Production Method 1

515-69-5

28973-98-0

26560-14-5

4891-79-6

17627-44-0

17699-05-7

28973-97-9

91050-14-5

3790-78-1

89-49-6

18794-84-8

40716-66-3

502-61-4

28973-99-1

Reaction Conditions

1.1 Solvents: Water ;  60 h, 25 °C

Reference

Bio-inspired surfactants capable of generating plant volatiles

Bhadani, Avinash; Rane, Jayant; Veresmortean, Cristina; Banerjee, Sanjoy; John, George, Soft Matter, 2015, 11(15), 3076-3082

alpha-Bisabolol Preparation Products

• alpha-Bisabolol (515-69-5)
• 1,3,6,10-Dodecatetraene, 3,7,11-trimethyl-, (E,Z)- (28973-98-0)
• (Z,E)-α-Farnesene (26560-14-5)
• Cyclohexene, 1-methyl-4-(5-methyl-1-methylene-4-hexen-1-yl)- (4891-79-6)
• Cyclohexene,4-(1,5-dimethyl-1,4-hexadien-1-yl)-1-methyl- (17627-44-0)
• Bicyclo[3.1.1]hept-2-ene,2,6-dimethyl-6-(4-methyl-3-penten-1-yl)- (17699-05-7)
• (Z)-β-Farnesene (28973-97-9)
• (2Z)-1-(acetyloxy)-3,7-dimethylocta-2,6-dien-1-olate (91050-14-5)
• cis-Nerolidol (3790-78-1)
• Cyclohexanol,5-methyl-2-(1-methylethenyl)-, 1-acetate (89-49-6)
• (E)-β-Farnesene (18794-84-8)
• trans-nerolidol (40716-66-3)
• α-Farnesene (>80%) (502-61-4)
• 1,3,6,10-Dodecatetraene, 3,7,11-trimethyl-, (Z,Z)- (28973-99-1)

• 1. Engineering Yarrowia lipolytica for sustainable production of the chamomile sesquiterpene (?)-α-bisabolol
  Yirong Ma,Wenjuan Li,Jie Mai,Jinpeng Wang,Yongjun Wei,Rodrigo Ledesma-Amaro,Xiao-Jun Ji Green Chem. 2021 23 780
• 2. α-Bisabolol protects against β-adrenergic agonist-induced myocardial infarction in rats by attenuating inflammation, lysosomal dysfunction, NLRP3 inflammasome activation and modulating autophagic flux
  M. F. Nagoor Meeran,Sheikh Azimullah,Farah Laham,Saeed Tariq,Sameer N. Goyal,Ernest Adeghate,Shreesh Ojha Food Funct. 2020 11 965
• 3. Colorimetric, electroanalytical and theoretical evaluation of the antioxidant activity of Syzygium aromaticum L., Origanum vulgare L., Mentha spicata L. and Eremanthus erythropappus M. essential oils, and their major constituents
  Vanuzia Rodrigues Fernandes Ferreira,Rafaela Magalh?es Brand?o,Matheus P. Freitas,Adelir Aparecida Saczk,Fabiana Silva Felix,Josué M. Silla,Maria Luisa Teixeira,Maria das Gra?as Cardoso New J. Chem. 2019 43 7653
• 4. Skin protein-derived peptide-conjugated vesicular nanocargos for selected skin cell targeting and consequent activation
  Jung Hyeon Cho,Jeong Yi Kang,Seulgi Kim,Hwi Ra Baek,Junoh Kim,Kwang-Suk Jang,Jin Woong Kim J. Mater. Chem. B 2021 9 4956
• 5. Discovery and characterization of a novel sub-group of UbiA-type terpene cyclases with a distinct motif I
  Pan Luo,Jian-Ming Lv,Yan-Feng Xie,Liang-Yan Xiao,Sheng-Ying Qin,Guo-Dong Chen,Xiao-Zhou Luo,Dan Hu,Hao Gao Org. Chem. Front. 2022 9 3057

• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Sesquiterpenoids Sesquiterpenoids
• Solvents and Organic Chemicals Organic Compounds Lipids and lipid-like molecules Prenol lipids Sesquiterpenoids
• Sesquiterpenoids

