• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Examination of deposit in commercial diluted phosphoric acid
  Analyst, 1880,5, 146-147
• 3. Evolving better nanoparticles: Genetic algorithms for optimising cluster geometries
  Dalton Trans., 2003, 4193-4207
• 4. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
  Manickam Bakthadoss,Tadiparthi Thirupathi Reddy,Vishal Agarwal,Duddu S. Sharada Chem. Commun., 2022,58, 1406-1409

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acid esters
• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzoic acids and derivatives Benzoic acid esters

Comprehensive Overview of Ethyl 4-(phenylamino)benzoate (CAS No. 64878-66-6): Properties, Applications, and Industry Insights

Ethyl 4-(phenylamino)benzoate, identified by its CAS number 64878-66-6, is an organic compound with significant relevance in pharmaceutical and chemical research. This ester derivative, featuring a phenylamino group attached to a benzoate core, exhibits unique physicochemical properties that make it valuable for synthetic applications. Its molecular structure combines aromatic and ester functionalities, enabling versatile reactivity in organic synthesis.

In recent years, the demand for Ethyl 4-(phenylamino)benzoate has grown due to its role as a key intermediate in drug development. Researchers frequently inquire about "synthesis methods for CAS 64878-66-6" or "Ethyl 4-(phenylamino)benzoate solubility," reflecting its importance in optimizing reaction conditions. The compound's melting point (typically 80-85°C) and moderate polarity are critical parameters for purification processes, often discussed in academic forums.

The compound's applications extend to material science, where its UV-absorbing characteristics are leveraged in polymer stabilization. Industry professionals searching for "64878-66-6 in sunscreen formulations" highlight its potential in cosmetic chemistry. Recent studies also explore its antioxidant properties, aligning with the global trend toward sustainable additives. Analytical techniques like HPLC and NMR are essential for quality control, with "Ethyl 4-(phenylamino)benzoate purity analysis" being a common search query among quality assurance specialists.

Environmental considerations are increasingly shaping discussions around CAS 64878-66-6. Regulatory-compliant disposal methods and "biodegradability of phenylamino benzoates" have emerged as hot topics, reflecting the chemical industry's focus on green chemistry principles. The compound's low acute toxicity profile (as per available safety data) makes it preferable for research applications compared to more hazardous alternatives.

From a commercial perspective, suppliers emphasize batch-to-batch consistency and scalable production of Ethyl 4-(phenylamino)benzoate. Market analysts note growing interest in "64878-66-6 price trends" from pharmaceutical procurement teams. The compound's stability under ambient conditions contributes to its logistical advantages, though proper storage in amber glass containers is recommended to prevent photodegradation.

Innovative research directions include exploring CAS 64878-66-6 as a precursor for fluorescent dyes, responding to the nanotechnology sector's demand for novel imaging agents. Patent databases reveal increasing activity around "derivatives of Ethyl 4-(phenylamino)benzoate" for electronic materials, demonstrating its cross-industry potential. Academic publications frequently cite its crystallization behavior, important for formulation scientists optimizing solid dosage forms.

Quality specifications for 64878-66-6 typically require >98% purity, with residual solvent levels being a critical compliance factor. Analytical certificates often include data on heavy metal content and water solubility (approximately 0.1 mg/mL at 25°C), addressing regulatory requirements for pharmaceutical intermediates. The compound's logP value (~3.2) indicates moderate lipophilicity, a property frequently investigated in structure-activity relationship studies.

Emerging applications in agrochemical research have sparked new interest in Ethyl 4-(phenylamino)benzoate, particularly for developing plant growth modifiers. Sustainable production methods using catalytic esterification are gaining attention, with researchers publishing on "green synthesis of 64878-66-6." These developments align with the UN Sustainable Development Goals, making the compound relevant to ESG-focused investors.

Technical literature emphasizes the importance of spectroscopic characterization for CAS 64878-66-6, with IR spectra showing distinctive carbonyl stretching at ~1700 cm?1. The compound's proton NMR pattern (aromatic protons between 6.8-7.8 ppm, ethyl group at ~1.3 and 4.3 ppm) serves as a fingerprint for identity confirmation. These analytical details are crucial for researchers troubleshooting "Ethyl 4-(phenylamino)benzoate spectral interpretation" issues.

Future prospects for 64878-66-6 include potential applications in organic electronics, where its conjugated system may contribute to charge transport properties. The compound's thermal stability (decomposition >200°C) makes it suitable for high-temperature processes, a feature explored in polymer composite research. As analytical techniques advance, studies on its polymorphic forms may uncover new material science applications.

• 104542-38-3(Methyl Ester 3-(Methylamino)benzoic Acid)
• 4629-50-9(Benzoic acid,3-(dimethylamino)-, anhydride with 3-(dimethylamino)benzoic acid)
• 10287-53-3(Ethyl 4-dimethylaminobenzoate)
• 1202-25-1(Methyl 4-(dimethylamino)benzoate)
• 7474-31-9(Benzoic acid,4-(dimethylamino)-, anhydride with 4-(dimethylamino)benzoic acid)
• 18358-63-9(Methyl 4-(methylamino)benzoate)
• 10541-82-9(4-(Methylamino)benzoic Acid Ethyl Ester)
• 5422-63-9(N-Formyl Benzocaine)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)