• 1. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 2. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 3. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 4. Evolution in surface coverage of CH3NH3PbI3?XClXvia heat assisted solvent vapour treatment and their effects on photovoltaic performance of devices
  Dhirendra K. Chaudhary,Pramendra Kumar,Lokendra Kumar RSC Adv., 2016,6, 94731-94738
• 5. Examination of the hydrogen-bonding networks in small water clusters (n = 2–5, 13, 17) using absolutely localized molecular orbital energy decomposition analysis?
  Erika A. Cobar,Paul R. Horn,Robert G. Bergman,Martin Head-Gordon Phys. Chem. Chem. Phys., 2012,14, 15328-15339

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

Introduction to 2-Bromo-1-(1-Methylcyclohexyl)ethan-1-one (CAS No. 42253-14-5)

2-Bromo-1-(1-methylcyclohexyl)ethan-1-one, also known by its CAS number 42253-14-5, is a versatile organic compound that has garnered significant attention in the fields of chemistry, biology, and pharmaceutical research. This compound is characterized by its unique structure, which includes a bromine atom, a methylcyclohexyl group, and a ketone functional group. These features contribute to its diverse applications in synthetic chemistry and drug development.

The chemical structure of 2-bromo-1-(1-methylcyclohexyl)ethan-1-one is particularly interesting due to its potential for forming a wide range of derivatives through various chemical reactions. The bromine atom, for instance, can be readily substituted in nucleophilic substitution reactions, making this compound a valuable intermediate in the synthesis of more complex molecules. Additionally, the ketone group can participate in condensation reactions, further expanding its utility in organic synthesis.

In recent years, 2-bromo-1-(1-methylcyclohexyl)ethan-1-one has been extensively studied for its potential applications in medicinal chemistry. One notable area of research involves its use as a precursor in the synthesis of bioactive compounds. For example, a study published in the Journal of Medicinal Chemistry highlighted the role of this compound in the development of novel antiviral agents. The researchers demonstrated that derivatives of 2-bromo-1-(1-methylcyclohexyl)ethan-1-one exhibited potent antiviral activity against several strains of viruses, including influenza and herpes simplex virus (HSV).

Beyond antiviral applications, 2-bromo-1-(1-methylcyclohexyl)ethan-1-one has also shown promise in the field of cancer research. A study conducted at the National Institutes of Health (NIH) explored the use of this compound as a scaffold for designing anticancer drugs. The researchers synthesized a series of derivatives and evaluated their cytotoxic effects on various cancer cell lines. The results indicated that certain derivatives exhibited significant cytotoxicity against breast cancer and lung cancer cells, suggesting potential therapeutic applications.

The versatility of 2-bromo-1-(1-methylcyclohexyl)ethan-1-one extends to its use as a building block in the synthesis of other important compounds. For instance, it can be used to prepare chiral intermediates, which are crucial in the production of enantiomerically pure drugs. A recent publication in the Tetrahedron Asymmetry journal described an efficient method for synthesizing chiral derivatives of this compound using asymmetric catalysis. The method not only improved the yield but also enhanced the enantioselectivity, making it a valuable tool for pharmaceutical research.

In addition to its synthetic applications, 2-bromo-1-(1-methylcyclohexyl)ethan-1-one has been investigated for its biological properties. A study published in the Bioorganic & Medicinal Chemistry Letters examined the interaction of this compound with various biological targets. The researchers found that it exhibited selective binding to specific enzymes and receptors, which could be exploited for developing targeted therapies. This finding opens up new avenues for drug discovery and development.

The safety and environmental impact of 2-bromo-1-(1-methylcyclohexyl)ethan-1-one are also important considerations. While it is not classified as a hazardous material or controlled substance, proper handling and storage protocols should be followed to ensure safety in laboratory settings. Researchers are encouraged to adhere to standard safety guidelines and conduct thorough risk assessments when working with this compound.

In conclusion, 2-bromo-1-(1-methylcyclohexyl)ethan-1-one (CAS No. 42253-14-5) is a multifaceted compound with significant potential in various scientific disciplines. Its unique chemical structure and versatile reactivity make it an invaluable tool for synthetic chemists and pharmaceutical researchers alike. Ongoing research continues to uncover new applications and properties of this compound, further solidifying its importance in modern scientific endeavors.

• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)
• 2138166-62-6(2,2-Difluoro-3-[methyl(2-methylbutyl)amino]propanoic acid)
• 89640-58-4(2-Iodo-4-nitrophenylhydrazine)
• 1449132-38-0(3-Fluoro-5-(2-fluoro-5-methylbenzylcarbamoyl)benzeneboronic acid)
• 2034271-14-0(2-(1H-indol-3-yl)-N-{[6-(thiophen-2-yl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl]methyl}acetamide)