The Comprehensive Guide to Alpha-Bisabolol (CAS No. 515-69-5): Properties, Benefits, and Applications

Alpha-Bisabolol (CAS No. 515-69-5), also known as levomenol or (-)-α-bisabolol, is a naturally occurring monocyclic sesquiterpene alcohol. It is widely recognized for its soothing, anti-inflammatory, and skin-repairing properties, making it a highly sought-after ingredient in the cosmetics, skincare, and pharmaceutical industries. Derived primarily from the essential oils of chamomile (Matricaria chamomilla), candeia tree (Eremanthus erythropappus), and other botanical sources, alpha-bisabolol has gained significant attention for its gentle yet effective therapeutic benefits.

One of the key reasons behind the growing popularity of alpha-bisabolol is its compatibility with sensitive skin. Unlike harsh synthetic compounds, this natural ingredient is non-irritating and is often used in formulations targeting rosacea, eczema, and acne-prone skin. Its ability to reduce redness and inflammation aligns perfectly with the current consumer demand for clean beauty and sustainable skincare solutions. Additionally, its pleasant, mild floral aroma enhances its appeal in aromatherapy and perfumery applications.

From a chemical perspective, alpha-bisabolol exhibits remarkable stability and solubility, which makes it an excellent candidate for a variety of formulations, including serums, creams, lotions, and even hair care products. Recent studies have highlighted its potential in wound healing and anti-aging treatments, thanks to its ability to promote collagen synthesis and protect the skin from oxidative stress. These findings have spurred interest among researchers and formulators looking to develop next-generation dermocosmetics.

The market for alpha-bisabolol is expanding rapidly, driven by the increasing consumer preference for plant-based and vegan-friendly ingredients. Brands are actively incorporating this compound into their products to meet the demand for cruelty-free and eco-conscious alternatives. Furthermore, its antimicrobial properties make it a valuable component in natural preservatives, reducing the reliance on synthetic parabens and phenoxyethanol.

In the realm of personal care, alpha-bisabolol is often paired with other bioactive ingredients like hyaluronic acid, niacinamide, and ceramides to enhance its efficacy. Its synergistic effects with these compounds make it a staple in anti-aging and barrier repair formulations. For those seeking natural remedies for skin irritation, products containing alpha-bisabolol are increasingly recommended by dermatologists and skincare experts.

Another emerging application of alpha-bisabolol is in the nutraceutical sector, where its anti-inflammatory and antioxidant properties are being explored for oral supplements targeting gut health and immune support. Preliminary research suggests that it may help modulate inflammatory pathways, making it a promising candidate for functional foods and dietary supplements.

For manufacturers and suppliers, sourcing high-quality alpha-bisabolol is critical to ensuring product efficacy. The compound is available in both natural and synthetic forms, with the natural variant being preferred for its superior bioactivity. As the demand for transparent sourcing and ethical production grows, companies are investing in sustainable extraction methods to meet industry standards.

In conclusion, alpha-bisabolol (CAS No. 515-69-5) stands out as a versatile and beneficial compound with a wide range of applications in cosmetics, skincare, and healthcare. Its natural origin, combined with its proven therapeutic effects, positions it as a key ingredient in the shift toward green chemistry and holistic wellness. Whether you're a formulator, a brand owner, or a consumer, understanding the potential of alpha-bisabolol can help you make informed decisions in today's dynamic market.

• 2438-10-0((+)-Terpinen-4-ol)
• 20126-76-5((-)-Terpinen-4-ol)
• 15352-77-9(b-Bisabolol)
• 203633-12-9(a-Terpineol-d3 (Propyl Methyl-d3))
• 562-74-3(rac Terpinen-4-ol)
• 10482-56-1((-)-α-Terpineol)
• 98-55-5(α-Terpineol)
• 22625-86-1(3-Cyclohexene-1-methanol, α,α,3-trimethyl-, (1R)-)
• 23089-26-1(Levomenol)
• 7785-53-7(3-Cyclohexene-1-methanol,a,a,4-trimethyl-, (1R)-)