• 1. 158. New syntheses of heterocyclic compounds. Part IV. 3-Azaphenthiazines
  V. A. Petrow,E. L. Rewald J. Chem. Soc. 1945 591
• 2. 117. New syntheses of heterocyclic compounds. Part VI. Triazafluorenes and azaphenazines from 4-chloro-3 : 5-dinitropyridine
  V. A. Petrow,J. Saper J. Chem. Soc. 1946 588
• 3. Index of subjects, 1945
  J. Chem. Soc. 1945 937
• 4. The preparation of a nitropyrido[3,4-c]furoxan: 7-nitro[1,2,5]oxadiazolo-[3,4-c]pyridine 3-oxide
  A. S. Bailey,M. W. Heaton,J. I. Murphy J. Chem. Soc. C 1971 1211
• 5. Formula index
  J. Chem. Soc. 1945 954

• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds C-nitro compounds
• Solvents and Organic Chemicals Organic Compounds Organic 1,3-dipolar compounds Allyl-type 1,3-dipolar organic compounds Organic nitro compounds C-nitro compounds

Recent Advances in the Application of 4-Chloro-3,5-dinitropyridine (CAS: 10425-70-4) in Chemical Biology and Pharmaceutical Research

4-Chloro-3,5-dinitropyridine (CAS: 10425-70-4) is a versatile chemical intermediate that has garnered significant attention in recent years due to its potential applications in chemical biology and pharmaceutical research. This heterocyclic compound, characterized by its nitro and chloro functional groups, serves as a key building block in the synthesis of various biologically active molecules. Recent studies have explored its utility in drug discovery, material science, and agrochemical development, highlighting its broad applicability across multiple disciplines.

One of the most notable advancements in the use of 4-chloro-3,5-dinitropyridine is its role in the development of novel kinase inhibitors. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of this compound exhibit potent inhibitory activity against specific tyrosine kinases implicated in cancer progression. The researchers employed a structure-activity relationship (SAR) approach to optimize the compound's efficacy, resulting in lead candidates with improved selectivity and reduced off-target effects. These findings underscore the potential of 4-chloro-3,5-dinitropyridine as a scaffold for targeted cancer therapies.

In addition to its pharmaceutical applications, 4-chloro-3,5-dinitropyridine has been investigated for its utility in material science. A recent publication in ACS Applied Materials & Interfaces reported the incorporation of this compound into polymeric materials to enhance their thermal stability and electronic properties. The study revealed that the nitro groups in 4-chloro-3,5-dinitropyridine facilitate π-stacking interactions, which contribute to the material's improved performance in optoelectronic devices. This research opens new avenues for the development of advanced functional materials with applications in energy storage and conversion.

Another emerging area of research involves the use of 4-chloro-3,5-dinitropyridine as a precursor for the synthesis of agrochemicals. A 2024 study in Pest Management Science highlighted its effectiveness in the design of next-generation herbicides. By modifying the chloro and nitro substituents, researchers developed compounds with enhanced herbicidal activity and reduced environmental toxicity. These innovations address the growing demand for sustainable agricultural solutions and demonstrate the compound's versatility in addressing global challenges.

Despite these promising developments, challenges remain in the large-scale synthesis and application of 4-chloro-3,5-dinitropyridine. Recent efforts have focused on optimizing synthetic routes to improve yield and reduce waste. For instance, a 2023 Green Chemistry article described a catalytic method that minimizes the use of hazardous reagents while maintaining high efficiency. Such advancements are critical for ensuring the sustainable production of this valuable intermediate.

In conclusion, 4-chloro-3,5-dinitropyridine (CAS: 10425-70-4) continues to be a focal point of research in chemical biology and pharmaceutical sciences. Its diverse applications, ranging from drug discovery to material science and agrochemical development, highlight its significance as a multifunctional building block. Ongoing studies aim to further explore its potential and address existing limitations, paving the way for innovative solutions in these fields.

• 39061-97-7(4-Chloro-3-nitroquinoline)
• 22353-33-9(3-Chloro-5-nitropyridine)
• 4487-56-3(2,4-Dichloro-5-nitropyridine)
• 5975-12-2(2,4-Dichloro-3-nitropyridine)
• 54079-68-4(4-Chloro-3-nitropyridine hydrochloride)
• 24484-96-6(4-chloro-5-nitro-pyridin-2-amine)
• 13091-23-1(4-Chloro-3-nitropyridine)
• 71331-02-7(7-Chloro-8-nitroquinoline)
• 2578-45-2(2-Chloro-3,5-dinitropyridine)
• 5330-86-9(Quinoline,4,7-dichloro-8-nitro-)