Cas no 51621-57-9 (H-D-LYS(AC)-OH)

H-D-LYS(AC)-OH refers to an N-terminal hydrogen (H-) and C-terminal acetyl amide ((Ac)amide) protected derivative of D,Lysine ((D,Lys)). This specific protected amino acid features an unprotected alpha-amino group suitable for coupling reactions and a protected carboxyl group terminating with an acetyl amide functionality. Its primary advantage lies in serving as an essential building block in solid-phase peptide synthesis (SPPS). The specific D,Lys configuration allows access to peptides incorporating this particular stereoisomer. Furthermore, the acetyl group provides a removable protecting group that can be selectively deprotected under acidic conditions after peptide chain extension, facilitating efficient synthesis workflows within SPPS protocols.
H-D-LYS(AC)-OH structure
H-D-LYS(AC)-OH structure
Product Name:H-D-LYS(AC)-OH
CAS No:51621-57-9
MF:C8H16N2O3
MW:188.224242210388
CID:855725
PubChem ID:6994067
Update Time:2025-06-16

H-D-LYS(AC)-OH Chemical and Physical Properties

Names and Identifiers

    • H-D-LYS(AC)-OH
    • D-LYSINE(AC)-OH
    • NE-ACETYL-D-LYSINE
    • N-epsilon-Acetyl-D-lysine
    • AC1ODUZR
    • AG-F-74967
    • CTK8G1797
    • I14-19514
    • Nepsilon-Acetyl-D-lysine
    • (R)-6-Acetamido-2-aminohexanoic acid
    • D-Lys(Ac)-OH
    • (2R)-2-AMINO-6-ACETAMIDOHEXANOIC ACID
    • N~6~-Acetyl-D-lysine
    • DTXSID70426374
    • MFCD00237141
    • AKOS006274205
    • (R)-6-Acetamido-2-aminohexanoicacid
    • (2R)-6-acetamido-2-azaniumylhexanoate
    • 51621-57-9
    • AS-56573
    • F10914
    • (2R)-6-acetamido-2-aminohexanoic acid
    • SCHEMBL919222
    • N6-acetyl-D-lysine
    • EN300-7360978
    • Inchi: 1S/C8H16N2O3/c1-6(11)10-5-3-2-4-7(9)8(12)13/h7H,2-5,9H2,1H3,(H,10,11)(H,12,13)/t7-/m1/s1
    • InChI Key: DTERQYGMUDWYAZ-SSDOTTSWSA-N
    • SMILES: OC([C@@H](CCCCNC(C)=O)N)=O

Computed Properties

  • Exact Mass: 188.11609238g/mol
  • Monoisotopic Mass: 188.11609238g/mol
  • Isotope Atom Count: 0
  • Hydrogen Bond Donor Count: 3
  • Hydrogen Bond Acceptor Count: 5
  • Heavy Atom Count: 13
  • Rotatable Bond Count: 7
  • Complexity: 182
  • Covalently-Bonded Unit Count: 1
  • Defined Atom Stereocenter Count: 1
  • Undefined Atom Stereocenter Count : 0
  • Defined Bond Stereocenter Count: 0
  • Undefined Bond Stereocenter Count: 0
  • XLogP3: -2.8
  • Topological Polar Surface Area: 92.4?2

Experimental Properties

  • PSA: 92.42000
  • LogP: 0.79590

H-D-LYS(AC)-OH Security Information

  • Storage Condition:Store at 0-5 ° C

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Additional information on H-D-LYS(AC)-OH

Professional Introduction to Compound with CAS No. 51621-57-9 and Product Name: H-D-LYS(AC)-OH

The compound with the CAS number 51621-57-9 and the product name H-D-LYS(AC)-OH represents a significant advancement in the field of pharmaceutical chemistry and biochemistry. This compound, chemically known as N(alpha)-acetyl-L-lysine hydrochloride, is a derivative of lysine, an essential amino acid crucial for various biological processes. Its unique structure and properties make it a valuable tool in both research and therapeutic applications.

The molecular formula of H-D-LYS(AC)-OH is C8H14N2O3·HCl, reflecting its composition of eight carbon atoms, fourteen hydrogen atoms, two nitrogen atoms, three oxygen atoms, and one chlorine atom. This structure imparts specific chemical and biological properties that have garnered interest from scientists worldwide. The presence of an acetyl group at the alpha position of lysine enhances its reactivity and stability, making it particularly useful in peptide synthesis and protein modification.

In recent years, there has been a surge in research focused on the development of novel biomaterials and therapeutic agents derived from amino acids. H-D-LYS(AC)-OH has emerged as a key intermediate in the synthesis of complex peptides and proteins. Its role in facilitating the formation of amide bonds is critical for constructing biologically active molecules. These amide bonds are the backbone of many proteins and peptides, making H-D-LYS(AC)-OH an indispensable component in peptide coupling reactions.

One of the most compelling applications of H-D-LYS(AC)-OH is in the field of drug development. Peptide-based drugs have gained significant traction due to their high specificity and low toxicity compared to traditional small-molecule drugs. The ability to incorporate H-D-LYS(AC)-OH into peptide chains allows researchers to fine-tune the properties of these drugs, such as their solubility, stability, and bioavailability. This flexibility has led to the discovery of new treatments for various diseases, including cancer, inflammation, and infectious disorders.

Recent studies have highlighted the potential of H-D-LYS(AC)-OH in modulating protein-protein interactions. By serving as a building block for custom-designed peptides, this compound enables the creation of molecules that can interfere with pathological signaling pathways. For instance, research has demonstrated its utility in developing peptidomimetics—molecules that mimic the structure and function of natural peptides but with enhanced properties. Such peptidomimetics are being explored as potential therapeutics for conditions like Alzheimer's disease and autoimmune disorders.

The synthesis of H-D-LYS(AC)-OH involves a series of well-established chemical reactions, including acetylation and hydrochlorination. These processes are optimized to ensure high yield and purity, which are critical for pharmaceutical applications. Advanced synthetic techniques, such as solid-phase peptide synthesis (SPPS), have further streamlined the production of complex peptides incorporating H-D-LYS(AC)-OH as an intermediate.

From a biochemical perspective, H-D-LYS(AC)-OH plays a pivotal role in understanding protein structure-function relationships. Its incorporation into peptides allows researchers to study how specific amino acid residues contribute to protein folding, stability, and interactions with other molecules. This knowledge is invaluable for designing proteins with tailored functions, such as enzymes with enhanced catalytic activity or antibodies with improved binding affinity.

The pharmaceutical industry has also recognized the potential of H-D-LYS(AC)-OH in developing diagnostic tools. Peptide-based biomarkers are increasingly used for early detection and monitoring of diseases. By incorporating this compound into diagnostic assays, scientists can develop highly sensitive and specific tests for conditions like diabetes, cancer, and cardiovascular diseases. The ability to detect these biomarkers at early stages significantly improves patient outcomes by enabling timely intervention.

In conclusion, H-D-LYS(AC)-OH, with its CAS number 51621-57-9, represents a cornerstone in modern pharmaceutical chemistry. Its versatility as a peptide building block has opened new avenues in drug development, protein engineering, and disease diagnosis. As research continues to uncover its full potential, this compound is poised to play an even greater role in advancing human health and improving quality of life.

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