• 1. Excitation energies from ground-state density-functionals by means of generator coordinates
  A. B. F. da Silva,K. Capelle Phys. Chem. Chem. Phys., 2009,11, 4564-4569
• 2. Fe(ii)-Assisted one-pot synthesis of ultra-small core–shell Au–Pt nanoparticles as superior catalysts towards the HER and ORR?
  Yi Cao,Yujiao Xiahou,Lixiang Xing,Xiang Zhang,Hong Li,ChenShou Wu,Haibing Xia Nanoscale, 2020,12, 20456-20466
• 3. Enabling shape memory and healable effects in a conjugated polymer by incorporating siloxane via dynamic imine bond?
  Yaling Zhang,Chunhui Dai,Shiwei Zhou,Bin Liu Chem. Commun., 2018,54, 10092-10095
• 4. Emulsion technologies for multicellular tumour spheroid radiation assays?
  Kay S. McMillan,Anthony G. McCluskey,Annette Sorensen,Marie Boyd,Michele Zagnoni Analyst, 2016,141, 100-110
• 5. Dissociation of large gaseous serine clusters produces abundant protonated serine octamer
  Jacob S. Jordan,Evan R. Williams Analyst, 2021,146, 2617-2625

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Organonitrogen compounds
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds

N-propylsulfamoyl Chloride: A Comprehensive Overview

N-propylsulfamoyl chloride, also known by its CAS number 10305-42-7, is a chemical compound that has garnered significant attention in various fields due to its unique properties and versatile applications. This compound, classified under the broader category of sulfamoyl chlorides, is widely used in the synthesis of pharmaceuticals, agrochemicals, and advanced materials. The molecule consists of a sulfonamide group attached to a propyl chain, making it highly reactive and suitable for a range of chemical transformations.

Recent studies have highlighted the potential of N-propylsulfamoyl chloride in the development of novel drug delivery systems. Researchers have explored its ability to act as a bioisostere in medicinal chemistry, where it can replace other functional groups without significantly altering the pharmacokinetic profile of a molecule. This property makes it invaluable in optimizing drug efficacy and reducing side effects. For instance, a 2023 study published in the Journal of Medicinal Chemistry demonstrated that incorporating N-propylsulfamoyl chloride into antiviral compounds enhanced their stability and bioavailability.

In addition to its role in pharmaceuticals, N-propylsulfamoyl chloride has found applications in the synthesis of advanced polymers and coatings. Its reactivity with alcohols and amines allows for the creation of high-performance materials with tailored properties. A notable example is its use in developing water-repellent coatings for textiles and electronics, as reported in a 2023 issue of Advanced Materials. These coatings not only enhance durability but also provide resistance to environmental factors, making them ideal for industrial applications.

The synthesis of N-propylsulfamoyl chloride typically involves the reaction of sulfonamide derivatives with thionyl chloride or phosphorus trichloride. Recent advancements in catalytic methods have improved the efficiency and scalability of this process. For instance, the use of microwave-assisted synthesis has been shown to reduce reaction times by up to 50%, as highlighted in a 2023 paper in Green Chemistry. This development is particularly significant for large-scale production, where time and cost efficiency are critical.

Beyond its chemical applications, N-propylsulfamoyl chloride has also been studied for its environmental impact. Researchers have investigated its biodegradation pathways and toxicity profiles to ensure sustainable practices. A 2023 study published in Environmental Science & Technology revealed that under aerobic conditions, the compound undergoes rapid mineralization, minimizing its ecological footprint. This finding is crucial for industries aiming to adopt greener chemical processes.

In conclusion, N-propylsulfamoyl chloride, with its CAS number 10305-42-7, stands as a pivotal compound in modern chemistry. Its diverse applications, from drug development to material science, coupled with recent advancements in synthesis and environmental compatibility, underscore its importance in both academic research and industrial production. As ongoing studies continue to uncover new potentials, this compound is poised to play an even greater role in shaping future innovations across various sectors.

• 10305-43-8(N-butylsulfamoyl Chloride)
• 10314-35-9(Cyclohexylsulfamoyl Chloride)
• 42065-72-5((3-Chloropropyl)sulfamoyl Chloride)
• 26118-68-3(Isobutylsulfamoyl Chloride)
• 26118-67-2(Isopropylaminosulfonic Acid)
• 61758-27-8(Sulfamoyl chloride, hexyl-)
• 61538-06-5(Sulfamoyl chloride, (1-ethylbutyl)-)
• 61517-53-1(Sulfamoyl chloride, (1-propylbutyl)-)
• 33581-95-2(TERT-BUTYLSULFAMOYL CHLORIDE)
• 16548-07-5(N-Ethylchlorosulfonamide)