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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazines Pyrimidines and pyrimidine derivatives Pyrimidinecarboxylic acids and derivatives

Comprehensive Guide to 2-Aminopyrimidine-5-carboxamide (CAS No. 5388-17-0): Properties, Applications, and Innovations

2-Aminopyrimidine-5-carboxamide (CAS No. 5388-17-0) is a heterocyclic organic compound with a pyrimidine backbone, featuring both an amino group and a carboxamide functional group. This unique structure makes it a versatile intermediate in pharmaceutical synthesis, agrochemical development, and material science. Researchers and industries value its role in constructing drug-like molecules, particularly in kinase inhibitors and antiviral agents. Its molecular formula (C₅H₆N₄O) and high purity grades (≥98%) ensure consistent performance in critical applications.

In recent years, the demand for 2-Aminopyrimidine-5-carboxamide has surged due to its relevance in precision medicine and green chemistry. A trending topic in 2024 is its potential in AI-driven drug discovery, where computational models predict its utility in targeting protein-protein interactions. Users frequently search for "2-Aminopyrimidine-5-carboxamide solubility" or "CAS 5388-17-0 suppliers," reflecting practical concerns. The compound’s water solubility (moderate) and thermal stability (up to 200°C) are key technical parameters often queried.

From a synthetic perspective, 5388-17-0 serves as a building block for biologically active scaffolds. For example, it is integral to the synthesis of Janus kinase (JAK) inhibitors, a hot topic in autoimmune disease therapeutics. SEO-optimized queries like "2-Aminopyrimidine-5-carboxamide derivatives" or "CAS 5388-17-0 NMR data" highlight user interest in structural modifications and analytical validation. Advanced techniques such as microwave-assisted synthesis have improved its production efficiency, aligning with sustainable chemistry goals.

The compound’s crystallographic data and H-bonding capacity are frequently studied for co-crystal engineering, a niche yet growing field in drug formulation. Laboratories often seek "2-Aminopyrimidine-5-carboxamide MSDS" or "safety protocols for 5388-17-0," emphasizing the need for compliant handling. Notably, its low toxicity profile (LD₅₀ > 1000 mg/kg) makes it preferable for R&D applications.

Emerging trends link 2-Aminopyrimidine-5-carboxamide to cancer immunotherapy and mRNA vaccine stabilizers, addressing global health priorities. Searches for "5388-17-0 price trends" or "bulk purchase options" indicate commercial interest. Analytical methods like HPLC purity testing and LC-MS characterization are critical for quality assurance, as documented in recent peer-reviewed journals.

In conclusion, 2-Aminopyrimidine-5-carboxamide (CAS No. 5388-17-0) bridges fundamental research and industrial innovation. Its adaptability to high-throughput screening and computational modeling ensures enduring relevance. For researchers, staying updated on its patent landscape and regulatory status is essential to leverage its full potential.

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