• 1. Synthesis and structure revision of symplocin A
  Lu-Ping Shao,Chang-Mei Si,Zhuo-Ya Mao,Wen Zhou,Tadeusz F. Molinski,Bang-Guo Wei,Guo-Qiang Lin Org. Chem. Front. 2017 4 995

• Solvents and Organic Chemicals Organic Compounds Organic acids and derivatives Carboxylic acids and derivatives Amino acids, peptides, and analogues Amino acids and derivatives

Boc-N-Me-Phe-OH (CAS No. 37553-65-4): A Comprehensive Guide to Its Properties and Applications

Boc-N-Me-Phe-OH (CAS No. 37553-65-4) is a protected amino acid derivative widely used in peptide synthesis and pharmaceutical research. This compound, also known as N-tert-Butoxycarbonyl-N-methyl-L-phenylalanine, plays a crucial role in modern organic chemistry due to its unique structural features and versatility. With the increasing demand for peptide-based therapeutics and drug discovery, Boc-N-Me-Phe-OH has gained significant attention from researchers and manufacturers alike.

The molecular structure of Boc-N-Me-Phe-OH combines the aromatic properties of phenylalanine with the protective Boc (tert-butoxycarbonyl) group and N-methylation, making it particularly valuable for creating modified peptides with enhanced stability and bioavailability. Recent trends in peptide drug development have shown growing interest in N-methylated amino acids like this compound, as they often improve metabolic stability and membrane permeability of therapeutic peptides.

In pharmaceutical applications, Boc-N-Me-Phe-OH serves as a key building block for various peptide-based drugs. Its N-methyl modification helps reduce the conformational flexibility of peptide chains, potentially leading to more selective and potent drug candidates. Researchers frequently search for information about "Boc-N-Me-Phe-OH synthesis" and "Boc-N-Me-Phe-OH applications in drug discovery," reflecting the compound's importance in medicinal chemistry.

The synthesis of Boc-N-Me-Phe-OH typically involves the protection of L-phenylalanine with a Boc group, followed by N-methylation. This process requires careful control of reaction conditions to maintain the chiral integrity of the amino acid. Many researchers are particularly interested in "Boc-N-Me-Phe-OH purity standards" and "analytical methods for Boc-N-Me-Phe-OH," as these factors critically impact its performance in downstream applications.

Beyond pharmaceutical uses, Boc-N-Me-Phe-OH finds applications in peptide-based materials science and bioconjugation chemistry. Its aromatic side chain allows for specific interactions in molecular recognition systems, while the Boc protection enables selective deprotection strategies in complex syntheses. Current research trends explore its potential in developing peptide nanomaterials and targeted drug delivery systems.

The market for Boc-protected amino acids like Boc-N-Me-Phe-OH has been growing steadily, driven by expanding peptide therapeutics development and increasing investment in biopharmaceutical research. Quality specifications for this compound typically include requirements for optical purity, chemical purity, and residual solvent content, with analytical techniques like HPLC and NMR being commonly employed for characterization.

Storage and handling of Boc-N-Me-Phe-OH require standard precautions for amino acid derivatives, including protection from moisture and extreme temperatures. Researchers often inquire about "Boc-N-Me-Phe-OH stability" and "storage conditions for Boc-protected amino acids," as these factors significantly affect the compound's shelf life and performance in synthetic applications.

Recent advances in peptide synthesis technologies have further highlighted the importance of Boc-N-Me-Phe-OH and similar building blocks. The development of more efficient solid-phase peptide synthesis methods and automated peptide synthesizers has increased demand for high-quality protected amino acids. This compound's unique combination of N-methylation and aromatic character makes it particularly valuable for creating peptides with specific structural and functional properties.

In conclusion, Boc-N-Me-Phe-OH (CAS No. 37553-65-4) represents an important tool in modern peptide chemistry and drug discovery. Its applications span from pharmaceutical development to materials science, with ongoing research continuing to uncover new potential uses. As the field of peptide therapeutics expands, the demand for specialized building blocks like Boc-N-Me-Phe-OH is expected to grow accordingly.

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