• 1. An insight into the hybridization mechanism of hairpin DNA physically immobilized on chemically modified graphenes
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• 2. An investigation of the electrochemical delithiation process of carbon coated α-Fe2O3nanoparticles
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• 3. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
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• 4. An air-stable organometallic polymer containing titanafluorene moieties obtained by the Sonogashira–Hagihara cross-coupling polycondensation?
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• 5. An approach to C–N activation: coupling of arenesulfonyl hydrazides and arenesulfonyl chlorides with tert-amines via a metal-, oxidant- and halogen-free anodic oxidation??
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines Pyrrolidines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyrrolidines

Comprehensive Guide to 2-(Cyclohexylmethyl)pyrrolidine (CAS No. 60601-74-3): Properties, Applications, and Industry Insights

2-(Cyclohexylmethyl)pyrrolidine (CAS No. 60601-74-3) is a specialized organic compound that has garnered significant attention in pharmaceutical and chemical research. This bicyclic amine derivative, featuring a pyrrolidine ring linked to a cyclohexylmethyl group, exhibits unique structural properties that make it valuable for synthetic applications. Its molecular formula C₁₁H₂₁N and moderate lipophilicity contribute to its versatility in drug discovery, particularly in modulating bioavailability and target engagement.

Recent trends in AI-driven drug design have amplified interest in 2-(Cyclohexylmethyl)pyrrolidine as a scaffold for bioactive molecules. Computational chemistry studies highlight its potential as a conformational constraint element in GPCR-targeted compounds, addressing frequent queries like "how to improve metabolic stability in small molecules." The compound's balanced steric profile and hydrogen bonding capacity align with current industry demands for fragment-based drug discovery (FBDD) building blocks.

From a synthetic chemistry perspective, 60601-74-3 serves as a valuable intermediate for constructing N-heterocyclic compounds. Its reactivity patterns enable diverse transformations, including reductive aminations and palladium-catalyzed couplings—topics frequently searched in organic synthesis forums. The cyclohexyl moiety provides controlled stereochemistry, making it relevant for studies on chiral auxiliaries and asymmetric catalysis.

Analytical characterization of 2-(Cyclohexylmethyl)pyrrolidine typically involves GC-MS, ¹H/¹³C NMR, and HPLC methods. Researchers often search for "boiling point of cyclohexyl-substituted amines" (reported ~230°C for this compound) or "solubility in polar aprotic solvents," reflecting practical formulation considerations. The compound's logP value (~2.1) positions it favorably for blood-brain barrier penetration studies—a hot topic in neurological drug development.

In material science applications, the pyrrolidine-cyclohexyl hybrid structure demonstrates potential as a ligand for metal complexes. This addresses growing interest in transition metal catalysis for sustainable chemistry, with search terms like "nitrogen ligands for C-C coupling reactions" gaining traction. The compound's thermal stability (decomposition >300°C) also makes it suitable for high-temperature polymerization processes.

Quality control protocols for CAS 60601-74-3 emphasize purity verification through residual solvent analysis and water content determination—key concerns in current Good Manufacturing Practice (GMP) compliance. Industry professionals frequently inquire about "storage conditions for amine derivatives" (recommended: inert atmosphere, 2-8°C) and "compatibility with common protecting groups," reflecting its handling requirements.

Emerging applications include its use in ionic liquid formulations for battery electrolytes, coinciding with searches for "nitrogen-based electrolyte additives." The compound's low viscosity and thermal resilience meet demands from the energy storage sector, particularly in optimizing lithium-ion conductivity. This interdisciplinary potential makes 2-(Cyclohexylmethyl)pyrrolidine a compound of interest beyond traditional organic synthesis.

Environmental and safety assessments indicate that 60601-74-3 requires standard amine handling precautions, with particular attention to pH-neutral disposal methods—a subject increasingly searched in green chemistry circles. Its biodegradation profile and ecotoxicological data are becoming relevant for sustainability-focused research programs, aligning with global ESG (Environmental, Social, and Governance) trends in chemical development.

• 1193-68-6((3ar,7ar)-Octahydro-1H-indole)
• 1418201-11-2((2R,5R)-2-Cyclohexyl-5-methylpyrrolidine)
• 753416-80-7((3As,7aS)-2,3,3a,4,5,6,7,7a-octahydro-1H-indole)
• 6326-88-1(Dodecahydro-1H-carbazole)
• 367281-02-5(2-Cyclohexylpyrrolidine)
• 752169-56-5((3aR,7aR)-octahydro-1H-indole, cis)
• 723240-05-9(7-Azabicyclo[2.2.1]heptane,2,5-dimethyl-, (1R,2S,4R,5S)-rel-)
• 874292-42-9(7-Azabicyclo[2.2.1]heptane, 2,5-dimethyl-, (1R,2S,4R,5S)-)
• 147731-70-2(1H-Indole, octahydro-, trans-(±)-)
• 60601-64-1(Pyrrolidine, 2-(cyclohexylmethyl)-, hydrochloride)