Cas no 6291-02-7 (4-Chloro-3-methylbenzenesulfonyl chloride)
4-Chloro-3-methylbenzenesulfonyl chloride Chemical and Physical Properties
Names and Identifiers
-
- 4-Chloro-3-methylbenzene-1-sulfonyl chloride
- 4-CHLORO-3-METHYLBENZENESULFONYL CHLORIDE
- Benzenesulfonylchloride, 4-chloro-3-methyl-
- 3-methyl-4-chlorobenzenesulfonyl chloride
- 4-chloro-3-methylbenezenesulfonyl chloride
- 4-chloro-3-methyl-benzenesulfonyl chloride
- 6-chloro-toluene-3-sulfonyl chloride
- 6-Chlor-toluol-3-sulfonylchlorid
- NSC 4610
- BENZENESULFONYL CHLORIDE, 4-CHLORO-3-METHYL-
- NSC4610
- WEPYREBDJIVOHD-UHFFFAOYSA-N
- SBB082001
- RP09045
- PB20117
- chloro(4-chloro-3-methylphenyl)sulfone
- 4-chlor
- 4-chloro-3-methylbenzenesulfonyl chloride, AldrichCPR
- DTXSID70277883
- EN300-141128
- 4-Chloro-3-methylbenzene-1-sulfonylchloride
- 6291-02-7
- J-515019
- NSC-4610
- SCHEMBL305764
- Benzenesulfonylchloride,4-chloro-3-methyl-
- ALBB-016783
- AKOS005139197
- AS-33396
- CS-0050925
- MFCD04117295
- 4-Chloro-3-methylbenzenesulfonyl chloride
-
- MDL： MFCD04117295
- Inchi： 1S/C7H6Cl2O2S/c1-5-4-6(12(9,10)11)2-3-7(5)8/h2-4H,1H3
- InChI Key： WEPYREBDJIVOHD-UHFFFAOYSA-N
- SMILES： ClC1C=CC(=CC=1C)S(=O)(=O)Cl
Computed Properties
- Exact Mass: 223.94700
- Monoisotopic Mass: 223.9465560g/mol
- Isotope Atom Count: 0
- Hydrogen Bond Donor Count: 0
- Hydrogen Bond Acceptor Count: 2
- Heavy Atom Count: 12
- Rotatable Bond Count: 1
- Complexity: 245
- Covalently-Bonded Unit Count: 1
- Defined Atom Stereocenter Count: 0
- Undefined Atom Stereocenter Count : 0
- Defined Bond Stereocenter Count: 0
- Undefined Bond Stereocenter Count: 0
- XLogP3: 3.5
- Topological Polar Surface Area: 42.5
Experimental Properties
- Density: 1.458±0.06 g/cm3 (20 oC 760 Torr),
- Solubility: Very slightly soluble (0.23 g/l) (25 o C),
- PSA: 42.52000
- LogP: 3.65670
4-Chloro-3-methylbenzenesulfonyl chloride Customs Data
- HS CODE：2904909090
- Customs Data：
China Customs Code:
2904909090Overview:
2904909090 Sulfonation of other hydrocarbons\nitrification\Nitrosative derivative(Whether halogenated or not). VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:5.5% general tariff:30.0%
Declaration elements:
Product Name, component content, use to
Summary:
HS:2904909090 sulphonated, nitrated or nitrosated derivatives of hydrocarbons, whether or not halogenated VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%
4-Chloro-3-methylbenzenesulfonyl chloride Pricemore >>
| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PB00179-1 G |
4-chloro-3-methylbenzene-1-sulfonyl chloride |
6291-02-7 | 97% | 1g |
￥ 442.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PB00179-5 G |
4-chloro-3-methylbenzene-1-sulfonyl chloride |
6291-02-7 | 97% | 5g |
￥ 1,339.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PB00179-10 G |
4-chloro-3-methylbenzene-1-sulfonyl chloride |
6291-02-7 | 97% | 10g |
￥ 1,920.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PB00179-25 G |
4-chloro-3-methylbenzene-1-sulfonyl chloride |
6291-02-7 | 97% | 25g |
￥ 3,326.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PB00179-50 G |
4-chloro-3-methylbenzene-1-sulfonyl chloride |
6291-02-7 | 97% | 50g |
￥ 5,121.00 | 2021-05-07 | |
| NAN JING YAO SHI KE JI GU FEN Co., Ltd. | PB00179-100 G |
4-chloro-3-methylbenzene-1-sulfonyl chloride |
6291-02-7 | 97% | 100g |
￥ 7,807.00 | 2021-05-07 | |
| Fluorochem | 020662-250mg |
4-Chloro-3-methyl-benzenesulfonyl chloride |
6291-02-7 | 95% | 250mg |
￡35.00 | 2022-03-01 | |
| Fluorochem | 020662-5g |
4-Chloro-3-methyl-benzenesulfonyl chloride |
6291-02-7 | 95% | 5g |
￡246.00 | 2022-03-01 | |
| Fluorochem | 020662-25g |
4-Chloro-3-methyl-benzenesulfonyl chloride |
6291-02-7 | 95% | 25g |
￡736.00 | 2022-03-01 | |
| Alichem | A019089391-5g |
4-Chloro-3-methylbenzene-1-sulfonyl chloride |
6291-02-7 | 95% | 5g |
348.80 USD | 2021-05-31 |
4-Chloro-3-methylbenzenesulfonyl chloride Related Literature
-
Min Kim,Jae-Joon Lee,Tengling Ye,Panagiotis E. Keivanidis,Kilwon Cho J. Mater. Chem. C, 2020,8, 1686-1696
-
Shintaro Takata,Yoshihiro Miura Phys. Chem. Chem. Phys., 2014,16, 24784-24789
-
Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
-
J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
