• 1. meso- and (±)-Bis(phenylsulphinyl)methane. Characterization using nuclear magnetic resonance chemical shift reagents
  Joseph L. Greene,Philip B. Shevlin J. Chem. Soc. D 1971 1092
• 2. meso- and (±)-Bis(phenylsulphinyl)methane. Characterization using nuclear magnetic resonance chemical shift reagents
  Joseph L. Greene,Philip B. Shevlin J. Chem. Soc. D 1971 1092
• 3. Cs2CO3-promoted methylene insertion into disulfide bonds using acetone as a methylene source
  Qian Chen,Guodian Yu,Xiaofeng Wang,Yulin Huang,Yan Yan,Yanping Huo Org. Biomol. Chem. 2018 16 4086
• 4. Novel dithioether–silver(i) coordination architectures: structural diversities by varying the spacers and terminal groups of ligands
  Jian-Rong Li,Xian-He Bu,Jiao Jiao,Wen-Ping Du,Xiu-Hua Xu,Ruo-Hua Zhang Dalton Trans. 2005 464
• 5. Scalable selective electrochemical oxidation of sulfides to sulfoxides
  Zi-Hao Fu,Hao-Dong Tian,Shao-Fei Ni,James S. Wright,Ming Li,Li-Rong Wen,Lin-Bao Zhang Green Chem. 2022 24 4772

• Solvents and Organic Chemicals Organic Compounds Hydrocarbons

Introduction to Bis(phenylthio)methane (CAS No. 3561-67-9)

Bis(phenylthio)methane, with the chemical formula C₁₄H₁₄S₂ and CAS number 3561-67-9, is a significant compound in the field of organic chemistry and has garnered considerable attention due to its unique structural and functional properties. This organosulfur compound, characterized by its two phenylthio (-SPh) groups attached to a central methane carbon, exhibits a range of applications in chemical synthesis, material science, and pharmaceutical research.

The molecular structure of Bis(phenylthio)methane imparts it with distinct chemical reactivity, making it a valuable intermediate in the synthesis of more complex molecules. Its dual sulfur atoms provide opportunities for coordination with various metal ions, which has been explored in catalytic systems and material design. Recent studies have highlighted its potential in the development of novel coordination polymers and metal-organic frameworks (MOFs), where the sulfur-rich environment facilitates stable metal-sulfur interactions essential for structural integrity and functionality.

In the realm of pharmaceutical research, Bis(phenylthio)methane has been investigated for its possible role as a precursor or analog in drug discovery. The phenylthio groups can be modified or incorporated into larger molecular frameworks to enhance binding affinity or metabolic stability. For instance, derivatives of this compound have shown promise in modulating enzyme activity, particularly in cases where sulfur-containing heterocycles are known to interact with biological targets. The versatility of its structure allows chemists to fine-tune properties such as solubility, reactivity, and electronic characteristics, making it a versatile building block.

The synthesis of Bis(phenylthio)methane typically involves the reaction of thiol derivatives with alkyl halides or other suitable electrophiles. Advances in synthetic methodologies have enabled more efficient and scalable production processes, which are crucial for industrial applications. Modern techniques such as transition-metal-catalyzed cross-coupling reactions have further refined the synthesis pathway, reducing byproducts and improving yields. These improvements align with the broader trend toward greener chemistry, where minimizing waste and energy consumption are paramount.

One of the most intriguing aspects of Bis(phenylthio)methane is its potential in materials science. The compound's ability to form stable complexes with transition metals has been leveraged in the development of luminescent materials and sensors. For example, complexes formed with palladium or platinum exhibit unique photophysical properties that can be harnessed for optical applications. Additionally, its role as a ligand in catalytic systems has been explored for applications in organic transformations, including C-H activation and oxidation reactions.

The pharmaceutical industry has also shown interest in Bis(phenylthio)methane due to its structural motif being present in several bioactive natural products. By studying analogs derived from this compound, researchers aim to uncover new therapeutic agents with improved efficacy and reduced side effects. Computational modeling and high-throughput screening have accelerated the discovery process by allowing rapid evaluation of molecular interactions. This interdisciplinary approach combines traditional synthetic chemistry with cutting-edge computational techniques to identify promising candidates for further development.

In conclusion, Bis(phenylthio)methane (CAS No. 3561-67-9) is a multifaceted compound with significant potential across multiple scientific domains. Its unique structural features enable diverse applications ranging from catalysis to pharmaceuticals and materials science. As research continues to uncover new methodologies and applications, this compound is poised to remain a cornerstone in synthetic chemistry and beyond.

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• 100-68-5(Thioanisol)
• 1122-97-0(4-(Methylthio)thiophenol)
• 274-30-6(1,3-Benzodithiole)
• 2314-54-7(Carbonotrithioic acid,diphenyl ester)
• 4832-52-4(Tris(phenylthio)methane)
• 204-14-8(Naphtho[1,8-de]-1,3-dithiin(9CI))
• 56772-75-9(Benzene, [[(methylthio)methyl]thio]-)
• 57198-63-7(1,3-Benzodithiole, 2-(phenylthio)-)
• 699-20-7(Benzene,1,4-bis(methylthio)-)