Tax refund rate:13.0%. Regulatory conditions:nothing. MFN tariff:6.5%. general tariff:20.0%

Declaration elements:

Product Name, component content, use to, Please indicate the appearance of Urotropine, 6- caprolactam please indicate the appearance, Signing date

Summary:

2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

5-hydroxypyridine-2-carbaldehyde Pricemore >>

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5-hydroxypyridine-2-carbaldehyde Suppliers

Amadis Chemical Company Limited

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(CAS:31191-08-9)5-hydroxypyridine-2-carbaldehyde

Order Number:A5654

Stock Status:in Stock

Quantity:25g/100g

Purity:99%

Pricing Information Last Updated:Monday, 2 September 2024 16:04

Price ($):162.0/645.0

Email:[email protected]

Product Official Link

5-hydroxypyridine-2-carbaldehyde Related Literature

1. Selectivity of a thiosemicarbazonatocopper(ii) complex towards duplex RNA. Relevant noncovalent interactions both in solid state and solution

Rubén Gil-García,María Ugalde,Natalia Busto,Héctor J. Lozano,José M. Leal,Bego?a Pérez,Gotzon Madariaga,Maite Insausti,Luis Lezama,Roberto Sanz,Lidia M. Gómez-Sainz,Bego?a García,Javier García-Tojal Dalton Trans. 2016 45 18704
2. Tailored metal–organic tetrahedral nanocages with aggregation-induced emission for an anti-counterfeiting ink and stimulus-responsive luminescence

Wenxiu Liu,Guoxing Liu,Xinju Zhu,Xin Han,Anting Lu,Shuai Lu,Linlin Shi,Xin-Qi Hao,Mao-Ping Song New J. Chem. 2022 46 8062
3. Optically pure heterobimetallic helicates from self-assembly and click strategies

Suzanne E. Howson,Guy J. Clarkson,Alan D. Faulkner,Rebecca A. Kaner,Michael J. Whitmore,Peter Scott Dalton Trans. 2013 42 14967
4. Thiosemicarbazones as co-ordinating agents. Solution chemistry and X-ray structure of pyridoxal thiosemicarbazone trihydrate and spectroscopic properties of its metal complexes

M. Ferrari Belicchi,G. Fava Gasparri,E. Leporati,C. Pelizzi,P. Tarasconi,G. Tosi J. Chem. Soc. Dalton Trans. 1986 2455
5. Conformational studies of some potentially bidentate thiosemicarbazones and related complexes of zinc(II)

Carlo Bellitto,Daniela Gattegno,Anna Maria Giuliani,Mario Bossa J. Chem. Soc. Dalton Trans. 1976 758

Related Categories

Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

Additional information on 5-hydroxypyridine-2-carbaldehyde

Comprehensive Overview of 5-Hydroxypyridine-2-carbaldehyde (CAS No. 31191-08-9): Properties, Applications, and Innovations

5-Hydroxypyridine-2-carbaldehyde (CAS No. 31191-08-9) is a versatile organic compound with a molecular formula of C₆H₅NO₂. This heterocyclic aldehyde features a hydroxyl group at the 5-position and a formyl group at the 2-position of the pyridine ring, making it a valuable intermediate in pharmaceutical, agrochemical, and material science research. Its unique structure enables diverse reactivity, including condensation, oxidation, and nucleophilic addition reactions, which are exploited in synthetic chemistry.

In recent years, the demand for 5-hydroxypyridine-2-carbaldehyde derivatives has surged due to their role in developing antioxidant agents, metal-chelating ligands, and bioactive molecules. Researchers are particularly interested in its potential applications in drug discovery, where it serves as a scaffold for designing inhibitors targeting enzymes like kinases and dehydrogenases. Additionally, its fluorescence properties have sparked interest in sensor development for environmental monitoring.

The compound’s synthesis typically involves the oxidation of 5-hydroxypyridine-2-methanol or selective formylation of 5-hydroxypyridine. Advanced techniques such as microwave-assisted synthesis and catalytic oxidation have improved yields and sustainability, aligning with the green chemistry trends. Analytical methods like HPLC, NMR, and mass spectrometry ensure high purity, critical for industrial applications.

From an SEO perspective, users frequently search for "5-hydroxypyridine-2-carbaldehyde uses," "CAS 31191-08-9 suppliers," and "pyridine aldehyde derivatives." Addressing these queries, this compound is commercially available from specialty chemical vendors, often with >98% purity. Its storage requires protection from light and moisture to prevent degradation, a common concern for aldehyde stability.

Emerging studies highlight its utility in nanotechnology, where it functionalizes nanoparticles for catalysis and drug delivery. The hydroxyl-aldehyde synergy also facilitates Schiff base formation, a key step in creating polymers and coordination complexes. Such innovations resonate with trends in smart materials and sustainable manufacturing.

In conclusion, 5-hydroxypyridine-2-carbaldehyde (CAS No. 31191-08-9) exemplifies the intersection of organic synthesis and applied science. Its adaptability across industries underscores its importance, while ongoing research continues to unlock novel applications, from biomedicine to advanced materials.

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