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• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleoside monophosphates
• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleotides Purine ribonucleoside monophosphates

Comprehensive Overview of N6-Methyladenosine-5'-monophosphate Sodium Salt (CAS No. 4229-50-9): Structure, Applications, and Research Insights

N6-Methyladenosine-5'-monophosphate Sodium Salt (CAS 4229-50-9), often abbreviated as m6A-5'-MP Na Salt, is a chemically modified nucleotide derivative that has garnered significant attention in biochemical and pharmaceutical research. This compound features a methyl group at the N6 position of adenosine, combined with a 5'-monophosphate moiety, and is stabilized by sodium ions. Its unique structure makes it a critical tool for studying RNA epigenetics, post-transcriptional modifications, and cellular signaling pathways.

Recent advancements in epitranscriptomics have highlighted the pivotal role of N6-methyladenosine (m6A) in regulating gene expression. As a synthetic analog of endogenous m6A, N6-Methyladenosine-5'-monophosphate Sodium Salt serves as a valuable standard in LC-MS and HPLC analyses, enabling precise quantification of m6A levels in RNA samples. Researchers also utilize it to investigate the enzymatic mechanisms of methyltransferases (e.g., METTL3/METTL14 complex) and demethylases (e.g., FTO, ALKBH5), which are linked to diseases like cancer and metabolic disorders.

The compound’s solubility in aqueous solutions (due to its sodium salt form) enhances its utility in in vitro assays, such as kinase activity studies and nucleotide-protein interaction experiments. Its stability under physiological pH conditions further supports applications in cell culture and drug discovery pipelines. Notably, the rise of mRNA-based therapeutics and vaccine development has spurred demand for high-purity modified nucleotides like this compound to optimize mRNA stability and translational efficiency.

From a commercial perspective, CAS 4229-50-9 is supplied by leading biochemical vendors with ≥95% purity, often verified by NMR and mass spectrometry. Storage recommendations typically include -20°C desiccated conditions to prevent hydrolysis. FAQs from researchers often focus on its compatibility with PCR systems, enzymatic incorporation rates, and alternatives for radiolabeled probes, reflecting its diverse utility.

Emerging trends connect m6A modifications to neurodegenerative diseases (e.g., Alzheimer’s) and immune response modulation, aligning with Google Scholar’s top-searched terms like "m6A and cancer immunotherapy" or "RNA methylation inhibitors." This positions N6-Methyladenosine-5'-monophosphate Sodium Salt as a cornerstone reagent for cutting-edge studies, bridging gaps between basic research and therapeutic innovation.

In summary, the multifaceted applications of CAS 4229-50-9 underscore its importance in modern molecular biology. Its integration into high-throughput screening platforms and diagnostic kit development further cements its relevance. As epitranscriptomics evolves, this compound will remain indispensable for decoding the biological functions of RNA modifications and their clinical implications.

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