• 1. Development of 2-arylbenzo[h]quinolone analogs as selective CYP1B1 inhibitors
  Jinyun Dong,Zengtao Wang,Qingqing Meng,Qijing Zhang,Guang Huang,Jiahua Cui,Shaoshun Li RSC Adv. 2018 8 15009
• 2. Br?nsted acid-promoted synthesis of common heterocycles and related bio-active and functional molecules
  Sudipta Ponra,K. C. Majumdar RSC Adv. 2016 6 37784
• 3. Recent advances in the synthesis of pharmaceutically active 4-quinolone and its analogues: a review
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• 4. 8,8′-(Benzo[c][1,2,5]thiadiazole-4,7-diyl)bis(quinolin-4(1H)-one): a twisted photosensitizer with AIE properties
  Emmanouil Broumidis,Callum M. S. Jones,Maria Koyioni,Andreas Kourtellaris,Gareth O. Lloyd,Jose Marques-Hueso,Panayiotis A. Koutentis,Filipe Vilela RSC Adv. 2021 11 29102
• 5. Diversity oriented synthesis of 6-nitro- and 6-aminoquinolones and their activity as alkaline phosphatase inhibitors
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Hydroquinolones
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Quinolines and derivatives Quinolones and derivatives Hydroquinolones

Quinolin-4-ol: A Comprehensive Overview

Quinolin-4-ol (CAS No. 611-36-9) is a heterocyclic aromatic compound that has garnered significant attention in various fields of chemistry, biology, and pharmacology. This compound, also known as 4-hydroxyquinoline, belongs to the quinoline family of organic compounds and is characterized by its unique structure and versatile applications. In this article, we will delve into the properties, synthesis, applications, and recent advancements in research related to quinolin-4-ol.

The molecular structure of quinolin-4-ol consists of a benzene ring fused with a pyridine ring, with a hydroxyl group (-OH) attached at the 4-position. This structure imparts quinolin-4-ol with unique electronic properties, making it an interesting subject for both theoretical and experimental studies. The compound is sparingly soluble in water but exhibits good solubility in organic solvents such as ethanol and methanol. Its melting point is approximately 175°C, and it is stable under normal conditions, though it may degrade under strong acidic or basic environments.

Quinolin-4-ol has been extensively studied for its potential in pharmaceutical applications. Recent research has highlighted its role as a precursor in the synthesis of various bioactive compounds. For instance, derivatives of quinolin-4-ol have been investigated for their anti-inflammatory, antioxidant, and anticancer properties. One notable study published in the *Journal of Medicinal Chemistry* demonstrated that certain derivatives of quinolin-4-ol exhibited potent inhibitory activity against key enzymes involved in inflammatory pathways, suggesting their potential as therapeutic agents.

In addition to its pharmaceutical applications, quinolin-4-ol has found utility in the field of materials science. Researchers have explored its use as a building block for constructing advanced materials such as coordination polymers and metalloorganic frameworks (MOFs). These materials exhibit exceptional properties, including high surface area and tunable pore sizes, which make them ideal candidates for gas storage and catalytic applications. A study in *Nature Communications* reported that incorporating quinolin-4-ol into MOFs significantly enhanced their stability and adsorption capacity for small gas molecules like CO2.

The synthesis of quinolin-4-ol has also been a focal point of recent investigations. Traditional methods involve the Skraup synthesis or the Hantzsch dihydropyridine synthesis; however, these methods often require harsh reaction conditions and produce low yields. To address these limitations, researchers have developed more efficient and environmentally friendly synthetic routes. For example, a green chemistry approach utilizing microwave-assisted synthesis was reported in *Green Chemistry*, which significantly reduced reaction time while maintaining high yields.

Beyond its direct applications, quinolin-4 ol serves as an important intermediate in the synthesis of other valuable compounds. For instance, it can be converted into quinoline derivatives with diverse functional groups through various chemical transformations such as oxidation, reduction, or substitution reactions. These derivatives find applications in agrochemicals, dyes, and electronic materials.

Recent advancements in computational chemistry have also shed light on the electronic properties of quinolin 4 ol, providing insights into its reactivity and stability. Density functional theory (DFT) calculations have revealed that the hydroxyl group at the 4-position plays a critical role in modulating the electronic distribution within the molecule. This understanding has facilitated the design of novel derivatives with tailored properties for specific applications.

In conclusion, quinoline 4 ol is a multifaceted compound with a wide range of applications across various scientific disciplines. Its unique structure and versatile reactivity make it an invaluable tool for researchers seeking to develop innovative solutions in medicine, materials science, and beyond. As ongoing research continues to uncover new potentials for this compound,the future prospects for quinoline 4 ol remain bright.

• 195386-00-6(5-Quinolinol, silver(1+) salt)
• 580-20-1(7-Hydroxyquinoline)
• 191915-75-0(1,8-Acridinediol (9CI))
• 220976-08-9(7-Quinolinol hydrate)
• 148896-39-3(Bis(10-hydroxybenzo[h]-quinolinato)beryllium)
• 643-62-9(9-Acridinol)
• 578-67-6(5-Hydroxyquinoline)
• 43129-74-4(3,6-Acridinediol)
• 5464-73-3(1-Acridinol)
• 7132-70-9(acridin-3-ol)