• 1. Synthesis and photocatalytic H2 evolution properties of four titanium-oxo-clusters based on a cyclohex-3-ene-1-carboxylate ligand
  Mei-Yan Gao,Shumei Chen,Lan-Xia Hu,Lei Zhang,Jian Zhang Dalton Trans. 2017 46 10630
• 2. Application of chemical P-450 model systems to studies on drug metabolism. Part X. Novel hydroxylactonization of γ,δ- and β,γ- unsaturated carboxylic acids with an iron porphyrin–iodosylbenzene system
  Masakatsu Komuro,Tsunehiko Higuchi,Masaaki Hirobe J. Chem. Soc. Perkin Trans. 1 1996 2309
• 3. Amphiphilic allylation of arylidene-1,3-oxazol-5(4H)-one using bis-π-allylpalladium complexes: an approach to synthesis of cyclohexyl and cyclohexenyl α-amino acids
  Afaf R. Genady,Hiroyuki Nakamura Org. Biomol. Chem. 2011 9 7180
• 4. Mutational biosynthesis of a FK506 analogue containing a non-natural starter unit
  Yeon Hee Ban,Jong Hyun Lee,Gyo Rim Gu,Boram Lee,SangJoon Mo,Ho Jeong Kwon,Yeo Joon Yoon Mol. BioSyst. 2013 9 944
• 5. Dimethyl sulfoxide–trimethylsilyl bromide–amine system as a bromonium ion source containing a potential internal nucleophile; unusual bromolactonisation of cyclohex-3-enecarboxylic acid derivatives
  Kazuyuki Miyashita,Akira Tanaka,Hiroaki Mizuno,Masahiro Tanaka,Chuzo Iwata J. Chem. Soc. Perkin Trans. 1 1994 847

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acids
• Solvents and Organic Chemicals Organic Compounds Acids/Esters

Cyclohex-3-ene-1-carboxylic Acid (CAS No. 4771-80-6): A Comprehensive Overview

Cyclohex-3-ene-1-carboxylic acid (CAS No. 4771-80-6) is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, pharmaceutical research, and materials science. This compound, also known as cyclohex-3-enecarboxylic acid, is a monocarboxylic acid with a cyclohexene ring, making it an important intermediate in the synthesis of various bioactive molecules and polymers.

The chemical structure of cyclohex-3-ene-1-carboxylic acid consists of a six-membered ring with a double bond at the 3-position and a carboxylic acid group at the 1-position. This unique structure imparts specific chemical properties that make it valuable in various applications. The compound is typically synthesized through the oxidation of cyclohexene or through the hydrolysis of cyclohexenyl esters.

In recent years, cyclohex-3-ene-1-carboxylic acid has been extensively studied for its potential applications in pharmaceutical research. One notable area of interest is its use as a building block in the synthesis of anti-inflammatory drugs. Research published in the Journal of Medicinal Chemistry has shown that derivatives of cyclohex-3-ene-1-carboxylic acid exhibit potent anti-inflammatory activity, making them promising candidates for the development of new therapeutic agents.

Beyond pharmaceutical applications, cyclohex-3-ene-1-carboxylic acid has also found utility in materials science. Its ability to undergo polymerization reactions makes it an attractive monomer for the synthesis of functional polymers. These polymers have been explored for use in coatings, adhesives, and other industrial applications due to their excellent mechanical properties and chemical stability.

The physical and chemical properties of cyclohex-3-ene-1-carboxylic acid are well-documented. It is a colorless solid with a melting point of approximately 90°C and a boiling point around 250°C at atmospheric pressure. The compound is soluble in common organic solvents such as ethanol, acetone, and dichloromethane but has limited solubility in water. These properties make it easy to handle and process in laboratory and industrial settings.

The reactivity of cyclohex-3-ene-1-carboxylic acid is another key aspect that contributes to its versatility. The presence of both the double bond and the carboxylic acid group allows for a wide range of chemical transformations. For instance, the double bond can undergo addition reactions with hydrogen, halogens, or other nucleophiles, while the carboxylic acid group can participate in esterification, amide formation, and other functional group interconversions.

In terms of safety and handling, cyclohex-3-ene-1-carboxylic acid is generally considered to be stable under normal conditions. However, like many organic compounds, it should be handled with care to avoid exposure to skin or inhalation of vapors. Proper personal protective equipment (PPE) such as gloves and safety goggles should be used when working with this compound.

The environmental impact of cyclohex-3-ene-1-carboxylic acid is also an important consideration. Studies have shown that it has low toxicity to aquatic organisms and does not persist in the environment for extended periods. However, responsible disposal practices should be followed to minimize any potential environmental impact.

In conclusion, cyclohex-3-ene-1-carboxylic acid (CAS No. 4771-80-6) is a valuable compound with diverse applications in pharmaceutical research, materials science, and organic synthesis. Its unique chemical structure and reactivity make it an essential building block for the development of new drugs and functional materials. As research continues to advance, it is likely that new applications for this compound will be discovered, further solidifying its importance in various scientific fields.

• 1338-24-5(Naphthenic acids)
• 15573-40-7((R,R)-rel-Cyclohex-4-ene-1,2-dicarboxylic Acid)
• 10479-42-2(Siglure acid)
• 88-98-2(Tetrahydrophthalic Acid)
• 5708-19-0((1S)-cyclohex-3-ene-1-carboxylic acid)
• 5709-98-8((1R)-cyclohex-3-ene-1-carboxylic acid)
• 92284-35-0(6-METHYLCYCLOHEX-3-ENECARBOXYLIC ACID)
• 2305-26-2(cis-4-Cyclohexene-1,2-dicarboxylic acid)
• 38073-86-8(3-Cyclohexene-1-carboxylic acid, 6-methyl-, cis-)
• 5406-30-4(6-methylcyclohex-3-ene-1-carboxylic Acid)