Synthesis and structure revision of symplocin A?
Organic Chemistry Frontiers Pub Date: 2017-02-09 DOI: 10.1039/C7QO00052A
Abstract
Symplocin A, a linear peptide possessing N-terminal N,N-dimethylisoleucine, statine, and valic acid residues, has been synthesized for the first time employing our previously established ‘one-pot intramolecular tandem protocol’. Moreover, the stereochemistry of natural symplocin A was unambiguously revised through the confirmation by 1D NMR, 2D NMR, and HPLC comparisons with an authentic natural product.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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