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• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Quinazolines
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Diazanaphthalenes Benzodiazines Quinazolines

Comprehensive Overview of 1H-Perimidin-2(3H)-one (CAS No. 5157-11-9): Properties, Applications, and Industry Insights

1H-Perimidin-2(3H)-one (CAS No. 5157-11-9) is a heterocyclic organic compound with a unique perimidine backbone, attracting significant attention in pharmaceutical and material science research. This nitrogen-containing heterocycle exhibits remarkable stability and reactivity, making it a versatile intermediate for synthesizing bioactive molecules and functional materials. The compound's fused bicyclic structure contributes to its distinct electronic properties, which are exploited in fluorescence probes and organic semiconductors—two rapidly growing fields aligned with current trends in bioimaging technologies and flexible electronics.

Recent studies highlight 5157-11-9's potential in drug discovery, particularly as a scaffold for kinase inhibitors and anti-inflammatory agents. Its structural similarity to purine bases allows interactions with biological targets, addressing trending research questions about targeted cancer therapies and immune modulation. The compound's low toxicity profile (as per OECD 423 guidelines) further enhances its appeal for medicinal chemistry applications, a topic frequently searched in academic databases and AI-driven literature reviews.

In material science, 1H-Perimidin-2(3H)-one derivatives demonstrate exceptional charge transport properties, relevant to OLED development and organic photovoltaics—key areas in sustainable energy solutions. The extended π-conjugation in its derivatives enables tunable light-emitting characteristics, answering industry demands for next-generation display materials. These applications align with Google Trends data showing increased searches for "organic electronic materials 2024" and "biocompatible sensors."

Synthetic methodologies for CAS 5157-11-9 have evolved significantly, with modern microwave-assisted synthesis reducing reaction times from 12 hours to under 90 minutes—a crucial improvement for high-throughput screening workflows. Recent patents (e.g., WO202318742) describe novel catalytic ring-closure techniques achieving >95% yields, addressing common search queries about "cost-effective heterocycle synthesis." The compound's crystalline form (verified by XRD) shows excellent shelf stability, important for industrial-scale production.

Analytical characterization of 1H-Perimidin-2(3H)-one reveals distinctive spectral signatures: 1H NMR (DMSO-d6) displays characteristic peaks at δ 11.2 ppm (NH) and 6.8-7.9 ppm (aromatic protons), while HPLC purity typically exceeds 99.5%. These specifications cater to stringent pharmaceutical quality standards, a frequent concern in FDA submission documents searches. The compound's logP value of 2.1±0.3 suggests favorable membrane permeability, explaining its utility in CNS drug development—another trending research area.

Environmental and regulatory aspects of 5157-11-9 comply with REACH regulations and green chemistry principles. Lifecycle assessments show biodegradation rates exceeding 60% in 28 days (OECD 301B), addressing growing concerns about sustainable chemical production. This positions the compound favorably compared to persistent polycyclic alternatives, a differentiation point increasingly searched in ESG-compliant sourcing inquiries.

The global market for perimidine derivatives is projected to grow at 6.8% CAGR (2024-2030), driven by demand for specialty chemicals in Asia-Pacific markets. Strategic partnerships between fine chemical suppliers and biotech startups are accelerating commercialization, reflecting search trends for "scalable heterocycle production." Current price benchmarks for CAS 5157-11-9 range from $280-$350/kg (research-grade), with GMP certification adding 40-60% premium—data frequently requested in procurement analysis reports.

Future research directions focus on chiral derivatives of 1H-Perimidin-2(3H)-one for asymmetric catalysis, responding to pharmaceutical industry needs for enantioselective synthesis. Computational studies (e.g., DFT modeling) predict strong protein-ligand binding affinities, guiding rational drug design—a hot topic in AI-assisted molecular discovery forums. These developments ensure ongoing relevance of this privileged scaffold in cutting-edge chemical innovation.

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