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  Thi Thu Tram Nguyen,Thanh Binh Nguyen Org. Biomol. Chem., 2021,19, 6015-6020
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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridinecarboxylic acids and derivatives Pyridinecarboxylic acids
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Recent Advances in the Application of 2-Amino-5-Bromo-Pyridine-3-Carboxylic Acid (CAS: 52833-94-0) in Chemical Biology and Pharmaceutical Research

2-Amino-5-bromo-pyridine-3-carboxylic acid (CAS: 52833-94-0) is a heterocyclic compound that has garnered significant attention in recent years due to its versatile applications in medicinal chemistry and drug discovery. This compound serves as a crucial building block for the synthesis of various pharmacologically active molecules, particularly in the development of kinase inhibitors, antimicrobial agents, and anti-inflammatory drugs. Recent studies have highlighted its potential in addressing unmet medical needs, making it a focal point of contemporary research in the chemical biology and pharmaceutical sectors.

The structural uniqueness of 2-amino-5-bromo-pyridine-3-carboxylic acid lies in its pyridine core, which is substituted with an amino group at the 2-position, a bromine atom at the 5-position, and a carboxylic acid moiety at the 3-position. This arrangement allows for diverse chemical modifications, enabling the creation of novel derivatives with enhanced biological activity and selectivity. Researchers have exploited this scaffold to design compounds targeting specific enzymes and receptors, thereby opening new avenues for therapeutic intervention.

One of the most notable applications of 2-amino-5-bromo-pyridine-3-carboxylic acid is in the development of kinase inhibitors. Kinases play a pivotal role in cellular signaling pathways, and their dysregulation is implicated in various diseases, including cancer and autoimmune disorders. Recent studies have demonstrated that derivatives of this compound exhibit potent inhibitory activity against several kinases, such as JAK2 and EGFR, which are critical targets in oncology. For instance, a 2023 study published in the Journal of Medicinal Chemistry reported the synthesis of a series of 2-amino-5-bromo-pyridine-3-carboxylic acid derivatives that showed nanomolar potency against JAK2, with promising selectivity profiles.

In addition to its role in kinase inhibition, 2-amino-5-bromo-pyridine-3-carboxylic acid has been explored for its antimicrobial properties. The bromine substituent enhances the compound's ability to interact with bacterial enzymes, making it a valuable scaffold for designing new antibiotics. A recent study in Bioorganic & Medicinal Chemistry Letters highlighted the synthesis of novel analogs that exhibited broad-spectrum activity against drug-resistant strains of Staphylococcus aureus and Escherichia coli. These findings underscore the potential of this compound in addressing the growing threat of antimicrobial resistance.

Another emerging area of research involves the use of 2-amino-5-bromo-pyridine-3-carboxylic acid in the development of anti-inflammatory agents. The compound's ability to modulate inflammatory pathways has been investigated in preclinical models of chronic inflammatory diseases. A 2022 study in the European Journal of Medicinal Chemistry demonstrated that certain derivatives of this compound significantly reduced the production of pro-inflammatory cytokines, such as TNF-α and IL-6, in vitro and in vivo. These results suggest that 2-amino-5-bromo-pyridine-3-carboxylic acid could serve as a promising lead for the development of next-generation anti-inflammatory drugs.

The synthetic versatility of 2-amino-5-bromo-pyridine-3-carboxylic acid has also been leveraged in the design of fluorescent probes and imaging agents. Researchers have functionalized this scaffold with fluorophores to create tools for studying biological processes at the molecular level. For example, a recent publication in Chemical Communications described the development of a 2-amino-5-bromo-pyridine-3-carboxylic acid-based probe for the selective detection of reactive oxygen species (ROS) in live cells. This innovation has significant implications for understanding oxidative stress-related diseases and evaluating the efficacy of antioxidant therapies.

Despite these advancements, challenges remain in the optimization of 2-amino-5-bromo-pyridine-3-carboxylic acid derivatives for clinical use. Issues such as pharmacokinetic properties, toxicity, and scalability of synthesis need to be addressed to translate these findings into viable therapeutics. Ongoing research is focused on improving the drug-like characteristics of these compounds through structural modifications and formulation strategies. Collaborative efforts between academia and industry are expected to accelerate the development of 2-amino-5-bromo-pyridine-3-carboxylic acid-based drugs in the coming years.

In conclusion, 2-amino-5-bromo-pyridine-3-carboxylic acid (CAS: 52833-94-0) represents a highly versatile scaffold with broad applications in chemical biology and pharmaceutical research. Its utility in kinase inhibition, antimicrobial activity, anti-inflammatory effects, and molecular imaging underscores its importance as a key building block in drug discovery. As research continues to uncover new possibilities for this compound, it is poised to make significant contributions to the development of innovative therapies for a range of diseases. Future studies should focus on overcoming existing limitations and exploring novel applications to fully realize the potential of this promising molecule.

• 180340-69-6(6-amino-5-bromopyridine-3-carboxylic acid)
• 335031-01-1((2-amino-5-bromopyridin-3-yl)methanol)
• 532440-94-1(2-Amino-5-methylnicotinic acid)
• 5345-47-1(2-aminopyridine-3-carboxylic acid)
• 443956-55-6(2-Amino-5-bromo-3-(hydroxymethyl)pyridine hydrobromide)
• 50735-34-7(methyl 2-amino-5-bromopyridine-3-carboxylate)
• 59414-89-0(3-Pyridinecarboxylicacid, 2-amino-5-bromo-4-methyl-, hydrobromide (1:1))
• 180340-70-9(methyl 6-amino-5-bromo-pyridine-3-carboxylate)
• 206997-15-1(2-amino-5-bromo-pyridine-3-carbaldehyde)
• 52963-33-4(2-Amino-5-bromo-pyridine-3-carboxylic acid hydrobromide)