• 1. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. Enabling stable MnO2 matrix for aqueous zinc-ion battery cathodes?
  Yiding Jiao,Liqun Kang,Jasper Berry-Gair,Kit McColl,Jianwei Li,Haobo Dong,Hao Jiang,Ryan Wang,Furio Corà,Dan J. L. Brett,Ivan P. Parkin J. Mater. Chem. A, 2020,8, 22075-22082
• 3. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 4. Establishing new scaling relations on two-dimensional MXenes for CO2 electroreduction?
  Albertus D. Handoko,Khoong Hong Khoo,Teck Leong Tan,Hongmei Jin,Zhi Wei Seh J. Mater. Chem. A, 2018,6, 21885-21890
• 5. Exceptional activity of sub-nm Pt clusters on CdS for photocatalytic hydrogen production: a combined experimental and first-principles study?
  Qiyuan Wu,Shangmin Xiong,Peichuan Shen,Shen Zhao,Alexander Orlov Catal. Sci. Technol., 2015,5, 2059-2064

Propyl 2,2-Dimethylpropanoate (CAS No. 5129-35-1): An Overview of Its Properties, Applications, and Recent Research

Propyl 2,2-dimethylpropanoate (CAS No. 5129-35-1) is a versatile organic compound that has gained significant attention in various fields, including chemical synthesis, pharmaceuticals, and materials science. This compound is characterized by its unique structure and properties, making it a valuable component in a wide range of applications. In this article, we will delve into the chemical properties, synthesis methods, and recent research developments surrounding propyl 2,2-dimethylpropanoate.

Chemical Structure and Properties

Propyl 2,2-dimethylpropanoate is an ester derived from 2,2-dimethylpropanoic acid and propanol. Its molecular formula is C₈H₁₆O₂, and it has a molecular weight of approximately 144.21 g/mol. The compound features a branched alkyl chain with a tert-butyl group attached to the carboxylic acid moiety, which imparts unique physical and chemical properties. These properties include:

• Solubility: Propyl 2,2-dimethylpropanoate is soluble in most organic solvents but has limited solubility in water.
• Vapor Pressure: The compound has a relatively low vapor pressure at room temperature, making it suitable for applications requiring low volatility.
• Stability: It is stable under normal conditions and does not readily undergo decomposition or degradation.
• Toxicity: While specific toxicity data may vary, propyl 2,2-dimethylpropanoate is generally considered to have low toxicity when handled properly.

Synthesis Methods

The synthesis of propyl 2,2-dimethylpropanoate can be achieved through several methods, each with its own advantages and limitations. One common approach involves the esterification reaction between 2,2-dimethylpropanoic acid and propanol in the presence of an acid catalyst. This reaction can be represented by the following equation:

C6H14O2 + C3H8O → C8H16O2

In recent years, researchers have explored alternative synthetic routes to improve yield and reduce environmental impact. For example, green chemistry approaches using biocatalysts or microwave-assisted synthesis have shown promise in enhancing the efficiency and sustainability of the production process.

Analytical Techniques

The accurate identification and quantification of propyl 2,2-dimethylpropanoate are crucial for quality control and research purposes. Various analytical techniques are employed to achieve this goal:

• Gas Chromatography (GC): GC is a widely used method for the separation and quantification of volatile organic compounds like propyl 2,2-dimethylpropanoate. It provides high sensitivity and resolution.
• Liquid Chromatography (LC):

• Mass Spectrometry (MS): This technique is often coupled with GC or LC to provide detailed structural information about the compound.
• Nuclear Magnetic Resonance (NMR) Spectroscopy: NMR is a powerful tool for confirming the structure of organic compounds by analyzing their nuclear spin interactions.

These analytical methods collectively ensure that the purity and identity of propyl 2,2-dimethylpropanoate are accurately determined.

Applications in Pharmaceuticals and Materials Science

The unique properties of propyl 2,2-dimethylpropanoate make it a valuable component in various applications:

• Pharmaceuticals: The compound can be used as an intermediate in the synthesis of pharmaceuticals due to its stability and reactivity. Recent studies have explored its potential as a precursor for novel drug molecules with improved bioavailability and therapeutic efficacy.
• Materials Science: In materials science, propyl 2,2-dimethylpropanoate is utilized as a solvent or plasticizer in polymer formulations. Its low volatility and high solvency make it suitable for applications requiring stable performance under various conditions.
.

.
.
.
.
.
.
.

• 540-42-1(isobutyl propionate)
• 97-72-3(Isobutyric anhydride)
• 3938-95-2(Ethyl pivalate)
• 1538-75-6(Trimethylacetic anhydride)
• 5129-37-3(Propanoic acid,2,2-dimethyl-, butyl ester)
• 97-85-8(Isobutyl isobutyrate)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)