Production Method 1

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Sodium carbonate Solvents: Toluene ;  30 min, rt
1.2 Solvents: Toluene ;  24 h, reflux

Reference

Accessing Heteroannular Benzoxazole and Benzimidazole Scaffolds via Carbodiimides Using Azide-Isocyanide Cross Coupling as Catalyzed by Mesoionic Singlet Palladium Carbene Complexes Derived from Phenothiazine Moiety

Dey, Shreyata ; Ghosh, Prasenjit, ACS Omega, 2023, 8(12), 11039-11064

Production Method 2

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Ammonium chloride Solvents: Glucose ,  Urea ;  rt; 75 - 90 min, 78 - 80 °C

Reference

Sugar-urea-salt eutectic mixture as an efficient green solvent for N-alkylation of heterocyclic secondary amines

Kumar, Koravangala S. Vinay; Swaroop, Toreshettahally R.; Ravi Singh, Krishna; Rangappa, Kanchugarakoppal S.; Sadashiva, Maralinganadoddi P., Chemical Data Collections, 2020, 29,

Production Method 3

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Sodium hydride Solvents: Tetrahydrofuran ;  0 °C; 30 min, rt
1.2 8 h, rt
1.3 Reagents: Water ;  cooled

Reference

Molecular hybridization approach for phenothiazine incorporated 1,2,3-triazole hybrids as promising antimicrobial agents: Design, synthesis, molecular docking and in silico ADME studies

Reddyrajula, Rajkumar; Dalimba, Udayakumar; Madan Kumar, S., European Journal of Medicinal Chemistry, 2019, 168, 263-282

Production Method 4

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Dimethylformamide ;  15 h, rt
1.2 Solvents: Dimethylformamide ;  20 min, rt; 6 h, rt

Reference

Renewable SiO2 as support for NiO catalyst for regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles from azide-alkyne cycloaddition in aqueous media

Boggala, Sasikumar; Perupogu, Vijayanand; Varimalla, Shirisha; Manda, Kalpana; Akula, Venugopal, Molecular Catalysis, 2022, 521,

Production Method 5

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethylformamide ;  4 h, rt

Reference

One-Pot Regioselective Synthesis of Some Novel Isoxazole-Phenothiazine Hybrids and Their Antibacterial Activity

Guguloth, V.; Paidakula, S.; Vadde, R., Russian Journal of General Chemistry, 2020, 90(3), 470-475

Production Method 6

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Potassium hydroxide Solvents: Acetonitrile ;  15 min
1.2 Solvents: Dimethylformamide ;  20 min; 6 h, rt

Reference

Unravel the surface active sites on Cu/MgLaO solid base catalyst by DRIFT spectroscopy and adsorption techniques for the synthesis of triazoles by click reaction

Bilakanti, Vishali; Boosa, Venu; Gutta, Naresh ; Velisoju, Vijay Kumar ; Inkollu, Sreedhar; et al, Molecular Catalysis, 2019, 476,

Production Method 7

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Acetone ;  6 h, reflux

Reference

Molecular diversity of trimethoxyphenyl-1,2,3-triazole hybrids as novel colchicine site tubulin polymerization inhibitors

Fu, Dong-Jun; Li, Ping; Wu, Bo-Wen; Cui, Xin-Xin; Zhao, Cheng-Bin; et al, European Journal of Medicinal Chemistry, 2019, 165, 309-322

Production Method 8

92-84-2

106-96-7

4282-78-4

Reaction Conditions

1.1 Reagents: Potassium tert-butoxide Solvents: Dimethyl sulfoxide ;  30 min, rt
1.2 24 h, rt

Reference

Development of a Focused Library of Triazole-Linked Privileged-Structure-Based Conjugates Leading to the Discovery of Novel Phenotypic Hits against Protozoan Parasitic Infections

Uliassi, Elisa ; Piazzi, Lorna; Belluti, Federica; Mazzanti, Andrea; Kaiser, Marcel; et al, ChemMedChem, 2018, 13(7), 678-683

Production Method 9

106-96-7

606493-61-2

4282-78-4

Reaction Conditions

1.1 Reagents: Sodium carbonate Solvents: Toluene ;  rt → 110 °C; 20 h, 110 °C

Reference

Synthesis of Molecular Dyads and Triads Based Upon N-Annulated Perylene Diimide Monomers and Dimers

Cann, Jonathan R.; Cabanetos, Clement ; Welch, Gregory C., European Journal of Organic Chemistry, 2018, 2018(48), 6933-6943

N-Propargyl Phenothiazine Raw materials

• Phenothiazine
• 3-bromoprop-1-yne
• 10H-Phenothiazine,4a,10a-dihydro-

N-Propargyl Phenothiazine Preparation Products

• N-Propargyl Phenothiazine (4282-78-4)

• 1. An artificial photosynthesis system comprising a covalent triazine framework as an electron relay facilitator for photochemical carbon dioxide reduction?
  Siquan Zhang,Shengyao Wang,Liping Guo,Hao Chen,Bien Tan,Shangbin Jin J. Mater. Chem. C, 2020,8, 192-200
• 2. Aluminium complexes with thio-phosphorus ligands: syntheses and characterisations of [Al2(CyPS3)2(CyPHS2)2] and [Al(S2PPh2)3]?
  Robert P. Davies,Maria A. Giménez,Laura Patel,Andrew J. P. White Dalton Trans., 2008, 5705-5707
• 3. An atomistic mechanism for the degradation of perovskite solar cells by trapped charge?
  Eunhak Lim,Jiyoung Heo,Seong Keun Kim Nanoscale, 2019,11, 11369-11378
• 4. An atom efficient route to N-aryl and N-alkyl pyrrolines by transition metal catalysis?
  Supaporn Sawadjoon,Joseph S. M. Samec Org. Biomol. Chem., 2011,9, 2548-2554
• 5. An integrated process of CO2 capture and in situ hydrogenation to formate using a tunable ethoxyl-functionalized amidine and Rh/bisphosphine system?
  Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002

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