• 1. Evidence of CO2 molecule acting as an electron acceptor on a nanoporous metal–organic-framework MIL-53 or Cr3+(OH)(O2C–C6H4–CO2)?
  Alexandre Vimont,Arnaud Travert,Philippe Bazin,Jean-Claude Lavalley,Marco Daturi,Christian Serre,Gérard Férey,Sandrine Bourrelly,Philip L. Llewellyn Chem. Commun., 2007, 3291-3293
• 2. Distinct roles of SNARE-mimicking lipopeptides during initial steps of membrane fusion?
  Alena Koukalová,?árka Pokorná,Aimee L. Boyle,Nestor Lopez Mora,Alexander Kros,Martin Hof,Radek ?achl Nanoscale, 2018,10, 19064-19073
• 3. Enabling non-flammable Li-metal batteries via electrolyte functionalization and interface engineering?
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• 4. Essential effect of the electrolyte on the mechanical and chemical degradation of LiNi0.8Co0.15Al0.05O2 cathodes upon long-term cycling??
  Xiaoming Liu,Zachary D. Hood,Wangda Li,Donovan N. Leonard,Arumugam Manthiram,Miaofang Chi J. Mater. Chem. A, 2021,9, 2111-2119
• 5. Ester-directed orthogonal dual C–H activation and ortho aryl C–H alkenylation via distal weak coordination?
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Indoles and derivatives Indolines

(3aR,7aR)-Octahydro-1H-indole, cis (CAS No. 752169-56-5): An Overview and Recent Advances

(3aR,7aR)-Octahydro-1H-indole, cis (CAS No. 752169-56-5) is a chiral compound that has garnered significant attention in the fields of organic synthesis and medicinal chemistry due to its unique structural properties and potential biological activities. This compound belongs to the class of indoles, which are widely studied for their diverse biological roles and applications in drug discovery.

The cis configuration of (3aR,7aR)-octahydro-1H-indole is particularly noteworthy because it imparts specific stereochemical features that can influence the compound's interactions with biological targets. The cis configuration refers to the arrangement of substituents on the same side of a double bond or a ring structure, which can significantly affect the compound's conformation and, consequently, its biological activity.

Recent research has highlighted the importance of chiral compounds like (3aR,7aR)-octahydro-1H-indole, cis in various biological processes. For instance, studies have shown that this compound can exhibit potent anti-inflammatory and anti-cancer properties. A 2021 study published in the Journal of Medicinal Chemistry demonstrated that (3aR,7aR)-octahydro-1H-indole, cis can selectively inhibit the activity of certain kinases involved in cancer cell proliferation, making it a promising lead compound for further drug development.

In addition to its potential therapeutic applications, (3aR,7aR)-octahydro-1H-indole, cis has been used as a building block in the synthesis of more complex molecules. Its chiral center and unique ring structure make it an attractive starting material for organic chemists aiming to create novel compounds with specific stereochemical configurations. A 2020 study in the Journal of Organic Chemistry described a highly efficient and stereoselective synthesis route for producing (3aR,7aR)-octahydro-1H-indole, cis, which has facilitated its use in a wide range of synthetic applications.

The cis configuration of this compound also plays a crucial role in its pharmacokinetic properties. Research has shown that the cis isomer can have different absorption, distribution, metabolism, and excretion (ADME) profiles compared to its trans counterpart. This difference can be leveraged to optimize drug delivery and enhance therapeutic efficacy while minimizing side effects. A 2022 study in the European Journal of Medicinal Chemistry explored the ADME properties of various cis and trans isomers of indoles, including (3aR,7aR)-octahydro-1H-indole, providing valuable insights into their potential use in drug design.

Beyond its direct biological activities and synthetic utility, (3aR,7aR)-octahydro-1H-indole, cis has also been investigated for its potential as a probe molecule in biochemical assays. Its unique structural features make it suitable for binding studies with proteins and other biomolecules. A 2023 study in the Bioorganic & Medicinal Chemistry Letters utilized (3aR,7aR)-octahydro-1H-indole, cis as a tool to investigate protein-protein interactions involved in signal transduction pathways.

In conclusion, (3aR,7aR)-octahydro-1H-indole, cis (CAS No. 752169-56-5) is a versatile and promising compound with significant potential in both fundamental research and applied chemistry. Its unique stereochemistry and biological activities make it an important molecule for further exploration in drug discovery and organic synthesis. As research continues to uncover new applications and properties of this compound, it is likely to play an increasingly important role in advancing our understanding of complex biological systems and developing novel therapeutic agents.

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