• 1. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782
• 3. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 4. Embedding cyclic nitrone in mesoporous silica particles for EPR spin trapping of superoxide and other radicals?
  Eric Besson,Stéphane Gastaldi,Emily Bloch,Selma Aslan,Hakim Karoui,Olivier Ouari,Micael Hardy Analyst, 2019,144, 4194-4203
• 5. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952

• Solvents and Organic Chemicals Organic Compounds Organosulfur compounds Thioethers Aryl thioethers

Pyridine, 2-[(trifluoromethyl)thio] (CAS No: 57830-49-6)

Pyridine, 2-[(trifluoromethyl)thio], also known as 2-(trifluoromethylthio)pyridine, is a heterocyclic aromatic compound with significant applications in various fields of chemistry and materials science. This compound has garnered attention due to its unique electronic properties and structural versatility, making it a valuable building block in organic synthesis and material engineering.

The molecular structure of Pyridine, 2-[(trifluoromethyl)thio] consists of a pyridine ring substituted with a trifluoromethylthio group at the 2-position. This substitution pattern imparts distinct electronic characteristics to the molecule, including enhanced electron-withdrawing effects due to the trifluoromethyl group and sulfur atom. Recent studies have demonstrated that these properties make the compound highly suitable for applications in drug design, where fine-tuning electronic interactions is crucial for achieving desired pharmacological outcomes.

In terms of synthesis, researchers have developed several efficient routes to prepare Pyridine, 2-[(trifluoromethyl)thio]. One prominent method involves the nucleophilic substitution of a suitable pyridine derivative with a trifluoromethylthiol group. This approach has been optimized to achieve high yields and excellent purity, ensuring that the compound is readily available for further studies and applications.

The electronic properties of Pyridine, 2-[(trifluoromethyl)thio] have been extensively investigated using computational chemistry techniques. These studies reveal that the trifluoromethylthio substituent significantly alters the π-electron density of the pyridine ring, enhancing its reactivity towards electrophilic substitution reactions. This makes the compound an attractive candidate for use in organic electronics, where controlling electron density is essential for device performance.

Recent advancements in materials science have highlighted the potential of Pyridine, 2-[(trifluoromethyl)thio] as a precursor for constructing advanced functional materials. For instance, researchers have successfully incorporated this compound into polymer frameworks to create materials with tailored optical and electronic properties. These materials show promise for applications in light-emitting diodes (LEDs), sensors, and energy storage devices.

In addition to its synthetic and materials-related applications, Pyridine, 2-[(trifluoromethyl)thio] has also been explored in catalysis. Its ability to coordinate with metal centers makes it a potential ligand in transition metal-catalyzed reactions. Recent studies have demonstrated its effectiveness in facilitating cross-coupling reactions under mild conditions, suggesting its utility in sustainable chemical synthesis.

The environmental impact of Pyridine, 2-[(trifluoromethyl)thio] has also been a topic of interest. Researchers have investigated its biodegradation pathways and toxicity profiles to assess its safety for industrial use. Results indicate that while the compound exhibits moderate toxicity towards aquatic organisms, proper handling and disposal protocols can mitigate environmental risks.

In conclusion, Pyridine, 2-[(trifluoromethyl)thio] (CAS No: 57830-49-6) stands out as a versatile and valuable compound in modern chemistry and materials science. Its unique electronic properties, efficient synthesis methods, and diverse applications underscore its importance as a key building block for advancing technological innovations across multiple disciplines.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)