Cas no 57946-56-2 (4-Chloro-2-fluoroaniline)

4-Chloro-2-fluoroaniline is a halogenated aniline derivative with the molecular formula C?H?ClFN. This compound serves as a versatile intermediate in organic synthesis, particularly in the production of pharmaceuticals, agrochemicals, and specialty chemicals. The presence of both chloro and fluoro substituents on the aromatic ring enhances its reactivity, enabling selective functionalization in cross-coupling reactions and nucleophilic substitutions. Its stable yet modifiable structure makes it valuable for constructing complex molecular frameworks. The compound is typically handled under controlled conditions due to its potential toxicity and sensitivity to light and moisture. Proper storage and handling are essential to maintain its purity and efficacy in synthetic applications.
4-Chloro-2-fluoroaniline structure
4-Chloro-2-fluoroaniline structure
Product Name:4-Chloro-2-fluoroaniline
CAS No:57946-56-2
MF:C6H5ClFN
MW:145.562003850937
MDL:MFCD00010625
CID:57217
PubChem ID:93898
Update Time:2025-10-22

4-Chloro-2-fluoroaniline Chemical and Physical Properties

Names and Identifiers

    • 4-Chloro-2-fluoroaniline
    • 2-FLUORO-4-CHLOROANILINE
    • 4-Fluoro-2-chloroaniline
    • 2-fluoro-4-chloro-aniline
    • 4-chloro-2-fluoro-aniline
    • 4-chloro-2-fluorobenzenamine
    • 4-Chloro-2-fluoro-phenylamine
    • 4-Chloro-2-fluoroaniline, 98%
    • AKOS000113481
    • SCHEMBL112519
    • NS00053588
    • Z104477618
    • FT-0612036
    • DTXSID00206666
    • A934160
    • 4-chloranyl-2-fluoranyl-aniline
    • CS-W014353
    • A831681
    • 57946-56-2
    • EINECS 261-034-1
    • EN300-20292
    • MFCD00010625
    • AC-3668
    • W-105428
    • PS-8957
    • AM20040764
    • CCG-302537
    • Benzenamine, 4-chloro-2-fluoro-
    • InChI=1/C6H5ClFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H
    • 4chloro-2-fluoroaniline
    • F0001-1510
    • STL169020
    • DB-024143
    • 4-Chloro-2-fluorobenzenamine; 2-Fluoro-4-chloroaniline; 4-Chloro-2-fluorophenylamine;
    • MDL： MFCD00010625
    • Inchi： 1S/C6H5ClFN/c7-4-1-2-6(9)5(8)3-4/h1-3H,9H2
    • InChI Key： CSFDTBRRIBJILD-UHFFFAOYSA-N
    • SMILES： ClC1C=CC(=C(C=1)F)N
    • BRN： 1934804

Computed Properties

  • Exact Mass: 145.00900
  • Monoisotopic Mass: 145.009
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 1
  • Hydrogen Bond Acceptor Count: 1
  • Heavy Atom Count: 9
  • Rotatable Bond Count: 0
  • Complexity: 99.1
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 0
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • Surface Charge: 0
  • Tautomer Count: nothing
  • XLogP3: nothing
  • Topological Polar Surface Area: 26A^2

Experimental Properties

  • Color/Form: Light yellow or brown liquid
  • Density: 1.311?g/mL?at 25?°C(lit.)
  • Melting Point: No data available
  • Boiling Point: 92°C/2.3mmHg
  • Flash Point: Fahrenheit: 210.2 ° f
    Celsius: 99 ° c
  • Refractive Index: n20/D 1.56(lit.)
  • Water Partition Coefficient: Slightly soluble
  • PSA: 26.02000
  • LogP: 2.64250
  • Solubility: water

4-Chloro-2-fluoroaniline Security Information

  • Symbol: GHS07
  • Prompt：warning
  • Signal Word：Warning
  • Hazard Statement： H302,H312,H315,H319,H332,H335
  • Warning Statement： P261,P280,P305+P351+P338
  • Hazardous Material transportation number：2810
  • WGK Germany：3
  • Hazard Category Code： 20/21/22-36/37/38
  • Safety Instruction： S26-S37/39-S36/37/39
  • Hazardous Material Identification： Xn
  • HazardClass：6.1
  • PackingGroup：III
  • Packing Group：III
  • Hazard Level：6.1
  • Safety Term：6.1
  • Packing Group：III
  • Risk Phrases：R20/21/22; R36/37/38
  • Storage Condition：Store at 4°C,-4At ℃Store…Better

4-Chloro-2-fluoroaniline Customs Data

  • HS CODE：2921420090
  • Customs Data：

    China Customs Code:

    2921420090

    Overview:

    2921420090 Other aniline derivatives and their salts. VAT:17.0% Tax refund rate:9.0% Regulatory conditions:nothing MFN tariff:6.5% general tariff:30.0%

    Declaration elements:

    Product Name, component content, use to

    Summary:

    HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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4-Chloro-2-fluoroaniline Production Method

Production Method 1

Reaction Conditions
1.1 Reagents: Trifluoromethanesulfonic acid ,  Fluorine ;  rt
1.2 Reagents: Sodium hydroxide Solvents: Water ;  neutralized, rt
Reference
Electrophilic aromatic fluorination with fluorine: meta-Directed fluorination of anilines
Alric, J. P.; Marquet, B.; Billard, T.; Langlois, B. R., Journal of Fluorine Chemistry, 2005, 126(4), 661-667

4-Chloro-2-fluoroaniline Preparation Products

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Amadis Chemical Company Limited
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(CAS:57946-56-2)4-Chloro-2-fluoroaniline
Order Number:A934160
Stock Status:in Stock
Quantity:500g
Purity:99%
Pricing Information Last Updated:Friday, 30 August 2024 15:13
Price ($):151.0
Suzhou Senfeida Chemical Co., Ltd
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(CAS:57946-56-2)4-Chloro-2-fluoroaniline
Order Number:sfd242
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Quantity:200KG
Purity:99%
Pricing Information Last Updated:Friday, 19 July 2024 14:32
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Quantity:25KG,200KG,1000KG
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Pricing Information Last Updated:Wednesday, 11 December 2024 17:02
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Tiancheng Chemical (Jiangsu) Co., Ltd
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(CAS:57946-56-2)4-Chloro-2-fluoroaniline
Order Number:LE3698;LE2889178
Stock Status:in Stock
Quantity:25KG,200KG,1000KG
Purity:99%
Pricing Information Last Updated:Friday, 20 June 2025 11:44
Price ($):discuss personally

4-Chloro-2-fluoroaniline Related Literature

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Amadis Chemical Company Limited
(CAS:57946-56-2)4-Chloro-2-fluoroaniline
A934160
Purity:99%
Quantity:500g
Price ($):151.0
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Suzhou Senfeida Chemical Co., Ltd
(CAS:57946-56-2)4-Chloro-2-fluoroaniline
sfd242
Purity:99%
Quantity:200KG
Price ($):Inquiry
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