Production Method 1

700-16-3

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C
2.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

Production Method 2

6485-79-6

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Solvents: Toluene-d8 ;  2 h, rt
2.1 Solvents: Toluene ;  3 d, rt
3.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

Production Method 3

617-86-7

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Solvents: Toluene-d8 ;  -30 °C; 20 h, -15 °C
2.1 Solvents: Toluene-d8 ;  2 h, rt
3.1 Solvents: Toluene ;  3 d, rt
4.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

Production Method 4

6485-79-6

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Solvents: Toluene-d8 ;  -30 °C; 20 h, -15 °C
2.1 Solvents: Toluene-d8 ;  8 h, rt → 50 °C
3.1 Solvents: Toluene ;  3 d, rt
4.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

Production Method 5

2875-18-5

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

Production Method 6

700-16-3

99476-19-4

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Solvents: Toluene ;  3 d, rt
2.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

Production Method 7

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Solvents: Toluene-d8 ;  8 h, rt → 50 °C
2.1 Solvents: Toluene ;  3 d, rt
3.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

Production Method 8

372-47-4

76469-41-5

71902-33-5

3512-18-3

84476-99-3

Reaction Conditions

1.1 Solvents: Toluene-d8 ;  8 h, rt → 50 °C
2.1 Solvents: Toluene ;  3 d, rt
3.1 Reagents: Triethylsilane Catalysts: Di-μ-hydrobis[1,1′-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]dirh… Solvents: Benzene-d6 ;  48 h, rt → 50 °C

Reference

Catalytic hydrodefluorination of fluoroaromatics with silanes as hydrogen source at a binuclear rhodium complex: Characterization of key intermediates

Zamostna, Lada; et al, Journal of Fluorine Chemistry, 2013, 155, 132-142

3-fluoropyridine Raw materials

• Triethylsilane
• 2,3,5,6-Tetrafluoropyridine
• Pentafluoropyridine
• Rhodium, di-μ-hydrobis[1,1'-(1,3-propanediyl)bis[1,1-bis(1-methylethyl)phosphine-κP]]di-
• Triisopropylsilane

3-fluoropyridine Preparation Products

• 2,3,5-Trifluoropyridine (76469-41-5)
• 3,5-Difluoropyridine (71902-33-5)
• 2,3,6-Trifluoropyridine (3512-18-3)
• 3-fluoropyridine (372-47-4)
• 2,5-Difluoropyridine (84476-99-3)

• 1. Studies of the First Electronically Excited State of 3-Fluoropyridine and Its Ionic Structure by Means of REMPI, Two-Photon MATI, One-Photon VUV-MATI Spectroscopy and Franck–Condon Analysis
  Niklas Helle,Tim Raeker,Juergen Grotemeyer Phys. Chem. Chem. Phys. 2022 24 2412
• 2. Surprisingly high, bulk liquid-like mobility of silica-confined ionic liquids
  Ronald G?bel,Peter Hesemann,Jens Weber,Eléonore M?ller,Alwin Friedrich,Sabine Beuermann,Andreas Taubert Phys. Chem. Chem. Phys. 2009 11 3653
• 3. Emission behaviour of a series of bimetallic Cd(ii)–Au(i) coordination polymers
  Akihiko Yamagishi,Takeshi Kawasaki,Kei Hiruma,Hisako Sato,Takafumi Kitazawa Dalton Trans. 2016 45 7823
• 4. Cu catalyzed [4 + 2] cycloaddition for the synthesis of highly substituted 3-fluoropyridines
  Yiwei Fu,Haoyu Shi,Shengshu Lei,Lei Shi,Hao Li Org. Biomol. Chem. 2022 20 3731
• 5. Influence of the coligand in the magnetic properties of a series of copper(ii)–phenylmalonate complexes
  Jorge Pasán,Joaquín Sanchiz,óscar Fabelo,Laura Ca?adillas-Delgado,Mariadel Déniz,Pau Díaz-Gallifa,Carla Martínez-Benito,Francesc Lloret,Miguel Julve,Catalina Ruiz-Pérez CrystEngComm 2014 16 8106

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridines and derivatives
• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives

• 694-52-0(4-fluoropyridine)
• 71902-08-4(3,5-Difluoropyridine)
• 394-67-2(4-Fluoroisoquinoline)
• 396-31-6(3-Fluoroquinoline)
• 71902-15-3(3,5-Difluoropyridine)
• 71902-33-5(3,5-Difluoropyridine)
• 82878-63-5(3,4-Difluoropyridine)
• 163275-65-8(Benzo[f]quinoline,2-fluoro-)
• 84476-99-3(2,5-Difluoropyridine)
• 67815-54-7(3,4,5-Trifluoropyridine)