• 1. Adenosine/guanosine-3′,5′-bis-phosphates as biocompatible and selective Zn2+-ion chelators. Characterization and comparison with adenosine/guanosine-5′-di-phosphate
  Alon Haim Sayer,Eliav Blum,Dan Thomas Major,Alexandra Vardi-Kilshtain,Bosmat Levi Hevroni,Bilha Fischer Dalton Trans. 2015 44 7305
• 2. Integrated transcriptomics and metabolomics unravel the metabolic pathway variations for barley β-glucan before and after fermentation with L. plantarum DY-1
  Jiayan Zhang,Ping Wang,Cui Tan,Yansheng Zhao,Ying Zhu,Juan Bai,Xiang Xiao Food Funct. 2022 13 4302
• 3. Structure-based design of nucleoside-derived analogues as sulfotransferase inhibitors
  Neil M. Kershaw,Dominic P. Byrne,Hollie Parsons,Neil G. Berry,David G. Fernig,Patrick A. Eyers,Richard Cosstick RSC Adv. 2019 9 32165
• 4. The phosphopantetheinyl transferases: catalysis of a post-translational modification crucial for life
  Joris Beld,Eva C. Sonnenschein,Christopher R. Vickery,Joseph P. Noel,Michael D. Burkart Nat. Prod. Rep. 2014 31 61
• 5. Round, round we go – strategies for enzymatic cofactor regeneration
  Silja Mordhorst,Jennifer N. Andexer Nat. Prod. Rep. 2020 37 1316

• Solvents and Organic Chemicals Organic Compounds Nucleosides, nucleotides, and analogues Purine nucleotides Purine ribonucleotides Purine ribonucleoside bisphosphates

Recent Advances in the Study of 3'-Adenylic acid,5'-(dihydrogen phosphate) (CAS: 1053-73-2)

3'-Adenylic acid,5'-(dihydrogen phosphate), also known as 3'-AMP, is a nucleotide derivative that plays a crucial role in various biochemical processes. With the CAS number 1053-73-2, this compound has garnered significant attention in the field of chemical biology and pharmaceutical research due to its potential applications in drug development, enzyme studies, and metabolic pathways. Recent studies have focused on elucidating its structural properties, biological functions, and therapeutic potential, making it a subject of intense scientific inquiry.

A recent study published in the Journal of Biological Chemistry explored the enzymatic synthesis and characterization of 3'-AMP. The researchers employed advanced spectroscopic techniques, including NMR and mass spectrometry, to confirm the compound's purity and structural integrity. Their findings revealed that 3'-AMP exhibits unique binding affinities to specific enzymes, suggesting its potential as a modulator in enzymatic reactions. This discovery opens new avenues for designing enzyme inhibitors or activators based on 3'-AMP derivatives.

In another groundbreaking study, a team of researchers investigated the role of 3'-AMP in cellular signaling pathways. Using high-throughput screening assays, they identified that 3'-AMP can influence the activity of certain kinases, which are critical regulators of cell proliferation and apoptosis. This finding has significant implications for cancer research, as targeting these kinases with 3'-AMP analogs could lead to the development of novel anticancer therapies. The study also highlighted the compound's stability under physiological conditions, further supporting its potential as a therapeutic agent.

Furthermore, recent advancements in synthetic chemistry have enabled the production of 3'-AMP with high yield and purity. A study in the journal Organic & Biomolecular Chemistry described a novel synthetic route for 3'-AMP using green chemistry principles. The researchers optimized reaction conditions to minimize byproducts and reduce environmental impact, making the process more sustainable. This development is particularly important for large-scale production, ensuring a reliable supply of 3'-AMP for both research and industrial applications.

The pharmacological potential of 3'-AMP has also been explored in the context of neurodegenerative diseases. A preclinical study demonstrated that 3'-AMP could cross the blood-brain barrier and exhibit neuroprotective effects in models of Alzheimer's disease. The compound was shown to reduce oxidative stress and inflammation, two key factors in neurodegeneration. These findings suggest that 3'-AMP or its derivatives could be promising candidates for developing treatments for neurodegenerative disorders.

In summary, recent research on 3'-Adenylic acid,5'-(dihydrogen phosphate) (CAS: 1053-73-2) has unveiled its multifaceted roles in biochemistry and medicine. From its enzymatic interactions to its therapeutic potential, this compound continues to be a focal point of scientific exploration. Future studies are expected to delve deeper into its mechanisms of action and explore its applications in drug design and disease treatment, further solidifying its importance in the field of chemical biology and pharmaceutical sciences.

• 81371-57-5(b-D-xylo-Adenosine, b-D-xylo-adenylyl-(2'®5')-b-D-xylo-adenylyl-(2'®5')- (9CI))
• 2391-46-0(Adenosine, adenylyl-(3'®5')-)
• 102029-96-9(Adenosine, adenylyl-(3'®5')-, monoammonium salt (9CI))
• 126877-05-2(Acetic acid,[4-(2,6-dihydro-2,6-dioxo-7-phenylbenzo[1,2-b:4,5-b']difuran-3-yl)phenoxy]-,2-ethoxyethyl ester)
• 21027-46-3(Adenosine, adenylyl-(3'®5')-, ammonium salt (8CI,9CI))
• 917-44-2(Adenosine, adenylyl-(3'®5')-adenylyl-(3'®5')-)
• 33009-07-3([(2R,3S,4R,5R)-5-(6-Aminopurin-9-yl)-3-[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-4-hydroxyoxolan-2-yl]methoxy-hydroxy-oxophosphanium)
• 72673-13-3(Adenosine,2'-deoxyadenylyl-(3'®5')-2'-deoxyadenylyl-(3'®5')-2'-deoxyadenylyl-(3'®5')-2'-deoxyadenylyl-(3'®5')-2'-deoxyadenylyl-(3'®5')-2'-deoxyadenylyl-(3'®5')-2'-deoxyadenylyl-(3'®5')-2'-deoxy-)
• 52278-63-4(3'-Adenylic acid,monobutyl ester)
• 84-21-9(Adenosine-3'-monophosphate)