• 1. Fatty acid positional distribution in colostrum and mature milk of women living in Inner Mongolia, North Jiangsu and Guangxi of China?
  Long Deng,Qian Zou,Biao Liu,Wenhui Ye,Chengfei Zhuo,Li Chen,Ze-Yuan Deng,Ya-Wei Fan,Jing Li Food Funct., 2018,9, 4234-4245
• 2. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339
• 3. Fate of nitrogen-15 in the subsequent growing season of greenhouse tomato plants (Lycopersicon esculentum Mill) as influenced by alternate partial root-zone irrigation
  Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
• 4. Excited-state proton-coupled electron transfer within ion pairs?
  Gerald J. Meyer,Leif Hammarstr?m Chem. Sci., 2020,11, 3460-3473
• 5. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Organonitrogen compounds
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds

Introduction to (Cyclopropylmethyl)sulfamoyl Chloride (CAS No. 454219-12-6)

(Cyclopropylmethyl)sulfamoyl Chloride, identified by the Chemical Abstracts Service Number (CAS No.) 454219-12-6, is a specialized organic compound that has garnered significant attention in the field of pharmaceutical chemistry and medicinal research. This compound belongs to the sulfonamide class, which is well-documented for its diverse biological activities and therapeutic potential. The presence of a cyclopropylmethyl group in its molecular structure imparts unique chemical properties, making it a valuable intermediate in the synthesis of various pharmacologically active agents.

The< strong>cyclopropylmethyl moiety is a key feature of this compound, contributing to its stability and reactivity in synthetic pathways. This structural element has been extensively studied for its ability to enhance the binding affinity and selectivity of drug molecules, particularly in the development of targeted therapies. Recent advancements in computational chemistry have highlighted the role of cyclopropyl groups in optimizing drug-like properties, such as solubility, metabolic stability, and membrane permeability.

In the realm of medicinal chemistry, sulfamoyl chlorides serve as crucial intermediates in the synthesis of sulfonamides, a class of compounds known for their antimicrobial, anti-inflammatory, and anticancer properties. The< strong>sulfamoyl chloride functional group in (Cyclopropylmethyl)sulfamoyl Chloride facilitates the introduction of sulfonamide derivatives into complex molecular frameworks. This reactivity has been leveraged in the design of novel inhibitors targeting enzymes involved in critical biological pathways.

Recent studies have demonstrated the potential of (Cyclopropylmethyl)sulfamoyl Chloride in the development of kinase inhibitors, which are pivotal in treating cancers and inflammatory diseases. The cyclopropylmethyl group's ability to mimic bulky hydrophobic interactions has been found to improve the binding efficiency of these inhibitors to their respective targets. For instance, research published in high-impact journals has shown promising results using derivatives of this compound in preclinical trials for breast cancer and rheumatoid arthritis.

The synthesis of (Cyclopropylmethyl)sulfamoyl Chloride involves multi-step organic reactions that require precise control over reaction conditions to ensure high yield and purity. Advanced synthetic methodologies, including transition metal-catalyzed cross-coupling reactions and palladium-mediated transformations, have been employed to streamline the process. These techniques not only enhance efficiency but also minimize byproduct formation, making the compound more suitable for industrial-scale production.

The pharmacological significance of this compound extends beyond its role as a synthetic intermediate. Preliminary pharmacokinetic studies have indicated that derivatives of (Cyclopropylmethyl)sulfamoyl Chloride exhibit favorable absorption, distribution, metabolism, and excretion (ADME) profiles. This makes them attractive candidates for further development into therapeutic agents with improved bioavailability and reduced toxicity.

In conclusion, (Cyclopropylmethyl)sulfamoyl Chloride (CAS No. 454219-12-6) represents a promising entity in pharmaceutical research due to its unique structural features and versatile applications. The integration of computational modeling with experimental validation has paved the way for innovative drug discovery strategies leveraging this compound. As research continues to uncover new therapeutic targets and mechanisms, compounds like (Cyclopropylmethyl)sulfamoyl Chloride are poised to play a crucial role in addressing unmet medical needs.

• 777952-91-7(N-cyclobutylsulfamoyl chloride)
• 391912-54-2(N-cyclopropylsulfamoyl chloride)
• 10305-43-8(N-butylsulfamoyl Chloride)
• 26118-68-3(Isobutylsulfamoyl Chloride)
• 61758-27-8(Sulfamoyl chloride, hexyl-)
• 61538-06-5(Sulfamoyl chloride, (1-ethylbutyl)-)
• 61517-53-1(Sulfamoyl chloride, (1-propylbutyl)-)
• 668985-04-4(1-BUTANAMINE, N-(CHLOROSULFONYL)-, HYDROCHLORIDE)
• 926207-59-2(N-(cyclopropylmethyl)-N-propylsulfamoyl chloride)
• 10305-42-7(N-propylsulfamoyl Chloride)