• 1. Establishing the accuracy of position-specific carbon isotope analysis of propane by GC-pyrolysis-GC-IRMS
  ChangjieLiu,PengLiu,XiaofengWang,XiaoqiangLi,JuskeHorita
• 2. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
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• 3. Estimates of hydride ion stability in condensed systems: energy of formation and solvation in aqueous and polar-organic solvents
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• 4. Fe/S-Catalyzed synthesis of 2-benzoylbenzoxazoles and 2-quinolylbenzoxazoles via redox condensation of o-nitrophenols with acetophenones and methylquinolines?
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• 5. Emerging 2D hybrid nanomaterials: towards enhanced sensitive and selective conductometric gas sensors at room temperature
  Hanie Hashtroudi,Ian D. R. Mackinnon J. Mater. Chem. C, 2020,8, 13108-13126

Introduction to 3,4-Dichloro-5-nitropyridine (CAS No. 56809-84-8)

3,4-Dichloro-5-nitropyridine, identified by the Chemical Abstracts Service Number (CAS No.) 56809-84-8, is a significant intermediate in the realm of organic synthesis and pharmaceutical development. This compound, characterized by its nitro and chloro substituents on a pyridine core, has garnered attention due to its versatile reactivity and potential applications in the synthesis of bioactive molecules.

The structural motif of 3,4-Dichloro-5-nitropyridine makes it a valuable building block for medicinal chemists. The presence of both electron-withdrawing nitro and electron-donating chloro groups introduces a rich interplay of electronic effects, enabling diverse chemical transformations. These include nucleophilic aromatic substitution, reduction to amino derivatives, and coupling reactions with various organic substrates. Such reactivity has positioned this compound as a key player in the development of novel therapeutic agents.

In recent years, the pharmaceutical industry has seen a surge in interest for heterocyclic compounds, particularly pyridine derivatives, due to their prevalence in biologically active molecules. 3,4-Dichloro-5-nitropyridine fits squarely within this trend, serving as a precursor for numerous pharmacophores. For instance, its transformation into pyridine-based scaffolds has been explored in the design of kinase inhibitors, which are crucial in treating cancers and inflammatory diseases. The nitro group can be selectively reduced to an amine, facilitating further derivatization into more complex structures.

Moreover, the compound’s utility extends beyond pharmaceuticals. In materials science, pyridine derivatives are employed in the synthesis of organic semiconductors and ligands for catalytic systems. The chlorine atoms in 3,4-Dichloro-5-nitropyridine provide handles for further functionalization via cross-coupling reactions such as Suzuki or Buchwald-Hartwig couplings. These reactions enable the introduction of aryl or alkyl groups, expanding the compound’s applicability in polymer chemistry and coordination chemistry.

Recent advancements in synthetic methodologies have further enhanced the appeal of 3,4-Dichloro-5-nitropyridine. For example, transition-metal-catalyzed reactions have enabled more efficient and selective transformations of this intermediate. Such improvements have not only accelerated drug discovery processes but also reduced the environmental impact of synthetic routes by minimizing waste generation.

The safety profile of 3,4-Dichloro-5-nitropyridine is another critical consideration. While it is not classified as a hazardous material under standard regulatory frameworks, proper handling procedures must be followed to ensure worker safety. This includes using appropriate personal protective equipment (PPE) and operating in well-ventilated areas. Storage conditions should also be carefully monitored to prevent degradation or unintended reactions.

In academic research, 3,4-Dichloro-5-nitropyridine has been utilized in studies exploring novel synthetic pathways and mechanistic insights. Its role as a substrate in reaction studies has provided valuable insights into electron transfer processes and reaction selectivity. These studies contribute to the broader understanding of organic chemistry principles and aid in the development of more efficient synthetic strategies.

The commercial availability of 3,4-Dichloro-5-nitropyridine has also been bolstered by advancements in manufacturing processes. Suppliers now offer high-purity grades suitable for sensitive applications such as drug development. This accessibility has democratized access to this important intermediate for academic institutions and industrial researchers alike.

Looking ahead, the future prospects for 3,4-Dichloro-5-nitropyridine appear promising. As drug discovery continues to evolve towards more targeted and personalized therapies, the demand for versatile intermediates like this compound is expected to rise. Innovations in synthetic chemistry will likely unlock new applications for 3,4-Dichloro-5-nitropyridine, further solidifying its role as an indispensable tool in modern chemical research.

• 21427-62-3(2,5-dichloro-3-nitro-pyridine)
• 22353-33-9(3-Chloro-5-nitropyridine)
• 22353-40-8(2,3-Dichloro-5-nitropyridine)
• 13194-60-0(3-chloro-4-nitro-pyridine)
• 4487-56-3(2,4-Dichloro-5-nitropyridine)
• 5975-12-2(2,4-Dichloro-3-nitropyridine)
• 54079-68-4(4-Chloro-3-nitropyridine hydrochloride)
• 13091-23-1(4-Chloro-3-nitropyridine)
• 22353-35-1(3-chloro-5-nitro-pyridin-2-amine)
• 10425-70-4(4-chloro-3,5-dinitropyridine)