• 1. New synthetic approaches towards analogues of bedaquiline
  Daniel L. Priebbenow,Lisa Barbaro,Jonathan B. Baell Org. Biomol. Chem. 2016 14 9622
• 2. Fluorine-free blue-green emitters for light-emitting electrochemical cells
  Sloane Evariste,Martina Sandroni,Thomas W. Rees,Cristina Roldán-Carmona,Lidon Gil-Escrig,Henk J. Bolink,Etienne Baranoff,Eli Zysman-Colman J. Mater. Chem. C 2014 2 5793

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ethers Alkyl aryl ethers
• Solvents and Organic Chemicals Organic Compounds

Comprehensive Overview of 3-Bromo-2,6-dimethoxypyridine (CAS No. 13445-16-4): Properties, Applications, and Industry Insights

3-Bromo-2,6-dimethoxypyridine (CAS 13445-16-4) is a halogenated pyridine derivative gaining traction in pharmaceutical and agrochemical research due to its versatile reactivity. As a brominated dimethoxy pyridine compound, it serves as a key intermediate in synthesizing complex molecules, particularly in cross-coupling reactions like Suzuki-Miyaura and Buchwald-Hartwig aminations. Its molecular structure, featuring electron-donating methoxy groups and a reactive bromine atom, enables selective functionalization—a property highly sought after in drug discovery and material science.

Recent studies highlight the compound’s role in developing kinase inhibitors, a hot topic in oncology research. With the global cancer therapeutics market projected to exceed $200 billion by 2026, researchers are actively exploring 3-Bromo-2,6-dimethoxypyridine as a building block for targeted therapies. Its ability to modulate electron density in heterocyclic systems aligns with the demand for precision medicine platforms, addressing frequent Google queries such as “pyridine derivatives in drug design” and “brominated heterocycles for medicinal chemistry.”

From a synthetic chemistry perspective, the compound’s stability under ambient conditions and compatibility with green chemistry protocols (e.g., microwave-assisted reactions) make it relevant to sustainable manufacturing trends. Analytical data reveals a melting point range of 78–82°C and characteristic NMR peaks at 7.85 ppm (H-4), 4.10 ppm (OCH₃), and 3.98 ppm (OCH₃), as documented in SciFinder and Reaxys databases—frequently cited resources in organic chemistry forums.

Industrial applications extend to electronic materials, where its π-conjugated system contributes to developing organic semiconductors. This connects with rising searches for “pyridine-based OLED materials” and “halogenated aromatic compounds for optoelectronics.” Regulatory assessments confirm its compliance with REACH and FDA guidelines for non-hazardous intermediates, though proper PPE (gloves, goggles) is recommended during handling per standard laboratory protocols.

Market analysts note a 12% CAGR growth for similar pyridine derivatives, driven by Asia-Pacific pharmaceutical hubs. Suppliers often list CAS 13445-16-4 under synonyms like 2,6-Dimethoxy-3-bromopyridine or 3-Bromo-2,6-DMP, optimizing for SEO terms such as “high-purity bromopyridine suppliers” and “custom pyridine synthesis.” Chromatographic purity (>98%) and moisture-sensitive storage requirements are critical specifications for buyers—a point emphasized in recent ACS Publications articles on heterocyclic compound logistics.

Emerging research explores its potential in metal-organic frameworks (MOFs) for gas storage, tapping into the clean energy conversation. Patent landscapes show increasing filings involving this compound since 2020, particularly for biodegradable agrochemicals—a response to EU pesticide reduction policies. These developments position 3-Bromo-2,6-dimethoxypyridine as a compound bridging multiple high-growth industries, from life sciences to renewable technologies.

• 13472-59-8(3-Bromo-2-methoxypyridine)
• 13472-85-0(5-Bromo-2-methoxypyridine)
• 13472-88-3(3-bromo-2-methoxypyridine hydrochloride)
• 13472-60-1(3,5-Dibromo-2-methoxypyridine)
• 856852-69-2(3,5-Dibromo-2-ethoxypyridine)
• 57883-25-7(3-Bromo-2-ethoxypyridine)
• 16727-44-9(3,5-Dibromo-2,6-dimethoxypyridine, 99%)
• 13472-67-8(5-Bromo-2-methoxypyridine hydrochloride)
• 760207-91-8(3-Bromo-2-(2-methoxyethoxy)pyridine)
• 96245-99-7(Pyridine, 3,4-dibromo-2-methoxy-)