Production Method 1

18677-43-5

52606-07-2

96246-00-3

Reaction Conditions

1.1 Reagents: N-Bromosuccinimide Solvents: Acetonitrile ;  overnight, reflux

Reference

Azacoumarin and azathiocoumarin derivatives for use in optically active devices and changing the optical properties of the ophthalmic device

, World Intellectual Property Organization, , ,

5-bromo-2,4-dimethoxy-pyridine Raw materials

• 2,4-DimethoxypyridineI

5-bromo-2,4-dimethoxy-pyridine Preparation Products

• 5-bromo-2,4-dimethoxy-pyridine (52606-07-2)
• 3-Bromo-2,4-dimethoxy-pyridine (96246-00-3)

• 1. Fast synthesis of red Li3BaSrLn3(WO4)8:Eu3+ phosphors for white LEDs under near-UV excitation by a microwave-assisted solid state reaction method and photoluminescence studies
  Bo Wei,Zhenyu Liu,Chen Xie,Shu Yang,Wentao Tang,Aiwei Gu,Wing-Tak Wong,Ka-Leung Wong J. Mater. Chem. C, 2015,3, 12322-12327
• 2. Excitation dependent bidirectional electron transfer in phthalocyanine-functionalised MoS2 nanosheets?
  Christopher J. Harrison,Kyle J. Berean,Enrico Della Gaspera,Jian Zhen Ou,Richard B. Kaner,Kourosh Kalantar-zadeh,Torben Daeneke Nanoscale, 2016,8, 16276-16283
• 3. Enantio- & chemo-selective preparation of enantiomerically enriched aliphatic nitro alcohols using Candida parapsilosis ATCC 7330
  Sowmyalakshmi Venkataraman RSC Adv., 2015,5, 73807-73813
• 4. Dissociative dynamics of O2 on Ag(110)?
  Ivor Lon?ari? Phys. Chem. Chem. Phys., 2015,17, 9436-9445
• 5. Fast-pulsing NMR techniques for the detection of weak interactions: successful natural abundance probe of hydrogen bonds in peptides?
  Amandine Altmayer-Henzien,Valérie Declerck,David J. Aitken,Ewen Lescop,Denis Merlet,Jonathan Farjon Org. Biomol. Chem., 2013,11, 7611-7615

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers

5-Bromo-2,4-dimethoxy-pyridine (CAS No. 52606-07-2): A Versatile Building Block in Modern Organic Synthesis

5-Bromo-2,4-dimethoxy-pyridine (CAS No. 52606-07-2) is a highly functionalized pyridine derivative that has gained significant attention in the field of organic chemistry and pharmaceutical research. This compound, characterized by its bromine and methoxy substituents, serves as a critical intermediate in the synthesis of complex molecules. Its unique structural features make it a valuable tool for researchers exploring heterocyclic chemistry, medicinal chemistry, and material science.

The growing interest in 5-bromo-2,4-dimethoxy-pyridine is driven by its applications in the development of drug candidates and agrochemicals. Recent trends in AI-driven drug discovery and green chemistry have further highlighted the importance of such building blocks. Researchers frequently search for terms like "5-bromo-2,4-dimethoxy-pyridine synthesis", "CAS 52606-07-2 applications", and "pyridine derivatives in pharmaceuticals", reflecting the compound's relevance in cutting-edge scientific inquiries.

One of the key advantages of 5-bromo-2,4-dimethoxy-pyridine is its reactivity in cross-coupling reactions, such as Suzuki-Miyaura and Buchwald-Hartwig couplings. These reactions are pivotal in constructing biaryl structures, which are common motifs in kinase inhibitors and antiviral agents. The compound's electron-rich pyridine core also facilitates its use in catalysis and ligand design, making it a versatile scaffold for innovation.

In addition to its pharmaceutical applications, 5-bromo-2,4-dimethoxy-pyridine is explored in material science for the development of organic semiconductors and light-emitting diodes (LEDs). The demand for sustainable materials has led to increased research into pyridine-based compounds, with this derivative offering tunable electronic properties. Searches for "pyridine derivatives in OLEDs" and "CAS 52606-07-2 material applications" underscore its interdisciplinary significance.

From a synthetic perspective, the preparation of 5-bromo-2,4-dimethoxy-pyridine often involves regioselective bromination of dimethoxypyridine precursors. Modern techniques, such as flow chemistry and microwave-assisted synthesis, have improved the efficiency of its production. These advancements align with the broader shift toward sustainable synthesis, a topic frequently queried in academic and industrial settings.

In conclusion, 5-bromo-2,4-dimethoxy-pyridine (CAS No. 52606-07-2) stands as a cornerstone in contemporary chemical research. Its multifaceted applications—from drug development to advanced materials—highlight its enduring value. As the scientific community continues to prioritize innovation and sustainability, this compound will undoubtedly remain a focal point of exploration and discovery.

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