• 1. Acetyl group orientation modulates the electronic ground-state asymmetry of the special pair in purple bacterial reaction centers
  P. K. Wawrzyniak,M. T. P. Beerepoot,H. J. M. de Groot,F. Buda Phys. Chem. Chem. Phys., 2011,13, 10270-10279
• 2. An artificial CO-releasing metalloprotein built by histidine-selective metallation?
  Inês S. Albuquerque,Hélia F. Jeremias,Miguel Chaves-Ferreira,Dijana Matak-Vinkovic,Omar Boutureira,Carlos C. Rom?o Chem. Commun., 2015,51, 3993-3996
• 3. An approach towards the synthesis of novel fused nitrogen tricyclic heterocyclic scaffolds via GBB reaction?
  Sandip Gangadhar Balwe,Yeon Tae Jeong Org. Biomol. Chem., 2018,16, 1287-1296
• 4. An antimonate pyrochlore (H1.23Sr0.45SbO3.48) for photocatalytic oxidation of benzene: effective oxygen usage and excellent activity?
  Jing Chen,Yu Shao,Danzhen Li J. Mater. Chem. A, 2017,5, 937-941
• 5. An amorphous Cu–In–S nanoparticle-based precursor ink with improved atom economy for CuInSe2 solar cells with 10.85% efficiency?
  Green Chem., 2017,19, 1268-1277

• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds Organonitrogen compounds
• Solvents and Organic Chemicals Organic Compounds Organic nitrogen compounds Organonitrogen compounds

N-Cyclobutylsulfamoyl Chloride: A Comprehensive Overview

N-Cyclobutylsulfamoyl chloride, with the CAS number 777952-91-7, is a versatile and significant compound in the field of organic chemistry. This compound, also referred to as N-cyclobutylsulfamoyl chloride, is widely recognized for its role in various chemical reactions and applications. Its structure consists of a cyclobutane ring attached to a sulfamoyl chloride group, making it a valuable intermediate in the synthesis of diverse organic molecules.

Recent advancements in synthetic chemistry have highlighted the importance of N-cyclobutylsulfamoyl chloride in constructing complex molecular architectures. Researchers have demonstrated its utility in forming stable amide bonds, which are critical in pharmaceuticals and agrochemicals. The cyclobutane ring introduces unique steric and electronic properties, enabling the compound to participate in a wide range of reactions, including nucleophilic substitutions and condensations.

One of the most notable applications of N-cyclobutylsulfamoyl chloride is its use as an electrophilic reagent in peptide synthesis. The sulfamoyl chloride group acts as an excellent leaving group, facilitating the formation of amide bonds under mild conditions. This property has been exploited in the development of novel drug delivery systems and bioactive molecules. Furthermore, the compound's ability to undergo ring-opening reactions has opened new avenues for the synthesis of cyclic structures with potential applications in materials science.

Recent studies have also explored the use of N-cyclobutylsulfamoyl chloride in catalytic processes. Its ability to act as a catalyst precursor has been leveraged in asymmetric synthesis, where it plays a pivotal role in inducing stereochemical control. This has led to the development of enantioselective methods for synthesizing chiral compounds, which are essential in the pharmaceutical industry.

The synthesis of N-cyclobutylsulfamoyl chloride involves a multi-step process that typically begins with the preparation of cyclobutane derivatives. The introduction of the sulfamoyl group is achieved through nucleophilic substitution reactions, often utilizing thionyl chloride as a chlorinating agent. The optimization of reaction conditions has significantly improved the yield and purity of this compound, making it more accessible for large-scale applications.

In terms of stability and handling, N-cyclobutylsulfamoyl chloride exhibits moderate thermal stability but is highly reactive under basic conditions. Its reactivity makes it suitable for use in both solution-phase and solid-phase synthesis techniques. However, careful handling is required due to its sensitivity to moisture and light.

Looking ahead, ongoing research into N-cyclobutylsulfamoyl chloride is focused on expanding its application scope while improving its synthetic efficiency. Collaborative efforts between academic institutions and industrial research labs are expected to yield innovative uses for this compound in fields such as biotechnology and nanotechnology.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)