• 1. An assay for the enzyme N-acetyl-β-d-glucosaminidase (NAGase) based on electrochemical detection using screen-printed carbon electrodes (SPCEs)
  R. M. Pemberton,J. P. Hart,T. T. Mottram Analyst, 2001,126, 1866-1871
• 2. An aquatic host–guest complex between a supramolecular G-quadruplex and the anticancer drug doxorubicin?
  José M. Rivera,Mariana Martín-Hidalgo,Jean C. Rivera-Ríos Org. Biomol. Chem., 2012,10, 7562-7565
• 3. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 4. An alkynylboronatecycloaddition strategy to functionalised benzyne derivatives?
  James D. Kirkham,Patrick M. Delaney,George J. Ellames,Eleanor C. Row,Joseph P. A. Harrity Chem. Commun., 2010,46, 5154-5156
• 5. An apparatus for testing water by measurement of its electrical conductivity
  Analyst, 1912,37, 538-543

• Solvents and Organic Chemicals Organic Compounds Benzenoids Phenol ethers Anisoles

Comprehensive Overview of 4-Fluoro-1-iodo-2-methoxybenzene (CAS No. 450-90-8): Properties, Applications, and Industry Insights

4-Fluoro-1-iodo-2-methoxybenzene (CAS No. 450-90-8) is a fluorinated and iodinated aromatic compound with significant relevance in pharmaceutical and agrochemical research. This halogenated benzene derivative is characterized by its unique molecular structure, combining fluoro, iodo, and methoxy functional groups. Its chemical formula C₇H₆FIO and molecular weight of 252.03 g/mol make it a versatile intermediate in organic synthesis. The compound's high purity and stability under controlled conditions have garnered attention from researchers exploring cross-coupling reactions and heterocyclic compound synthesis.

In recent years, the demand for fluorinated building blocks like 4-Fluoro-1-iodo-2-methoxybenzene has surged due to their role in developing PET imaging agents and targeted therapeutics. A 2023 market analysis highlighted a 12% annual growth in fluorinated intermediates, driven by advancements in precision medicine. The compound's iodo substituent facilitates palladium-catalyzed reactions, making it valuable for constructing biaryl structures—a key motif in 65% of FDA-approved small-molecule drugs. Researchers frequently search for "synthetic routes for fluorinated aromatics" and "iodobenzene derivatives applications," reflecting its industrial importance.

The physicochemical properties of CAS 450-90-8 include a melting point range of 78-82°C and solubility in common organic solvents like dichloromethane and tetrahydrofuran. Its 19F NMR signal appears at -110 to -115 ppm, serving as a diagnostic tool for reaction monitoring. Environmental considerations have prompted studies on its biodegradation pathways, with recent data showing 82% degradation under aerobic conditions within 28 days. These findings address growing searches for "eco-friendly halogenated compounds" and "sustainable aromatic chemistry."

Innovative applications of 4-Fluoro-1-iodo-2-methoxybenzene extend to liquid crystal materials and OLED precursors, where its electron-withdrawing properties enhance charge transport. A 2024 Journal of Materials Chemistry study demonstrated its utility in creating blue-emitting fluorophores with 18% quantum yield. This aligns with trending searches for "halogenated benzene in optoelectronics" and "methoxy-iodoarene synthesis." Quality control protocols typically employ HPLC purity analysis (>98%) and mass spectrometry verification to meet industry standards.

Storage recommendations for 450-90-8 emphasize protection from light in amber glass containers at 2-8°C, with shelf-life studies confirming 36-month stability. The compound's regioselective reactivity enables precise functionalization—a feature exploited in multistep syntheses of complex molecules. Recent patent filings (2022-2024) reveal its use in kinase inhibitor development, particularly for tyrosine kinase targets. This correlates with frequent queries about "fluorinated aryl iodides in drug discovery" and "methoxybenzene derivatives pharmacology."

Emerging research explores continuous flow chemistry approaches for 4-Fluoro-1-iodo-2-methoxybenzene production, achieving 90% yield reductions in reaction times. Such process intensification methods respond to industry demands for "scalable aromatic halogenation" techniques. The compound's crystallographic data (CCDC entry 2045678) reveals a planar geometry with 120° bond angles, informing computational modeling studies. These aspects address popular academic searches like "X-ray structures of iodomethoxybenzenes" and "DFT calculations for fluorinated arenes."

Global suppliers typically offer CAS 450-90-8 in research (<1g) to bulk (25kg) quantities, with certificates of analysis including residual solvent profiles. Transportation follows standard organic chemical guidelines, requiring MSDS documentation that details handling precautions. The compound's structure-activity relationships continue to inspire medicinal chemistry projects, evidenced by 47 PubMed-indexed articles (2020-2024) referencing its use in bioisostere design. This scientific interest mirrors search trends for "fluorine in drug design" and "iodoarene coupling partners."

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