• 1. Fate of Sb(v) and Sb(iii) species along a gradient of pH and oxygen concentration in the Carnoulès mine waters (Southern France)
  Eléonore Resongles,Corinne Casiot,Fran?oise Elbaz-Poulichet,Rémi Freydier,Odile Bruneel,Christine Piot,Sophie Delpoux,Aurélie Volant,Angélique Desoeuvre Environ. Sci.: Processes Impacts, 2013,15, 1536-1544
• 2. Excited state dynamics of symmetric and asymmetric Cr3(dpa)4Cl2 measured using femtosecond transient absorption spectroscopy?
  Chao-Han Cheng,Wen-Zhen Wang,Shie-Ming Peng,I-Chia Chen Phys. Chem. Chem. Phys., 2017,19, 25471-25477
• 3. Empowering microfluidics by micro-3D printing and solution-based mineral coating?
  Hongxia Li,Aikifa Raza,Qiaoyu Ge,Jin-You Lu,TieJun Zhang Soft Matter, 2020,16, 6841-6849
• 4. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
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• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Carboxylic acids

6-Methylcyclohex-3-ene-1-carboxylic Acid (CAS No. 5406-30-4): Properties, Applications, and Market Insights

6-Methylcyclohex-3-ene-1-carboxylic Acid (CAS No. 5406-30-4) is a specialized organic compound that has garnered significant attention in the fields of pharmaceutical intermediates, flavor and fragrance chemistry, and organic synthesis. This cyclohexene derivative, characterized by a carboxylic acid functional group and a methyl substituent, serves as a versatile building block in various chemical processes. Its molecular formula, C₈H₁₂O₂, and unique structural features make it valuable for researchers and industries alike.

The compound's physical and chemical properties contribute to its wide-ranging applications. With a molecular weight of 140.18 g/mol, 6-Methylcyclohex-3-ene-1-carboxylic Acid typically appears as a colorless to pale yellow liquid at room temperature. Its solubility profile—moderately soluble in organic solvents like ethanol and acetone but sparingly soluble in water—makes it particularly useful in organic synthesis. The presence of both a carboxylic acid group and a double bond in its structure allows for diverse chemical transformations, including esterification, hydrogenation, and Diels-Alder reactions.

In the pharmaceutical industry, 5406-30-4 serves as a key intermediate for the synthesis of more complex molecules. Recent trends in drug discovery have highlighted the importance of such cyclohexene derivatives in developing anti-inflammatory agents and central nervous system (CNS) drugs. The compound's structural motif appears in several bioactive molecules, making it a valuable starting material for medicinal chemistry research. With the growing demand for small molecule therapeutics, the relevance of 6-Methylcyclohex-3-ene-1-carboxylic Acid continues to increase.

The flavor and fragrance industry represents another significant application area for this compound. Its structural similarity to naturally occurring terpenes allows it to serve as a precursor for various aroma chemicals. In particular, derivatives of 6-Methylcyclohex-3-ene-1-carboxylic Acid contribute to woody, citrus, and herbal scent profiles, making them valuable in perfumery and food flavoring. As consumer preferences shift toward natural identical flavors, the demand for such intermediates has seen steady growth.

From a synthetic chemistry perspective, CAS 5406-30-4 offers numerous possibilities. The compound's reactive sites allow for selective modifications, enabling chemists to create diverse molecular architectures. Recent publications have demonstrated its utility in asymmetric synthesis and catalysis, particularly in constructing chiral centers—a crucial aspect of modern pharmaceutical development. The compound's versatility aligns well with current research trends in green chemistry and atom economy.

The market dynamics for 6-Methylcyclohex-3-ene-1-carboxylic Acid reflect its growing importance. Major chemical suppliers have reported increased demand, particularly from contract research organizations (CROs) and specialty chemical manufacturers. Pricing trends indicate moderate stability, with fluctuations primarily tied to raw material availability. The compound's global market shows particular strength in North America and Europe, where pharmaceutical and fragrance industries are well-established.

Quality control and analytical characterization of 5406-30-4 remain critical for end-users. Standard analytical techniques include gas chromatography (GC), high-performance liquid chromatography (HPLC), and nuclear magnetic resonance (NMR) spectroscopy. These methods ensure purity and confirm structural integrity, which are essential for research and industrial applications. Recent advancements in analytical chemistry have enabled more precise quantification of impurities, meeting the stringent requirements of pharmaceutical applications.

Storage and handling recommendations for 6-Methylcyclohex-3-ene-1-carboxylic Acid follow standard practices for carboxylic acids. The compound should be stored in airtight containers under inert atmosphere to prevent oxidation. While not classified as hazardous under normal conditions, proper laboratory safety protocols should always be observed. The compound's stability profile makes it suitable for long-term storage when proper conditions are maintained.

Future prospects for CAS No. 5406-30-4 appear promising, particularly in emerging fields like biocatalysis and sustainable chemistry. Researchers are exploring enzymatic transformations of this compound to create more environmentally friendly synthetic routes. Additionally, its potential in material science, particularly as a monomer for specialty polymers, represents an exciting development area. As industries continue to seek bio-based alternatives to petroleum-derived chemicals, compounds like 6-Methylcyclohex-3-ene-1-carboxylic Acid will likely gain further significance.

For researchers and procurement specialists seeking high purity 6-Methylcyclohex-3-ene-1-carboxylic Acid, several commercial sources exist. Reputable suppliers typically offer the compound in various quantities, from gram-scale for laboratory use to kilogram quantities for industrial applications. Technical data sheets and certificates of analysis (CoA) are generally available upon request, ensuring users can verify quality parameters before purchase.

• 1338-24-5(Naphthenic acids)
• 4771-80-6(cyclohex-3-ene-1-carboxylic acid)
• 15573-40-7((R,R)-rel-Cyclohex-4-ene-1,2-dicarboxylic Acid)
• 130422-89-8(3-Cyclohexene-1-carboxylicacid, 5-methyl-)
• 5708-19-0((1S)-cyclohex-3-ene-1-carboxylic acid)
• 5709-98-8((1R)-cyclohex-3-ene-1-carboxylic acid)
• 15941-50-1(4-Cyclohexene-1,2-dicarboxylic acid, 3-methyl-)
• 2305-26-2(cis-4-Cyclohexene-1,2-dicarboxylic acid)
• 16646-42-7(1-methylcyclohex-3-ene-1-carboxylic acid)
• 16298-46-7(3-Cyclohexene-1-carboxylicacid, 6-formyl-2-methyl-, cis,trans- (8CI))