Production Method 1

88-03-9

56866-12-7

82-08-6

Reaction Conditions

1.1 Reagents: Boron trifluoride etherate Solvents: Acetic acid ;  3 h, reflux
2.1 Catalysts: Sulfuric acid Solvents: Ethanol ,  Water ;  18 h, rt
2.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt; neutralized

Reference

Efficient synthesis of rottlerin and its two subunits

Li, Yangfeng; et al, Tetrahedron Letters, 2016, 57(17), 1856-1859

Production Method 2

2657-28-5

1812196-97-6

56866-12-7

82-08-6

Reaction Conditions

1.1 Catalysts: Sulfuric acid Solvents: Ethanol ,  Water ;  18 h, rt
1.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt; neutralized

Reference

Efficient synthesis of rottlerin and its two subunits

Li, Yangfeng; et al, Tetrahedron Letters, 2016, 57(17), 1856-1859

Production Method 3

56866-12-7

82-08-6

Reaction Conditions

1.1 Reagents: Tetrabutylammonium fluoride Solvents: Tetrahydrofuran ;  0 °C; 6 h, rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  rt
2.1 Catalysts: Sulfuric acid Solvents: Ethanol ,  Water ;  18 h, rt
2.2 Reagents: Sodium bicarbonate Solvents: Water ;  rt; neutralized

Reference

Efficient synthesis of rottlerin and its two subunits

Li, Yangfeng; et al, Tetrahedron Letters, 2016, 57(17), 1856-1859

Bis-(3-acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-methan Raw materials

• Methylphloroglucinol
• 2',4',6'-trihydroxy-3'-methylacetophenone
• 2-Propen-1-one, 1-(5,7-dihydroxy-2,2-dimethyl-2H-1-benzopyran-8-yl)-3-phenyl-, (2E)-

Bis-(3-acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-methan Preparation Products

• Rottlerin (82-08-6)
• Bis-(3-acetyl-2,4,6-trihydroxy-5-methyl-phenyl)-methan (56866-12-7)

• 1. An approach for correlating the structural and electrical properties of Zr4+-modified SrBi4Ti4O15/SBT ceramic
  Priyambada Nayak,Tanmaya Badapanda,Anil Kumar Singh,Simanchalo Panigrahi RSC Adv., 2017,7, 16319-16331
• 2. An integrated microfluidic 3D tumor system for parallel and high-throughput chemotherapy evaluation?
  Dan Liu,Rui Hu,Zhongchao Huang,Meilin Sun,Kai Han Analyst, 2020,145, 6447-6455
• 3. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 4. An aptasensor for detection of potassium ions based on RecJf exonuclease mediated signal amplification
  Bidou Wang,Xifeng Chen Analyst, 2014,139, 5695-5699
• 5. An integrated digital microfluidic chip for multiplexed proteomic sample preparation and analysis by MALDI-MS?
  Hyejin Moon,Aaron R. Wheeler,Robin L. Garrell,Chang-Jin “CJ” Kim Lab Chip, 2006,6, 1213-1219

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Diphenylmethanes

• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)