Additional information on 4-Chloro-3-methylbenzenesulfonyl chloride
Recent Advances in the Application of 4-Chloro-3-methylbenzenesulfonyl chloride (CAS: 6291-02-7) in Chemical Biology and Pharmaceutical Research
4-Chloro-3-methylbenzenesulfonyl chloride (CAS: 6291-02-7) is a key intermediate in the synthesis of various sulfonamide derivatives, which are widely used in pharmaceutical and agrochemical industries. Recent studies have highlighted its role in the development of novel therapeutic agents, particularly in the fields of antimicrobial, anticancer, and anti-inflammatory drug discovery. This research briefing aims to provide an overview of the latest advancements involving this compound, focusing on its synthetic applications, biological activities, and potential industrial uses.
In a 2023 study published in the Journal of Medicinal Chemistry, researchers demonstrated the utility of 4-Chloro-3-methylbenzenesulfonyl chloride as a versatile building block for the synthesis of sulfonamide-based kinase inhibitors. The study reported the successful development of a series of compounds with potent inhibitory activity against tyrosine kinases, which are implicated in various cancers. The researchers employed a multi-step synthetic route, where 4-Chloro-3-methylbenzenesulfonyl chloride served as a critical intermediate for introducing the sulfonamide moiety, which was essential for the compounds' binding affinity and selectivity.
Another significant application of this compound was reported in a 2024 Bioorganic & Medicinal Chemistry Letters article, where it was used to synthesize novel antimicrobial agents. The study focused on addressing the growing issue of antibiotic resistance by developing sulfonamide derivatives with enhanced activity against multidrug-resistant bacterial strains. The researchers found that modifications at the sulfonyl chloride group of 4-Chloro-3-methylbenzenesulfonyl chloride allowed for the introduction of various pharmacophores, leading to compounds with broad-spectrum antibacterial properties.
From a chemical biology perspective, recent work has explored the use of 4-Chloro-3-methylbenzenesulfonyl chloride in activity-based protein profiling (ABPP). A 2023 ACS Chemical Biology paper detailed its application in the development of sulfonyl fluoride probes for studying serine hydrolases. The electrophilic nature of the sulfonyl chloride group makes it an excellent candidate for covalent modification of active site residues, providing valuable insights into enzyme function and inhibition.
Industrial applications of 4-Chloro-3-methylbenzenesulfonyl chloride have also seen advancements. A 2024 patent application disclosed an improved, greener synthesis method for this compound, focusing on reduced solvent usage and higher yields. This development is particularly important given the increasing emphasis on sustainable chemistry practices in the pharmaceutical industry.
In conclusion, 4-Chloro-3-methylbenzenesulfonyl chloride (CAS: 6291-02-7) continues to be a valuable compound in chemical and pharmaceutical research. Its versatility as a synthetic intermediate, combined with the biological relevance of sulfonamide derivatives, ensures its ongoing importance in drug discovery and development. Future research directions may include further exploration of its applications in targeted covalent inhibitors and the development of more sustainable production methods.
6291-02-7 (4-Chloro-3-methylbenzenesulfonyl chloride) Related Products
- 64063-38-3(2,6-Dichloro-3-methylbenzene-1-sulfonyl Chloride)
- 80563-86-6(3-chloro-2-methylbenzenesulfonyl chloride)
- 69145-58-0(2,4-Dichloro-3-methylbenzenesulfonyl chloride)
- 8057-62-3(3-Chloro-2-methylbenzenesulfonyl chloride)
- 88-49-3(4-chloro-2,5-dimethylbenzene-1-sulfonyl chloride)
- 42413-03-6(3-chloro-4-methylbenzene-1-sulfonyl chloride)
- 8051-63-6(3-Chloro-2-methylbenzenesulfonyl chloride)
- 28286-86-4(2,4-dichloro-5-methylbenzenesulfonyl chloride)
- 24653-79-0(3,5-Dichloro-4-methylbenzene-1-sulfonyl chloride)
- 56044-25-8(4-Chloro-3-cyanobenzene-1-sulfonyl chloride)
Audited Supplier
Audited Supplier
Audited Supplier
Audited Supplier
Audited Supplier
