Production Method 1

87081-58-1

81201-97-0

110187-42-3

57-00-1

110-15-6

53-57-6

58-64-0

1310054-16-0

Reaction Conditions

1.1R:Cleland's reagent, R:MgCl2, R:R:R:R:R:R:H2O, R:KOH, R:NH4Cl, C:56-65-5, C:Coenzyme II, C:9001-51-8, C:9001-40-5, C:9073-95-4, C:9023-83-0, C:9015-83-2, C:9026-23-7, C:9012-49-1, C:9024-93-5, C:9029-03-2, C:9030-25-5, C:9024-62-8, C:37278-21-0, C:9013-02-9, C:9029-12-3, C:9001-15-4, C:1927-31-7, S:H2O

Reference

Enzymatic De Novo Pyrimidine Nucleotide Synthesis

By Schultheisz, Heather L. et al, Journal of the American Chemical Society, 2011, 133(2), 297-304

Creatine Raw materials

• Sodium Bicarbonate-13C
• L-Aspartic acid-
• D-Glucose-13C6

Creatine Preparation Products

• Creatine (57-00-1)
• butanedioic acid (110-15-6)
• NADPH (53-57-6)
• Adenosine 5'-Diphosphate (58-64-0)
• Uridine-1',2,2',3',4',5'-13C6 5'-(tetrahydrogen triphosphate) (1310054-16-0)

• 1. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 2. Elusive 2-aminofuran Diels–Alder substrates for a straightforward synthesis of polysubstituted anilines?
  Ana G. Neo,Ana Bornadiego,Jesús Díaz,Stefano Marcaccini,Carlos F. Marcos Org. Biomol. Chem., 2013,11, 6546-6555
• 3. Emerging enantiomeric resolution materials with homochiral nano-fabrications
  Ji-Ping Wei Nanoscale, 2015,7, 11815-11832
• 4. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 5. Emulsifier-free, organotellurium-mediated living radical emulsion polymerization (emulsion TERP) of styrene: poly(dimethylaminoethyl methacrylate) macro-TERP agent?
  Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Alpha amino acids and derivatives

Introduction to Creatine (CAS No. 57-00-1): A Comprehensive Overview

Creatine, a naturally occurring compound with the chemical formula C?H??N?O?, is widely recognized for its significant role in biochemical processes, particularly in energy metabolism. Its CAS No. 57-00-1 identifies it as a unique and well-documented substance, making it a subject of extensive research and application in various fields, including sports nutrition, medicine, and neuroscience.

The primary function of creatine in biological systems is to facilitate the rapid production of ATP (adenosine triphosphate), the energy currency of cells. This process is crucial for short bursts of high-intensity activities, such as weightlifting or sprinting. The compound is predominantly found in muscle cells, where it helps regenerate ATP more quickly, thereby enhancing endurance and performance.

Recent advancements in scientific research have highlighted the multifaceted benefits of creatine beyond its traditional applications. Studies have demonstrated its potential role in neuroprotection and cognitive enhancement. For instance, research published in the journal Neurobiology of Aging suggests that creatine supplementation may help mitigate age-related cognitive decline by improving mitochondrial function in brain cells.

The mechanism behind creatine's neuroprotective effects lies in its ability to enhance cerebral blood flow and oxygenation. Additionally, it acts as an antioxidant, helping to neutralize reactive oxygen species (ROS) that can cause cellular damage. These findings have opened new avenues for exploring creatine's therapeutic potential in conditions such as Alzheimer's disease and Parkinson's disease.

In the realm of sports nutrition, creatine remains one of the most researched and effective supplements for improving athletic performance. The product name: Creatine is synonymous with enhanced strength, power, and recovery. Athletes across various disciplines, from professional bodybuilders to Olympic sprinters, have incorporated creatine into their training regimens to gain a competitive edge.

The efficacy of creatine is supported by a robust body of evidence. A meta-analysis published in the *Journal of the International Society of Sports Nutrition* concluded that creatine supplementation can increase muscle mass by approximately 1-2 kg and improve strength performance by 5-15%. These benefits are attributed to both water retention within muscle cells (cell volumization) and increased protein synthesis.

Moreover, recent studies have begun to explore the effects of creatine on bone health. Research indicates that creatine may stimulate osteoblast activity, leading to increased bone density. This finding is particularly relevant for postmenopausal women and older adults who are at higher risk of osteoporosis.

The versatility of creatine extends to its applications in medicine as well. For patients with certain genetic disorders that affect muscle function, such as Glycogen Storage Disease type V, creatine supplementation has shown promise in improving muscle strength and quality of life. Additionally, it is being investigated for its potential role in mitigating muscle wasting associated with chronic illnesses like cancer and HIV/AIDS.

The administration of creatine is generally safe and well-tolerated when used within recommended dosages. However, individuals with pre-existing kidney conditions should exercise caution and consult healthcare professionals before starting creatine supplementation. It is also advisable to stay adequately hydrated while using creatine, as it can cause mild water retention.

In conclusion, the compound CAS No. 57-00-1, known as Creatine, is a remarkable substance with far-reaching implications across multiple domains. From enhancing athletic performance to potentially treating neurological disorders and improving bone health, its benefits are continually being uncovered through cutting-edge research. As our understanding of its mechanisms deepens, so too will its applications in human health and well-being.

• 15366-32-2(H-Ile-OEt?HCl)
• 17050-09-8(Creatine Hydrochloride)
• 907991-26-8(Glycine, N-(aminoiminomethyl)-, monosodium salt)
• 923060-89-3(Glycine, N-(aminoiminomethyl)-, ion(1-), 2-hydroxy-N,N,N-trimethylethanaminium (1:1))
• 6020-87-7(Creatine monohydrate)
• 15366-29-7(Glycine,N-(aminoiminomethyl)-N-methyl-, ethyl ester)
• 352-97-6(Guanidinoacetic Acid)
• 5657-05-6(Glycine,N-(aminoiminomethyl)-N-ethyl-)
• 923060-82-6(Glycine, N-(aminoiminomethyl)-, acetate (1:1))
• 284664-86-4(Creatine-(methyl-d3) Monohydrate)