• 1. Electrocatalytic synthesis of α,α-gem-dihalide ketones from α-mono-halide ketones and unexpected dimer condensation
  Bei Zhou,Yu-Juan He,Yun-Feng Tao,Lan-Xiang Liu,Min Hu,Zu-Hui Chang,Hong Lei,Jun Lin,Tong Lin,Guan-Ben Du Green Chem. 2022 24 2859
• 2. Direct access to α,α-chlorofluoro arylketones via mild electrophilic heterohalogenation of arylalkynes
  Chuyuan Lin,Lu Chen,Huaping Lin,Yibiao Li,Chengshuo Shen,Min Zhang Org. Chem. Front. 2022 9 2944
• 3. Reactions of 1-aryl-2,2-dihalogenoethanone oximes with tetrasulfur tetranitride (S4N4): a general method for the synthesis of 3-aryl-4-halogeno-1,2,5-thiadiazoles
  Sung Cheol Yoon,Jaeeock Cho,Kyongtae Kim J. Chem. Soc. Perkin Trans. 1 1998 109
• 4. Recent progress on fluorination in aqueous media
  Lian Yang,Tao Dong,Hrishikesh M. Revankar,Cheng-Pan Zhang Green Chem. 2017 19 3951

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

2-Fluoroacetophenone (CAS No. 450-95-3): An Overview of Its Properties, Applications, and Recent Research

2-Fluoroacetophenone (CAS No. 450-95-3) is a versatile organic compound that has garnered significant attention in the fields of organic synthesis, pharmaceuticals, and materials science. This compound, also known as 2-fluorophenyl acetone, is characterized by its unique chemical structure, which includes a fluoro substituent on the phenyl ring and an acetone functional group. The combination of these features makes it a valuable intermediate in the synthesis of various bioactive molecules and pharmaceuticals.

The molecular formula of 2-Fluoroacetophenone is C₈H₇FO, and its molecular weight is 144.14 g/mol. It is a colorless to pale yellow liquid with a characteristic aromatic odor. The compound is soluble in common organic solvents such as ethanol, acetone, and dichloromethane but has limited solubility in water. These physical properties make it suitable for use in a wide range of chemical reactions and processes.

In the realm of organic synthesis, 2-Fluoroacetophenone serves as a key building block for the preparation of more complex molecules. Its reactivity stems from the presence of the ketone group, which can undergo various nucleophilic addition reactions, and the fluoro substituent, which can influence the electronic properties of the molecule. For instance, it can be used in the synthesis of fluorinated heterocycles, which are important intermediates in the development of novel pharmaceuticals and agrochemicals.

Recent research has highlighted the potential of 2-Fluoroacetophenone in the development of new therapeutic agents. A study published in the *Journal of Medicinal Chemistry* reported that derivatives of 2-Fluoroacetophenone exhibit potent antitumor activity against various cancer cell lines. The fluoro substituent was found to enhance the lipophilicity and cell membrane permeability of these compounds, thereby improving their biological activity. This finding opens up new avenues for the design and synthesis of more effective anticancer drugs.

Beyond its applications in pharmaceuticals, 2-Fluoroacetophenone has also found use in materials science. Its unique electronic properties make it a valuable precursor for the synthesis of fluorinated polymers and fluorinated small molecules with potential applications in electronics and coatings. For example, fluorinated polymers derived from 2-Fluoroacetophenone have been shown to exhibit excellent thermal stability and chemical resistance, making them suitable for high-performance applications.

The environmental impact of 2-Fluoroacetophenone is another area of active research. A study published in *Environmental Science & Technology* investigated the biodegradability and ecotoxicity of this compound. The results indicated that while 2-Fluoroacetophenone is not readily biodegradable under standard conditions, it does not exhibit significant ecotoxicity at environmentally relevant concentrations. This information is crucial for assessing its environmental safety and guiding its responsible use.

In conclusion, 2-Fluoroacetophenone (CAS No. 450-95-3) is a multifaceted compound with a wide range of applications in organic synthesis, pharmaceuticals, and materials science. Its unique chemical structure and reactivity make it an invaluable intermediate in the development of novel bioactive molecules and advanced materials. Ongoing research continues to uncover new possibilities for its use, further solidifying its importance in modern chemistry.

• 394-59-2(2,2,2-trifluoro-1-(4-methylphenyl)ethan-1-one)
• 369-41-5(2-fluoro-1-(4-fluorophenyl)ethan-1-one)
• 155628-01-6(1-(3-ethylphenyl)-2,2,2-trifluoroethan-1-one)
• 395-01-7(2,2-Difluoroacetophenone)
• 434-45-7(2,2,2-Trifluoroacetophenone)
• 1736-06-7(3'-Methyl-2,2,2-trifluoroacetophenone)
• 2560-97-6(2-fluoro-1-(3-methylphenyl)ethan-1-one)
• 112260-69-2(2-fluoro-1-(naphthalen-1-yl)ethan-1-one)
• 71365-99-6(2-fluoro-1-(naphthalen-2-yl)ethan-1-one)
• 75524-55-9(Ethanone,1-[1,1'-biphenyl]-4-yl-2-fluoro-)